Understanding The Acute And Cumulative Metabolic Effects Of Prolonged Sitting In Adults
Funder
National Health and Medical Research Council
Funding Amount
$416,597.00
Summary
Sedentary behaviour (sitting time) has been linked to an increased risk of chronic illnesses, including type 2 diabetes and obesity, but recent evidence suggests that light-intensity activity (non-exercise activities of daily living) is associated with reduced risk. These studies will examine whether breaking up sitting time with frequent short periods of activity can overcome the negative effects of prolonged sitting on blood glucose and blood fats in overweight older adults.
Reducing The Mortality Gap For People With Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$1,231,125.00
Summary
People with schizophrenia die >16 years earlier than the general population, mostly due to avoidable diseases such as diabetes and heart disease. This research aims to conduct clinical trials among people with schizophrenia of 1. an existing diabetes medication (metformin) to prevent initial weight gain due to antipsychotic medications and 2. a novel diabetes medication (exenatide) to help people who don’t have adequate weight loss with metformin.
Signaling Pathways To Enhance Potency Of AMPK-targeting Drugs
Funder
National Health and Medical Research Council
Funding Amount
$661,966.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to epidemics of obesity-related metabolic diseases that place enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Our goal is to improve AMPK drug potency by identifying novel processes that sensitize AMPK to drugs.
Optimising Heart Disease Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$4,647,175.00
Summary
As we become older and risk factors such as obesity become more common, our biggest contributor to death and disability, cardiovascular disease (including heart disease), will continue to exert an enormous burden on our health care system and society. We will extend our ground-breaking research on multidisciplinary teams to create new and innovative health care programs to optimise the prevention and management of new heart disease and chronic forms of heart disease.
Discovery Early Career Researcher Award - Grant ID: DE230101466
Funder
Australian Research Council
Funding Amount
$442,723.00
Summary
Violent offenders in the night-time economy: Building the evidence. Alcohol-related violence in entertainment precincts is a significant community safety problem. This project aims to improve knowledge on individuals that are violent in entertainment precincts. It is expected to be the first study globally to use linked data to develop multi-system informed offending trajectories of violent offenders in these settings, examine the impact of patrons bans on offending trajectories, and apply situa ....Violent offenders in the night-time economy: Building the evidence. Alcohol-related violence in entertainment precincts is a significant community safety problem. This project aims to improve knowledge on individuals that are violent in entertainment precincts. It is expected to be the first study globally to use linked data to develop multi-system informed offending trajectories of violent offenders in these settings, examine the impact of patrons bans on offending trajectories, and apply situational action theory to alcohol-related violence. Results are expected to inform a critical knowledge gap and assist in the development of targeted violence preventive responses which reduce harm and make communities safer.Read moreRead less
The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
AusDiab 3: Emerging Risk Factors For And Long-term Incidence Of Cardio-metabolic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,616,397.00
Summary
This study will track 11,000 Australian adults over 12 years to determine how many develop diabetes, obesity, kidney and heart disease. The study will develop ways to best predict those who are going to develop these conditions before they have arisen, and will explore a range of novel risk factors to better understand these conditions.
Discovery Early Career Researcher Award - Grant ID: DE200100359
Funder
Australian Research Council
Funding Amount
$420,960.00
Summary
Preventing crime in public spaces: everyday guardianship & territoriality . Safe public spaces are the cornerstone of liveable cities. Everyday users of public spaces are vital crime prevention guardians because they are frequently present in the absence of formal regulators like police. This project will investigate factors that enhance active guardianship and facilitate crime prevention in public spaces. It aims to generate new knowledge on the extent to which everyday users of public spaces d ....Preventing crime in public spaces: everyday guardianship & territoriality . Safe public spaces are the cornerstone of liveable cities. Everyday users of public spaces are vital crime prevention guardians because they are frequently present in the absence of formal regulators like police. This project will investigate factors that enhance active guardianship and facilitate crime prevention in public spaces. It aims to generate new knowledge on the extent to which everyday users of public spaces develop a sense of territorial control leading to conscious monitoring of public spaces and intervention in social problems. The project aims to inform crime prevention strategies that facilitate active guardianship leading to less crime, reduced fear of crime and enhanced opportunities for pro-social use of public spaces. Read moreRead less
Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less
A Multi-centre RCT To Prevent Secondary Falls In Older People Presenting To The Emergency Department With A Fall
Funder
National Health and Medical Research Council
Funding Amount
$1,534,471.00
Summary
Falls are a leading cause for presentation to Emergency Departments (EDs) by older patients. More than 50% who present to ED with a fall injury have fallen in the previous year. RESPOND is an innovative post-ED discharge program designed to reduce secondary falls in older people. RESPOND extends current falls prevention research and practice by incorporating patient-centred education with behaviour change strategies proven to be effective in the secondary prevention of cardiovascular events.