Innovations in Clinical Education for Physiotherapy Students. Australia has workforce shortages and an ageing population. Physiotherapists are key players in promoting and maintaining good health through their leadership in physical activity and rehabilitation to retain Australians in the workforce and to ensure quality of life for our ageing population. There is a national shortage of physiotherapists. Increasing numbers of physiotherapists are being trained, requiring new models of clinical tr ....Innovations in Clinical Education for Physiotherapy Students. Australia has workforce shortages and an ageing population. Physiotherapists are key players in promoting and maintaining good health through their leadership in physical activity and rehabilitation to retain Australians in the workforce and to ensure quality of life for our ageing population. There is a national shortage of physiotherapists. Increasing numbers of physiotherapists are being trained, requiring new models of clinical training as there is no capacity in conventional training to cope with student numbers. This research will develop and evaluate new models of training incorporating standardised patients (actors) and simulators (mannequins) which increase education capacity. Models are transferable to other health professions.Read moreRead less
Understanding and Managing the Occupational Health Impacts on Investigators of Internet Child Exploitation. Through developing best practice models for managing vicarious trauma in investigators of Internet child exploitation, the project will result in enhanced job satisfaction and less burnout of workers, and reduced health costs for policing organisations. Thus the project addresses a serious occupational health issue and contributes to the goal of promoting and maintaining good health. Furth ....Understanding and Managing the Occupational Health Impacts on Investigators of Internet Child Exploitation. Through developing best practice models for managing vicarious trauma in investigators of Internet child exploitation, the project will result in enhanced job satisfaction and less burnout of workers, and reduced health costs for policing organisations. Thus the project addresses a serious occupational health issue and contributes to the goal of promoting and maintaining good health. Further, by better managing the occupational health of investigators, the project will enhance the capacity of police organisations to deliver on their mission of investigating and preventing Internet child exploitation. This in turn contributes to the reduced consumption of Internet child exploitation and the associated traumatisation of abused victims. Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
Gender equality in Australia: impact on social, economic and health outcomes. This project aims to develop an innovative, Australian-specific multidimensional measure of gender equality. The project’s focus on conceptualising and measuring gender equality in the Australian context will address a significant barrier to the development, implementation and evaluation of targeted gender equality programs and policies. By partnering with government and industry representatives, this project will deve ....Gender equality in Australia: impact on social, economic and health outcomes. This project aims to develop an innovative, Australian-specific multidimensional measure of gender equality. The project’s focus on conceptualising and measuring gender equality in the Australian context will address a significant barrier to the development, implementation and evaluation of targeted gender equality programs and policies. By partnering with government and industry representatives, this project will develop a baseline from which programs and policies can be measured. The project will also establish evidence about the effects of gender equality in relation to economic, social and wellbeing outcomes.Read moreRead less
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less