Polymer nanoparticles and their assembled supracolloidal monolithic structures for applications in separation science. This project will generate new polymeric materials that will improve the analysis of complex samples. This will be applied in a wide range of areas of national importance including: pharmaceutical analysis and drug discovery; environmental, clinical and forensic analysis; and energy generation and foods.
Micro-disperse sintered nano-diamonds: a new class of versatile adsorbent for high performance liquid chromatography. Nano-diamond is currently recognised amongst researchers as a highly significant material for the development of new technologies in analytical science, diagnostics and nano-technology. Here, sintered nano-diamond, with its many unique properties, will provide a new generation of stationary phases for use in high performance liquid chromatography.
Biomimetic templating radical polymerisation in nanoreactors. The aim is to develop methodology for synthesis of polymer with hitherto inaccessible control of the microstructure by free radical means, that is the molecular weight distribution and monomer sequences. This will be achieved by combining the two concepts of biomimetic templated radical polymerisation and polymerisation in nanoreactors in the form of submicron-sized micelles or droplets. Scale-up of the methodology will be developed b ....Biomimetic templating radical polymerisation in nanoreactors. The aim is to develop methodology for synthesis of polymer with hitherto inaccessible control of the microstructure by free radical means, that is the molecular weight distribution and monomer sequences. This will be achieved by combining the two concepts of biomimetic templated radical polymerisation and polymerisation in nanoreactors in the form of submicron-sized micelles or droplets. Scale-up of the methodology will be developed based on an environmentally friendly approach whereby miniemulsions are generated using carbon dioxide. Increased ability to control the polymer microstructure will enable advanced design of functional polymers with far-reaching applications in materials science, nanotechnology and nanomedicine. Read moreRead less
Disposable microdevices for fast ion analysis. The design and fabrication of a microdevice for ion chromatography will introduce Australia to the field of miniaturised total analytical systems (µTAS). The availability of infrastructure, technology and experience in the µTAS area will provide the foundation for specialised commercialisation of sophisticated, chip-based analytical instruments. These instruments have important applications in forensic, clinical and environmental chemistry.
Metal complexes for sustainable light-driven synthesis. The aim of this project is to use cheap, abundant transition metal ions and visible light to enable challenging synthetic chemical reactions. The significant problems addressed are that most synthetic reactions using visible light currently require expensive precious metals, and fundamental reaction pathways used by Nature remain inaccessible. Both of these problems limit the scope of synthetic applications. The outcomes will be new knowled ....Metal complexes for sustainable light-driven synthesis. The aim of this project is to use cheap, abundant transition metal ions and visible light to enable challenging synthetic chemical reactions. The significant problems addressed are that most synthetic reactions using visible light currently require expensive precious metals, and fundamental reaction pathways used by Nature remain inaccessible. Both of these problems limit the scope of synthetic applications. The outcomes will be new knowledge and sustainable technologies that can better harness visible light for useful synthetic chemistry applications. The benefits will be more efficient and cost-effective routes to valuable molecules ubiquitous in everyday life.Read moreRead less
The global vaccination revolution: a transnational and comparative perspective. A study of first global immunization campaign will provide a historical dimension to contemporary concerns about pandemic disease, vaccination and bio-terrorism, and generate new insights into the factors determining the success and failure of public health initiatives. The project relates directly to national research priorities in health and safeguarding Australia. It has more specific relevance to Australia. Small ....The global vaccination revolution: a transnational and comparative perspective. A study of first global immunization campaign will provide a historical dimension to contemporary concerns about pandemic disease, vaccination and bio-terrorism, and generate new insights into the factors determining the success and failure of public health initiatives. The project relates directly to national research priorities in health and safeguarding Australia. It has more specific relevance to Australia. Smallpox decimated the Aboriginal population, and quarantine and vaccination have loomed large in Australian history. It builds on Australia's strong scholarship in the fields of virology and immunology and the history of disease and public health.Read moreRead less
The World Arm-to-Arm: The Spread of Smallpox Vaccination and Global Networks of Knowledge and Power, 1799-1805. This project will document the rapid spread of Jenner's vaccine around the world between 1799 and 1805. It will address matters neglected in the existing literature, including the logistics of the global transmission of the vaccine, often literally arm-to-arm; the promotion and reception of vaccination in different social and cultural contexts; and the networks of power and knowledge ....The World Arm-to-Arm: The Spread of Smallpox Vaccination and Global Networks of Knowledge and Power, 1799-1805. This project will document the rapid spread of Jenner's vaccine around the world between 1799 and 1805. It will address matters neglected in the existing literature, including the logistics of the global transmission of the vaccine, often literally arm-to-arm; the promotion and reception of vaccination in different social and cultural contexts; and the networks of power and knowledge that made the Jennerian revolution possible. The project will result in a book and articles, interventions in the literature on globalisation and the adoption of innovation, and a deeper and broader perspective on issues of burning relevance to the world today.Read moreRead less
Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and ....Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and their consequent integration under physiological conditions. This project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community at the cutting edge of science. The project will also deliver intellectual property, which will position Australia at the forefront of bionanotechnology.Read moreRead less
Predicting biodiversity distribution on the Antarctic continental shelf. This project aims to develop an international database of underwater observations to predict the distribution of seafloor biodiversity over the entire Antarctic continental shelf for the present day and to 2100. Antarctic seafloor communities are unique and highly diverse, but their distribution is poorly known because biological data are sparse. These predictions depend on a unique and validated approach to estimate the pr ....Predicting biodiversity distribution on the Antarctic continental shelf. This project aims to develop an international database of underwater observations to predict the distribution of seafloor biodiversity over the entire Antarctic continental shelf for the present day and to 2100. Antarctic seafloor communities are unique and highly diverse, but their distribution is poorly known because biological data are sparse. These predictions depend on a unique and validated approach to estimate the present and future redistribution of surface primary production to the seafloor, and will enable calculating the amount of atmospheric carbon captured and stored at the seafloor. The maps will be at an unprecedented resolution of around 2 kilometres, and be invaluable tools underpinning policy, management and future science.Read moreRead less
Zooplankton and ocean productivity in a changing climate. The scarcity of iron in the Southern Ocean limits biological productivity and carbon uptake. There is currently very little Information on zooplankton iron content, yet available data points to high variability. This variability is leading to poor predictive outcomes for models of Southern Ocean iron and carbon cycling. Our project addresses this knowledge gap by quantifying zooplankton iron content and examining its biogeochemical and ec ....Zooplankton and ocean productivity in a changing climate. The scarcity of iron in the Southern Ocean limits biological productivity and carbon uptake. There is currently very little Information on zooplankton iron content, yet available data points to high variability. This variability is leading to poor predictive outcomes for models of Southern Ocean iron and carbon cycling. Our project addresses this knowledge gap by quantifying zooplankton iron content and examining its biogeochemical and ecological impact on Southern Ocean productivity. Developing an understanding of how iron is cycled through zooplankton will provide significant benefits including improved global models used to quantify current and future patterns of ocean productivity critical for environmental and economic predictions.Read moreRead less