A microscopic and analytical study of extreme thermophile bacteria in simulated environments compared to organic matter in early Earth hydrothermal systems. The study will examine microbial cells and organic residues of cultured thermophilic archaea from simulated extreme environments in terms of temperature, pressure and mineral concentrations. These will be compared, applying observational and geochemical techniques to organic material in geologically earliest ecosystems. A novel approach will ....A microscopic and analytical study of extreme thermophile bacteria in simulated environments compared to organic matter in early Earth hydrothermal systems. The study will examine microbial cells and organic residues of cultured thermophilic archaea from simulated extreme environments in terms of temperature, pressure and mineral concentrations. These will be compared, applying observational and geochemical techniques to organic material in geologically earliest ecosystems. A novel approach will be adopted, of 'backtracking' changes occurring to cultured microbial cells towards their breakdown and disintegration (in contrast to the more common approach of simulating synthesis of organic compounds as a starting point towards structured functioning organisms), and their viability limits. The results of the study will be tested within the currently available theoretical models for the origin of life.Read moreRead less
Weathering on Mars and Australian Analogues: Developing Suitable Chronological Tools and Theoretical Approaches. The research outlined in this proposal will place Australia at the forefront of Mars exploration research. It will lead to the development of new approaches for the analysis of minerals formed by low temperature water-rock interaction and for the interpretation of geochronological results obtained from supergene minerals. The new analytical approaches developed in this project will ha ....Weathering on Mars and Australian Analogues: Developing Suitable Chronological Tools and Theoretical Approaches. The research outlined in this proposal will place Australia at the forefront of Mars exploration research. It will lead to the development of new approaches for the analysis of minerals formed by low temperature water-rock interaction and for the interpretation of geochronological results obtained from supergene minerals. The new analytical approaches developed in this project will have direct application in the study of the paleoclimatological and environmental evolution of Earth and Mars. It will also result in improved understanding of environmental and landscape evolution in Australia, helping to reach the objectives of an Environmentally Sustainable Australia, a national research priority.Read moreRead less
Stable isotopic studies and isotopic dating, Woodleigh Impact Structure, Western Australia: implications for the Late Devonian mass extinction. The 120 km diameter Woodleigh impact structure in the Carnarvon Basin, Western Australia is the third largest Phanerozoic impact structure. K-Ar dating of impact-induced alteration minerals indicates a Late Devonian age for Woodleigh. The precise timing of impact, nature of the impacting body and processes responsible for redistribution of meteoritic com ....Stable isotopic studies and isotopic dating, Woodleigh Impact Structure, Western Australia: implications for the Late Devonian mass extinction. The 120 km diameter Woodleigh impact structure in the Carnarvon Basin, Western Australia is the third largest Phanerozoic impact structure. K-Ar dating of impact-induced alteration minerals indicates a Late Devonian age for Woodleigh. The precise timing of impact, nature of the impacting body and processes responsible for redistribution of meteoritic components will be investigated using a range of analytical methodologies. A search will be made for impact-related sedimentary deposits to see if an extraterrestrial component can be identified and correlated with Woodleigh. The expected outcome is proof of an impact-extinction connection for the Late Devonian mass extinction, one of the largest in Earth history.Read moreRead less
Environmental controls over Fe availability and transport in a forested coastal catchment. Iron is one of a number of elements that are mobilised in catchments, have recognised detrimental impacts to marine settings and are known to be nutrients for toxic cyanobacteria blooms. Knowledge of controls over distribution of Fe is important in catchment management and for sustainable forestry. The total catchment approach will result in an understanding of release and transport of Fe, and other heav ....Environmental controls over Fe availability and transport in a forested coastal catchment. Iron is one of a number of elements that are mobilised in catchments, have recognised detrimental impacts to marine settings and are known to be nutrients for toxic cyanobacteria blooms. Knowledge of controls over distribution of Fe is important in catchment management and for sustainable forestry. The total catchment approach will result in an understanding of release and transport of Fe, and other heavy metals. The outcomes of the study will enable useful comparison to coastal plantations elsewhere in Australia, and overseas. Determination of the relationship to rainfall and hydrological processes will enhance these comparisons plus consideration of climatic change.
Read moreRead less
Computational tools for organic synthesis. This project aims to develop new computer modelling techniques with the ability to rapidly identify efficient synthetic routes to target molecules. The barrier heights, reaction energies, and product selectivities of the individual steps in a multi-step synthesis are key factors determining its overall efficiency, and are traditionally determined empirically. Innovative tools for predicting these properties through computer simulations are the expected ....Computational tools for organic synthesis. This project aims to develop new computer modelling techniques with the ability to rapidly identify efficient synthetic routes to target molecules. The barrier heights, reaction energies, and product selectivities of the individual steps in a multi-step synthesis are key factors determining its overall efficiency, and are traditionally determined empirically. Innovative tools for predicting these properties through computer simulations are the expected outcomes of this project. These tools are anticipated to enable target molecules to be accessed more efficiently, with less expenditure of laboratory resources and a lower environmental impact, thereby contributing to an agile and sustainable chemical industry.Read moreRead less
ARC Centre of Excellence for Core to Crust Fluid Systems. Water is essential for human existence, indeed for life's beginning. The circulation of water between the surface and the deep interior lubricates the internal dynamics that keep Earth geologically alive; it is crucial to most Earth systems, including the evolution of the hydrospher/atmosphere/biosphere, and the development of giant ore deposits. However, the origin, abundance, speciation and movements of fluids inside Earth are largely u ....ARC Centre of Excellence for Core to Crust Fluid Systems. Water is essential for human existence, indeed for life's beginning. The circulation of water between the surface and the deep interior lubricates the internal dynamics that keep Earth geologically alive; it is crucial to most Earth systems, including the evolution of the hydrospher/atmosphere/biosphere, and the development of giant ore deposits. However, the origin, abundance, speciation and movements of fluids inside Earth are largely unknown, and represent key issues in modern geoscience. This CoE will integrate previously disparate fields - geology, tectonics, geochemistry, petrophysics, geophysics and dynamic modelling - to understand the workings of Earth's deep plumbing system.Read moreRead less
The development of copper-free click chemistry to label biomolecules within living cells. Understanding how cells work is central to modern advances in biomedical science, however many cellular processes are invisible to the researcher because of a lack of appropriate tools. This proposal will apply modern chemistry approaches to the design of new chemical tools for visualising biomolecules within living cells and for investigating cell function. This project brings together experts in chemistry ....The development of copper-free click chemistry to label biomolecules within living cells. Understanding how cells work is central to modern advances in biomedical science, however many cellular processes are invisible to the researcher because of a lack of appropriate tools. This proposal will apply modern chemistry approaches to the design of new chemical tools for visualising biomolecules within living cells and for investigating cell function. This project brings together experts in chemistry, stem cells and malaria and has applications for development of much needed new therapeutics. This research will advance biomedical research and generate new discoveries for a competitive advantage for Australian science, with potential economic return for the nation.Read moreRead less
The importance of sediment denitrification in the nitrogen budget of the inshore wet tropics section of the Great Barrier Reef Lagoon. The Great Barrier Reef (GBR) is a World Heritage Area that has significant ecological, economical and social values for the Australian (world) community. Nutrient over-enrichment (eutrophication) associated with runoff from adjacent catchments is a major threat to the GBR. This study will quantify what proportion of the terrestrial nitrogen load delivered to the ....The importance of sediment denitrification in the nitrogen budget of the inshore wet tropics section of the Great Barrier Reef Lagoon. The Great Barrier Reef (GBR) is a World Heritage Area that has significant ecological, economical and social values for the Australian (world) community. Nutrient over-enrichment (eutrophication) associated with runoff from adjacent catchments is a major threat to the GBR. This study will quantify what proportion of the terrestrial nitrogen load delivered to the inshore wet tropics section of the Great Barrier Reef Lagoon is removed through sediment denitrification. Critical information for understanding the process of eutrophication in the GBR Lagoon that will be used by our Industry Partner in the management, rehabilitation and protection of the GBR.Read moreRead less
Tracking mass transport during metamorphism using in situ micro-analysis of minerals. The continental masses we inhabit developed in response to the colossal forces of plate tectonics. Through compression and heating, rocks of the crust can experience fluid loss or melting. Movement of these fluids or magmas can, among other things, impact on the heat budget of Earth, the carbon and water cycles and the formation of ores in the crust. This project will utilize state-of-the-art scientific instrum ....Tracking mass transport during metamorphism using in situ micro-analysis of minerals. The continental masses we inhabit developed in response to the colossal forces of plate tectonics. Through compression and heating, rocks of the crust can experience fluid loss or melting. Movement of these fluids or magmas can, among other things, impact on the heat budget of Earth, the carbon and water cycles and the formation of ores in the crust. This project will utilize state-of-the-art scientific instruments and methods to greatly improve our understanding of these issues, which, in turn, will enhance our knowledge of how the Earth's crust develops. Research training and development will be provided through two PhD projects supported through this project.Read moreRead less
Australian Marine Biodiversity As A Source Of New Drugs To Control Neurodegenerative Disease. With the aging of Australia's population the impact of neurodegenerative diseases such as Alzheimer's and Parkinson's is rapidly on the rise. There is an urgent need to develop new and better drugs to treat the symptoms and underlying cause of these debilitating diseases. Historically, the majority of the world's pharmaceuticals have been drawn from biodiversity (ie plants, microbes and animals). As one ....Australian Marine Biodiversity As A Source Of New Drugs To Control Neurodegenerative Disease. With the aging of Australia's population the impact of neurodegenerative diseases such as Alzheimer's and Parkinson's is rapidly on the rise. There is an urgent need to develop new and better drugs to treat the symptoms and underlying cause of these debilitating diseases. Historically, the majority of the world's pharmaceuticals have been drawn from biodiversity (ie plants, microbes and animals). As one of the few megabiodiverse nations, Australia is ideally positioned to accelerate and focus the search for drugs from nature. This project will explore an exceptionally promising pool of Australian biodiversity, its marine ecosystems, as a source of inspiration for the development of new drugs to treat neurodegenerative diseases. Read moreRead less