Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes o ....Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes of this project are cost-effective and strongly enhanced approaches for biopharmaceuticals recovery, thereby providing significant benefits to accelerate research and development in early stage discovery and manufacture of biologics, therapeutic proteins and vaccines.Read moreRead less
Criminal justice outcomes of injecting drug use and methamphetamine smoking. Injection drug use (IDU) and methamphetamine smoking are associated with the majority of illicit drug-related harms and associated costs in Australia. We will extend our studies of people who inject drugs and people who smoke methamphetamine through record linkage to social and criminal justice datasets. We will characterise the trajectories of participants through social services (e.g. public housing) and law enforceme ....Criminal justice outcomes of injecting drug use and methamphetamine smoking. Injection drug use (IDU) and methamphetamine smoking are associated with the majority of illicit drug-related harms and associated costs in Australia. We will extend our studies of people who inject drugs and people who smoke methamphetamine through record linkage to social and criminal justice datasets. We will characterise the trajectories of participants through social services (e.g. public housing) and law enforcement systems to provide a comprehensive account of social and criminal justice impacts of injection drug use and methamphetamine use in Australia for the first time. Read moreRead less
Relationship of retinal directionality to human retinal anatomy variations. This project aims to improve measurement of retinal directionality, which is the reduction in brightness when a light beam’s entry into the human eye is shifted from the centre to the edge of the pupil. This influences retinal image quality and can be used to measure changes in shape of the peripheral eye. This project will apply advanced technologies in holography, and heads-up displays to explore how retinal directiona ....Relationship of retinal directionality to human retinal anatomy variations. This project aims to improve measurement of retinal directionality, which is the reduction in brightness when a light beam’s entry into the human eye is shifted from the centre to the edge of the pupil. This influences retinal image quality and can be used to measure changes in shape of the peripheral eye. This project will apply advanced technologies in holography, and heads-up displays to explore how retinal directionality changes during accommodation (focusing). The expected outcome is improved understanding of retinal stretching changes during focusing. The benefit is that the project will lead to advancements in retinal imaging.Read moreRead less
Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic ....Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic substances. Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.Read moreRead less
Online violent extremist audiences in Australia and the United Kingdom. This project aims to develop an understanding of the role and influence of the internet on violent extremism. It plans to use mixed methods to investigate the ways in which online messages are received and interpreted and the contexts within which this occurs. It plans to apply an innovative research framework using media theories and concepts to the study of online violent extremism. The project aims to contribute to the de ....Online violent extremist audiences in Australia and the United Kingdom. This project aims to develop an understanding of the role and influence of the internet on violent extremism. It plans to use mixed methods to investigate the ways in which online messages are received and interpreted and the contexts within which this occurs. It plans to apply an innovative research framework using media theories and concepts to the study of online violent extremism. The project aims to contribute to the development of measures to counter violent extremism by addressing assumptions about the relationship between online violent extremist content and violent extremist behaviour; and developing understanding of how violent extremist messaging is received and interpreted.Read moreRead less
Fundamentals of Electrically Conductive Elastomer Composites. This project aims to address the performance instability of stretchable/flexible electronics and devices, by developing mechanically resilient, electrically conductive patterns of nanomaterials to be encased in elastomers. It expects to generate new knowledge in the field of composite processing, to provide fundamentals for composite industry to develop novel strain gauges and conductors. Expected outcomes include a methodology for st ....Fundamentals of Electrically Conductive Elastomer Composites. This project aims to address the performance instability of stretchable/flexible electronics and devices, by developing mechanically resilient, electrically conductive patterns of nanomaterials to be encased in elastomers. It expects to generate new knowledge in the field of composite processing, to provide fundamentals for composite industry to develop novel strain gauges and conductors. Expected outcomes include a methodology for stabilising the cyclic performance of electrically conductive elastomer composites. This project is anticipated to provide significant long-term benefits not only for underwater infrastructure condition monitoring but for remote and personalised health-monitoring.Read moreRead less
Boosting photosynthetic efficiency using a plant nanobionics approach. The project aims to improve light capture and enhance electron transport rates using a plant nanobionics approach. Biocompatible plasmonic low-dimensional transition metal oxides with unique optical and electronics properties will be selected as the bioinspired materials. The investigation will focus on developing oxide compounds as artificial antenna, capturing extended optical wavelengths that are not normally available to ....Boosting photosynthetic efficiency using a plant nanobionics approach. The project aims to improve light capture and enhance electron transport rates using a plant nanobionics approach. Biocompatible plasmonic low-dimensional transition metal oxides with unique optical and electronics properties will be selected as the bioinspired materials. The investigation will focus on developing oxide compounds as artificial antenna, capturing extended optical wavelengths that are not normally available to natural plants. Energetic hot electrons excited from plasmonic materials injected into the plant system will further be explored, achieving unprecedented energy conversion from solar to chemical. The anticipated findings will provide a strong base to develop new plant systems with improved photosynthetic efficiency.Read moreRead less
Veteran suicide: investigating the historical and social dimensions . This project aims to address veteran suicide by conducting an historical and cultural analysis of the ways government, the military and the community have understood, governed, and serviced veterans from 1914-present. This project will generate new knowledge, moving beyond orthodox medical and cultural assessments to explore wider historical, cultural and sociological relations of veteran suicide, including civil military rela ....Veteran suicide: investigating the historical and social dimensions . This project aims to address veteran suicide by conducting an historical and cultural analysis of the ways government, the military and the community have understood, governed, and serviced veterans from 1914-present. This project will generate new knowledge, moving beyond orthodox medical and cultural assessments to explore wider historical, cultural and sociological relations of veteran suicide, including civil military relations, and the influence of the veteran sector and families and community. The project will develop an innovative survey that will form the foundation of a longitudinal social health and wellbeing dataset on veterans, and contribute to policy and service provision to reduce veteran suicide and improve their wellbeing.Read moreRead less
Spiritual Ecologies and Customary Governance in Post-conflict East Timor. This project examines the dynamics of a 'return to custom’ in post-conflict East Timor: a set of practices connecting ancestral house communities with complex ecologies upon which people's livelihoods and well-being depend. Drawing on extensive background experience and detailed comparative studies, the project plans to consider the contribution of custom and its inter-generational legacies to the development of sustainabl ....Spiritual Ecologies and Customary Governance in Post-conflict East Timor. This project examines the dynamics of a 'return to custom’ in post-conflict East Timor: a set of practices connecting ancestral house communities with complex ecologies upon which people's livelihoods and well-being depend. Drawing on extensive background experience and detailed comparative studies, the project plans to consider the contribution of custom and its inter-generational legacies to the development of sustainable social and environmental policies of governance. The project is designed to be both a timely study of social renewal in post-conflict societies, and a contribution to the possibilities of sustainable environmental and resource management in East Timor and the wider region.Read moreRead less
Mechanisms of proxy uptake in biominerals. This project plans to combine nano-analytical and aquaculture methods to develop new models that improve the reliability of paleoclimate reconstructions. The compositions of shells and skeletal materials of marine invertebrates are essential archives for quantifying temperatures and environmental conditions before modern climate records began. However, their reliability relies on understanding their formation. Emerging knowledge from material sciences i ....Mechanisms of proxy uptake in biominerals. This project plans to combine nano-analytical and aquaculture methods to develop new models that improve the reliability of paleoclimate reconstructions. The compositions of shells and skeletal materials of marine invertebrates are essential archives for quantifying temperatures and environmental conditions before modern climate records began. However, their reliability relies on understanding their formation. Emerging knowledge from material sciences indicates that these biocarbonates form via transient precursors rather than direct precipitation from seawater, profoundly affecting their interpretation. This project plans to transfer this new understanding to the earth sciences using nanoscale analytical methods including in vitro geochemical partitioning experiments. This would enable realistic models for geochemical proxy behaviour to be developed, significantly improving paleoclimate interpretations and assessments of ocean acidification effects on marine calcifiers.Read moreRead less