Characterising Post Stroke Neuroplasticity In Humans – Identifying A Critical Window For Rehabilitation
Funder
National Health and Medical Research Council
Funding Amount
$764,419.00
Summary
Despite major investment in care for stroke patients, almost all have persisting disability. Stroke causes loss of brain cells that cannot be replaced. Some recovery is possible through compensatory mechanisms. In addition, intact cells around the stroke undergo growth that is critical for recovery. Animal studies suggest these changes take place in a “critical window” after stroke. Applying therapies in this window should improve outcomes. We will use novel approaches to define the “critical wi ....Despite major investment in care for stroke patients, almost all have persisting disability. Stroke causes loss of brain cells that cannot be replaced. Some recovery is possible through compensatory mechanisms. In addition, intact cells around the stroke undergo growth that is critical for recovery. Animal studies suggest these changes take place in a “critical window” after stroke. Applying therapies in this window should improve outcomes. We will use novel approaches to define the “critical window” in patients after strokeRead moreRead less
A New Clinical Tool To Assess Fitness-to-drive In Obstructive Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$727,963.00
Summary
Obstructive sleep apnoea (OSA) affects 1 in 4 middle aged adults. OSA results in impaired neurobehavioral function, excessive sleepiness, and more than 2-fold increased motor vehicle crash risk and workplace accidents. However, not all patients are impaired and identifying patients at risk is a daily clinical challenge. This project proposes new and simple measures that can accurately identify patients with OSA who are most vulnerable to alertness failure and motor vehicle accident risk.
Exploring Consumers' Switching and Loyalty Behaviours: Brand Relationship Dynamics. For marketers and academics, understanding the ways that consumers develop relationships with brands is of utmost importance. Brands may inspire loyalty, repeat purchases, continued use, and switching behaviour over time. Yet, continued brand usage and switching behaviours have not yet been studied systematically from a relationship perspective. Fournier's (1998) perspective on brand relationships is used to unde ....Exploring Consumers' Switching and Loyalty Behaviours: Brand Relationship Dynamics. For marketers and academics, understanding the ways that consumers develop relationships with brands is of utmost importance. Brands may inspire loyalty, repeat purchases, continued use, and switching behaviour over time. Yet, continued brand usage and switching behaviours have not yet been studied systematically from a relationship perspective. Fournier's (1998) perspective on brand relationships is used to understand changes in brand behaviours as changes in underlying consumer-brand relationships. This study, using qualitative semi-structured interviews and longitudinal brand diary keeping, will uncover the personal, social, and cultural meanings associated with brand-related changes, significantly advancing our understanding of brand relationship dynamics.
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An investigation into performance characteristics of elite male and female soccer players in training and competition environments. The aim of the project is to identify critical determinants of soccer performance that will improve preparation of Australian teams for international competition. Three studies are proposed. Study One will utilize a decade of physical performance and anthropometric data on male and female soccer players at the Australian Institute of Sport to identify physical perfo ....An investigation into performance characteristics of elite male and female soccer players in training and competition environments. The aim of the project is to identify critical determinants of soccer performance that will improve preparation of Australian teams for international competition. Three studies are proposed. Study One will utilize a decade of physical performance and anthropometric data on male and female soccer players at the Australian Institute of Sport to identify physical performance standards characteristic of elite players. Study Two will comprise match analyses to delineate crucial physical, technical and tactical aspects of individual and team performance. Study three will identify characteristics specific to elite goalkeepers that may be used for monitoring responses to training and competition.Read moreRead less
Sharing values and the co-creation of brands: Towards a new consumer driven branding paradigm. The project proposes a paradigm shift from traditional image building towards a full understanding and integration of consumer values into a deliberate process of co-created brand meanings. Brands thus managed can become iconic and symbolic of consumers' existing subcultures or may even define micro-cultures of consumption of their own (as in the case of Harley Davidson).
Should managers understand t ....Sharing values and the co-creation of brands: Towards a new consumer driven branding paradigm. The project proposes a paradigm shift from traditional image building towards a full understanding and integration of consumer values into a deliberate process of co-created brand meanings. Brands thus managed can become iconic and symbolic of consumers' existing subcultures or may even define micro-cultures of consumption of their own (as in the case of Harley Davidson).
Should managers understand the process by which such co-created brands develop, more Australian brand success stories (eg. Rip Curl, Penfold's Grange) would evolve and be better placed to tap the increasingly diversified sub-cultural landscape that characterises the Australian marketplace and many of our major trading partners.
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New Theory and Algorithms for Nonsmooth Optimisation with Application to Integer Programming. Mathematical optimisation plays a key role in a wide variety of applications in business, industry, engineering and science. For example, airlines cannot fly and radiation treatment for cancer cannot be delivered without solving (a series of) optimisation problems. Some classes of optimisation problem are very well solved, with clear mathematical foundations, efficient algorithms, and reliable software ....New Theory and Algorithms for Nonsmooth Optimisation with Application to Integer Programming. Mathematical optimisation plays a key role in a wide variety of applications in business, industry, engineering and science. For example, airlines cannot fly and radiation treatment for cancer cannot be delivered without solving (a series of) optimisation problems. Some classes of optimisation problem are very well solved, with clear mathematical foundations, efficient algorithms, and reliable software implementations. Both nonsmooth and integer optimisation problems have a good mathematical basis, but there are "gaps"; existing methods cannot always solve real industrial problems. This project will deliver better methods, built on better theory, and so will yield better solutions for important applications.Read moreRead less
Personalised Medicine Markers Of Anti-EGFR Antibody Therapy In Metastatic Colorectal Cancer: Accelerating Clinical Translation With Collaborative Meta-analyses Based On Individual-participant Data
Funder
National Health and Medical Research Council
Funding Amount
$300,953.00
Summary
When selecting cancer therapy we take into account ‘biomarkers’, biological cancer characteristics that predict treatment success. We will work with an international group, the Advanced Colorectal Cancer Database, to analyse individual patient clinical trial data. We intend to validate biomarkers used to select treatment with cetuximab or panitumumab. Cancer genes called KRAS, NRAS, PTEN, PIK3CA, EREG and BRAF will be examined. Our study will provide best evidence for personalised treatment.
How viewers learn about new TV programs: the influence of TV promotions and Word-of-mouth. Television viewing is one of the major pastimes of Australians. Improving the quality of programming and reducing ineffective promotional efforts will enhance the life of most of our population. Keeping and building audiences will improve the long-term viability of free-to-view television model, which allows quality television to be accessible to all. More efficiently marketing local programs improves ....How viewers learn about new TV programs: the influence of TV promotions and Word-of-mouth. Television viewing is one of the major pastimes of Australians. Improving the quality of programming and reducing ineffective promotional efforts will enhance the life of most of our population. Keeping and building audiences will improve the long-term viability of free-to-view television model, which allows quality television to be accessible to all. More efficiently marketing local programs improves return on investment and export potential, as Australian ratings signal to overseas buyers the likely success of the program in their markets. Finally, program promotions provide a valued social purpose as they are used by viewers to choose what to watch. This research seeks to improve the utility of this service.Read moreRead less
Involving children in social research: balancing the risks and benefits. There is a growing consensus that children's involvement in social research is important, but considerable uncertainty remains around children's inclusion in research on 'sensitive' issues, reflecting concerns about how to balance children's protection with their participation. Key to this are deeply embedded assumptions and beliefs about children and childhood, especially concerning notions of capacity, agency, vulnerabili ....Involving children in social research: balancing the risks and benefits. There is a growing consensus that children's involvement in social research is important, but considerable uncertainty remains around children's inclusion in research on 'sensitive' issues, reflecting concerns about how to balance children's protection with their participation. Key to this are deeply embedded assumptions and beliefs about children and childhood, especially concerning notions of capacity, agency, vulnerability, dependency and the like. This project aims to better understand and address the tensions between the protection of children and their participation in research, and to explore how ethics committees, parents, other gatekeepers and children themselves manage and navigate these tensions.Read moreRead less
Effects Of The Fatty Acid, Lauric Acid, On Energy Intake And Gut Motor And Hormonal Function In Health And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$744,645.00
Summary
Obesity is largely due to energy intake exceeding energy expenditure, thus, strategies that reduce energy intake will result in weight loss. We discovered recently that the fatty acid, lauric acid, markedly reduces energy intake. Our studies will determine the effects of lauric acid on energy intake and body weight reduction in obese subjects. The research is a new initiative and explores the potential of lauric acid as a novel, nutrient-based and side-effect free approach to obesity management.