Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989390
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Versatile Scanning X-ray Microscopy Facility at the Australian Synchrotron. The challenges of the modern world means that the Australian community must continue to have access to state of the art research tools. An important component of international synchrotron sources is the very high resolution x-ray microscope. These microscopes are used to image samples of biological, material or environmental significance with extraordinary precision. This project will establish such a microscope at the A ....Versatile Scanning X-ray Microscopy Facility at the Australian Synchrotron. The challenges of the modern world means that the Australian community must continue to have access to state of the art research tools. An important component of international synchrotron sources is the very high resolution x-ray microscope. These microscopes are used to image samples of biological, material or environmental significance with extraordinary precision. This project will establish such a microscope at the Australian Synchrotron in Clayton, and nucleates an extensive nationwide collaboration that is devoted to the development of this and related techniques and their application to problems of national scientific, environmental and technological importance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989648
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Optical test-bed facility for mid infrared components for sensing, imaging and astrophotonics. This test facility will enable Australian researchers to validate optical components and technologies at wavelengths from 2.5 to 20 microns, that are crucial for a wide range of applications including biophotonics, sensing, imaging, defense, and astro-photonics. Technologies related to the Mid IR are
expected to have a significant impact on quality of life and global economy. It will enable Australi ....Optical test-bed facility for mid infrared components for sensing, imaging and astrophotonics. This test facility will enable Australian researchers to validate optical components and technologies at wavelengths from 2.5 to 20 microns, that are crucial for a wide range of applications including biophotonics, sensing, imaging, defense, and astro-photonics. Technologies related to the Mid IR are
expected to have a significant impact on quality of life and global economy. It will enable Australian researchers to achieve a major impact in many areas of Mid IR fundamental and applied science as well as industry sectors such as sensing, biophotonics, defence, health, bio-security and imaging. Read moreRead less
SILICON BASED PHOTONIC CRYSTALS FOR MONITORING BIOMOLECULAR INTERACTIONS. Two great goals of biomolecular science are to monitor biomolecular interactions in real time and with sufficient sensitivity to allow small amounts of biological material to be investigated. The achievement of these goals is limited by the methods of transducing these reactions. The aim of this multidisciplinary proposal is to overcome this limitation by developing photonic devices that exploit the unique properties of na ....SILICON BASED PHOTONIC CRYSTALS FOR MONITORING BIOMOLECULAR INTERACTIONS. Two great goals of biomolecular science are to monitor biomolecular interactions in real time and with sufficient sensitivity to allow small amounts of biological material to be investigated. The achievement of these goals is limited by the methods of transducing these reactions. The aim of this multidisciplinary proposal is to overcome this limitation by developing photonic devices that exploit the unique properties of nanoporous silicon. The hybridisation of DNA will be used as a model biorecognition reaction. Potential applications of these photonic devices are as highly sensitive affinity sensors and as tools for investigating the kinetics of biomolecular interactions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989747
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Ultrafast Dynamics Measurement Facility for the Physical, Biochemical, and Materials Sciences. The term "ultrafast revolution" describes the transformations in science due to ultrafast laser technology. Today, ultrafast lasers are used in surgery, nanomaterial fabrication, biomedical imaging, spectroscopic investigations, and new applications are still emerging. This facility will draw together leading chemists, physicists, and engineers to investigate key ultrafast processes and phenomena in th ....Ultrafast Dynamics Measurement Facility for the Physical, Biochemical, and Materials Sciences. The term "ultrafast revolution" describes the transformations in science due to ultrafast laser technology. Today, ultrafast lasers are used in surgery, nanomaterial fabrication, biomedical imaging, spectroscopic investigations, and new applications are still emerging. This facility will draw together leading chemists, physicists, and engineers to investigate key ultrafast processes and phenomena in the physical, biochemical and material sciences. This is of strategic importance to keep Australia at the global forefront for scientific endeavours, supporting new research and commercial opportunities. This facility will also produce highly trained graduates, who will find employment in industry throughout Australia and globally.Read moreRead less
Development of stable, patterned Self-Assembled Monolayers on carbon for sensors and other nanotechnology applications. Nanotechnology - science at the scale of a billionth of a metre - rests on our ability to manipulate molecules and to build structures that will be part of useful devices. We shall develop new methods to put that chemistry on carbon surfaces - leading to very stable and cheap devices that will have 'real world' applications in environmental monitoring. A 'bottom up' method of f ....Development of stable, patterned Self-Assembled Monolayers on carbon for sensors and other nanotechnology applications. Nanotechnology - science at the scale of a billionth of a metre - rests on our ability to manipulate molecules and to build structures that will be part of useful devices. We shall develop new methods to put that chemistry on carbon surfaces - leading to very stable and cheap devices that will have 'real world' applications in environmental monitoring. A 'bottom up' method of fabrication exploits the ability of similar molecules to line up on a suitable surface, so-called 'self Assembly'. The project is based on sound fundamental science for an applied research outcome and therefore will enhance Australian's standing as a strong scientific country that applies its knowledge at the forefront of technological advancement.Read moreRead less
New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, ....New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, DNA damage and DNA repair using novel DNA biosensors. the novelty of the biosensor technology will be to use the modulation of charge transfer through DNA as a method for determining the structural changes that occur in DNA due to these events occurring.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100096
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
A unique soft matter high-performance scanning probe microscopy (HP-SPM) facility. Soft matter research touches every aspect of our lives as it covers materials from the range of plastics found in cars, television sets and other mass-manufactured products, to new medical materials for tissue engineering and sensors. The proposed facility will enable Australia's leading scientists in this area to understand better how soft matter, including both biological and new advanced soft materials, behave ....A unique soft matter high-performance scanning probe microscopy (HP-SPM) facility. Soft matter research touches every aspect of our lives as it covers materials from the range of plastics found in cars, television sets and other mass-manufactured products, to new medical materials for tissue engineering and sensors. The proposed facility will enable Australia's leading scientists in this area to understand better how soft matter, including both biological and new advanced soft materials, behaves on the nano-scale level. This will put Australian researchers and engineers in a leading position for developing new treatments against cancer and other diseases, as well as harnessing the power of biology for application in areas such as waste treatment and energy production.Read moreRead less
In-field sensors for the detection of illicit drugs. Presumptive field test kits for illicit drugs analysis are typically based on chemical spot tests that produce a coloured product. While relatively easy to apply, such test kits (containing wet chemicals) produce inconclusive colour changes lacking sensitivity, and selectivity requiring a subjective assessment by the examiner. Despite these limitations, these test kits are in widespread use and are routinely used. This study aims to develop s ....In-field sensors for the detection of illicit drugs. Presumptive field test kits for illicit drugs analysis are typically based on chemical spot tests that produce a coloured product. While relatively easy to apply, such test kits (containing wet chemicals) produce inconclusive colour changes lacking sensitivity, and selectivity requiring a subjective assessment by the examiner. Despite these limitations, these test kits are in widespread use and are routinely used. This study aims to develop specific in-field sensors for the detection and identification of illicit drugs. This would significantly enhance the ability of Forensic Services staff to confirm the identity of seized material. Increased specificity would provide valuable early advice to investigators regarding the nature of a seizure and would reduce the likelihood of false positive results. Increased sensitivity would permit the analysis of trace amounts of material from individuals or locations related to an illicit drug consignment.Read moreRead less
Enhanced biocatalysis in organic solvents for pharmaceutical biotransformation. Enzymes such as hydrolases play an important role in biotechnology because of their extreme versatility with respect to substrate specificity and stereoselectivity. The use of lipases as catalysts for optical isomer-specific organic reactions is often limited by unacceptably low enantioselectivities. We will investigate recombinant enzymes cloned from thermophilic lipolytic bacteria for synthetic reactions in orga ....Enhanced biocatalysis in organic solvents for pharmaceutical biotransformation. Enzymes such as hydrolases play an important role in biotechnology because of their extreme versatility with respect to substrate specificity and stereoselectivity. The use of lipases as catalysts for optical isomer-specific organic reactions is often limited by unacceptably low enantioselectivities. We will investigate recombinant enzymes cloned from thermophilic lipolytic bacteria for synthetic reactions in organic solvents, especially chiral resolution of mixtures in the production of pharmaceutical intermediates. Genetic improvement of lipase enantiospecificity and regioselectivity will be achieved using in vitro evolution by recombination and screening. The outcome will be cost-effective production superior biocatalysts with specifically enhanced regiospecific, enantioselective and hydrolytic characteristics.
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Synthesis of nanowires and application as nanosensors for chemical and biological detections. This project is expected to bring significant scientific, economic and social benefits. We will develop a number of techniques for the controlled growth of nanowires and making functional nanoscale systems such as nanosensors. The nanosensors will have important applications in chemistry and biology. Some chemical species can be detected by nanosensors on molecular scale. The nanosensors could be used f ....Synthesis of nanowires and application as nanosensors for chemical and biological detections. This project is expected to bring significant scientific, economic and social benefits. We will develop a number of techniques for the controlled growth of nanowires and making functional nanoscale systems such as nanosensors. The nanosensors will have important applications in chemistry and biology. Some chemical species can be detected by nanosensors on molecular scale. The nanosensors could be used for early diagnostics of cancer disease, detection of viruses, and genomic DNA screening. The nanosensors could also provide a molecular tool for probing living cells without destroying them, through which we can track life within cells in real time.Read moreRead less