Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
A Genome-wide Association Scan To Identify Genetic Risk Factors For Sight Threatening Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$982,203.00
Summary
Diabetic eye disease is an important complication of diabetes that can lead to blindness. Very little is known about how diabetes causes eye disease, but genetics is known to play a role. We aim to identify genes that contribute to eye disease in diabetes patients. We will compare genes between patients with diabetes with and without severe diabetic eye disease using cutting edge genomic technology. We hope to be able to better predict risk of blindness and to move towards novel treatments.
Industrial Transformation Research Hubs - Grant ID: IH180100002
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Driving Farming Productivity and Disease Prevention. The ARC Research Hub for Driving Farming Productivity and Disease Prevention aims to increase farm production and disease prevention through advancing and transferring new artificial intelligence technologies into industrial deployment. The Hub will combine machine vision, machine learning, software quality control, engineering, biology, and farming industries to develop technologies to build more intelligent systems. Thes ....ARC Research Hub for Driving Farming Productivity and Disease Prevention. The ARC Research Hub for Driving Farming Productivity and Disease Prevention aims to increase farm production and disease prevention through advancing and transferring new artificial intelligence technologies into industrial deployment. The Hub will combine machine vision, machine learning, software quality control, engineering, biology, and farming industries to develop technologies to build more intelligent systems. These dynamic systems will help determine what goal to achieve and the most efficient plan to achieve it. This Hub is expected to contribute to higher farming efficiency, lower production costs and fewer disease risks, giving the Australian industry new business opportunities and an international competitive advantage.Read moreRead less
Masers: high resolution probes of star formation. The largest stars in the Galaxy play a vital role in the formation of
the atoms which make life on Earth possible. The birth of these stars
is shrouded in gas and dust through which only radiowaves penetrate.
In this project we will make observations of interstellar masers from
the hydroxyl and methanol molecules and through mathematical modelling
of molecular excitation and radiative transfer probe the physical,
chemical and evolution ....Masers: high resolution probes of star formation. The largest stars in the Galaxy play a vital role in the formation of
the atoms which make life on Earth possible. The birth of these stars
is shrouded in gas and dust through which only radiowaves penetrate.
In this project we will make observations of interstellar masers from
the hydroxyl and methanol molecules and through mathematical modelling
of molecular excitation and radiative transfer probe the physical,
chemical and evolutionary status of the high-mass stars associated
with the masers.Read moreRead less
Structure and Evolution of High Brightness Temperature Cores of Quasars and Galaxies. Interstellar scintillation, ISS, is a revolutionary new and powerful technique which we will use to study the highest brightness temperature cores of radio quasars with unprecedented angular resolution, and probe the interstellar medium of our Galaxy in a way not previously possible. The combination of scintillation and conventional VLBI allows imaging with light-month to light-year resolution across the known ....Structure and Evolution of High Brightness Temperature Cores of Quasars and Galaxies. Interstellar scintillation, ISS, is a revolutionary new and powerful technique which we will use to study the highest brightness temperature cores of radio quasars with unprecedented angular resolution, and probe the interstellar medium of our Galaxy in a way not previously possible. The combination of scintillation and conventional VLBI allows imaging with light-month to light-year resolution across the known Universe. Scintillation observations are challenging basic synchrotron physics by uncovering quasar cores with temperatures possibly as high as 10^15 K, and lifetimes many times longer than theory. The Ceduna and Hobart telescopes are cornerstones of our scintillation and VLBI proposals.
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Radio Interferometer Studies of Compact Astronomical Sources. The giant black holes in the centres of distant galaxies that are the topic of this study are used to set the reference frame for geodesy on the earth. Remote and exotic as they are, they have real-world applications such as improving the positions available from GPS receivers and measuring continental drift. The signal processing equipment being developed for this new telescope is based on FPGA (field programmable gate array) chips ....Radio Interferometer Studies of Compact Astronomical Sources. The giant black holes in the centres of distant galaxies that are the topic of this study are used to set the reference frame for geodesy on the earth. Remote and exotic as they are, they have real-world applications such as improving the positions available from GPS receivers and measuring continental drift. The signal processing equipment being developed for this new telescope is based on FPGA (field programmable gate array) chips, that promise to revolutionize the data processing industry, from radar to cellular telephones to computer networks. The young scientists who are working on this project will go on to lead the commercial and industrial applications of this new technology.Read moreRead less
Transient Astronomical Sources at Radio Frequencies. Australian radio telescopes are among the finest and most modern anywhere in the world, and they are the only such instruments that can study the Southern Hemisphere sky. The University of Tasmania operates two radio observatories, at Hobart, Tas, and Ceduna, SA, that are used together to detect astronomical pulses arriving simultaneously at the two sites. The techniques of interference suppression, dispersion searching, fast sampling over b ....Transient Astronomical Sources at Radio Frequencies. Australian radio telescopes are among the finest and most modern anywhere in the world, and they are the only such instruments that can study the Southern Hemisphere sky. The University of Tasmania operates two radio observatories, at Hobart, Tas, and Ceduna, SA, that are used together to detect astronomical pulses arriving simultaneously at the two sites. The techniques of interference suppression, dispersion searching, fast sampling over broad bandwidths, and high speed data transmission between Ceduna and Hobart that will be implemented in this project have direct applications in science and the communications industry. The students who will develop this equipment will carry over their expertise to the private sector.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775621
Funder
Australian Research Council
Funding Amount
$494,000.00
Summary
Mileura Widefield Array: A New Low Frequency Telescope. A new radio-quiet site for international radio astronomy is being developed at Mileura in Western Australia. We have constructed a low frequency test array on the site, and established that the site is excellent for radio astronomy. We plan to build a telescope which will observe the early universe, when stars and galaxies where first born. This will be the first telescope capable of this type of measurement of the early universe. In addi ....Mileura Widefield Array: A New Low Frequency Telescope. A new radio-quiet site for international radio astronomy is being developed at Mileura in Western Australia. We have constructed a low frequency test array on the site, and established that the site is excellent for radio astronomy. We plan to build a telescope which will observe the early universe, when stars and galaxies where first born. This will be the first telescope capable of this type of measurement of the early universe. In addition, the telescope will measure the solar wind, and its potential interactions with the earth.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882938
Funder
Australian Research Council
Funding Amount
$1,430,000.00
Summary
MIRA Widefield Array: a new low frequency telescope. A new radio-quiet site for international radio astronomy is being developed at Boolardy in Western Australia. We have constructed a low frequency test array on the site, and established that the site is excellent for radio astronomy. We plan to build a telescope which will observe the early universe, when stars and galaxies where first born. This will be the first telescope capable of this type of measurement of the early universe. In additi ....MIRA Widefield Array: a new low frequency telescope. A new radio-quiet site for international radio astronomy is being developed at Boolardy in Western Australia. We have constructed a low frequency test array on the site, and established that the site is excellent for radio astronomy. We plan to build a telescope which will observe the early universe, when stars and galaxies where first born. This will be the first telescope capable of this type of measurement of the early universe. In addition, the telescope will measure the solar wind, and its potential interactions with the Earth. Read moreRead less