Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for cor ....Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for correlating structure and elemental location, the work in this proposal will offer a new paradigm for the study of cellular function and disease. This represents an important advance in the suite of investigative tools available to the biotechology sector and will see a corresponding improvement in our understanding of a wide range of disease states.Read moreRead less
Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. The ....Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. These materials are expected to provide benefits for Australian citizens in the energy and health sectors and contribute to the development of a robust Australian nanotechnology industry. The projects will also provide opportunities for the development of outstanding young scientists and will foster multidisciplinary collaborations.Read moreRead less
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less
Three dimensional polymer structures for bionic applications. The polymer based three dimensional (3D) structures targeted for production in this project will bring unique capabilities to the field of bionics research. A multi-modal 3D scaffold capable of delivering biofactors, supporting cell growth and providing power for stimulation will significantly advance the efforts being made in bionic research. This will have profound effects on the quality of life for those suffering from a range of m ....Three dimensional polymer structures for bionic applications. The polymer based three dimensional (3D) structures targeted for production in this project will bring unique capabilities to the field of bionics research. A multi-modal 3D scaffold capable of delivering biofactors, supporting cell growth and providing power for stimulation will significantly advance the efforts being made in bionic research. This will have profound effects on the quality of life for those suffering from a range of medical conditions, from spinal cord injury through to epilepsy. Here we will demonstrate the capabilities of these novel polymer structures both in-vitro and in-vivo.Read moreRead less
A Changing Climate on the Great Barrier Reef: Present and Future Implications. The Great Barrier Reef is fundamental to the economy of Australia. This national and international icon needs to be preserved in the face of a changing world to ensure on-going sustainability of our marine resources. Ocean acidification, warming water temperatures, increased freshwater disrupt the sensitive symbiotic association of corals the major structure building organisms of reefs. Understanding how these enviro ....A Changing Climate on the Great Barrier Reef: Present and Future Implications. The Great Barrier Reef is fundamental to the economy of Australia. This national and international icon needs to be preserved in the face of a changing world to ensure on-going sustainability of our marine resources. Ocean acidification, warming water temperatures, increased freshwater disrupt the sensitive symbiotic association of corals the major structure building organisms of reefs. Understanding how these environmental stressors result in the decrease in coral health is fundamental to prevent loss of our coral reefs and an important step towards preserving them for future generations.Read moreRead less
Australia Surveys the Galaxies: The Central Role of Environment. The success of Australia's premier astronomical facilities is critical to the development of Australian astronomy in the 21st century. Understanding how galaxies grow and evolve (including our Milky Way) is one of the principal goals of these facilities. This program aims to understand galaxy evolution, by exploring the connection between galaxies and their environments. The Super Science Fellows will gain new insights into the lon ....Australia Surveys the Galaxies: The Central Role of Environment. The success of Australia's premier astronomical facilities is critical to the development of Australian astronomy in the 21st century. Understanding how galaxies grow and evolve (including our Milky Way) is one of the principal goals of these facilities. This program aims to understand galaxy evolution, by exploring the connection between galaxies and their environments. The Super Science Fellows will gain new insights into the longstanding problem of galaxy evolution, and build upon Australia's investment in 21st century astrophysics.Read moreRead less
Neutral Hydrogen in the Universe. This proposal will improve our understanding of the origin and continuing evolution of galaxies like our own Milky Way. It will do so by using powerful new telescopes such as the Australian Square Kilometre Array Pathfinder (ASKAP), being constructed by CSIRO in Western Australia, and new supercomputers to be provided by the new Pawsey High Performance Computing Centre for Square Kilometre Array (SKA) Science in Perth. Combined with expertise in areas of astroph ....Neutral Hydrogen in the Universe. This proposal will improve our understanding of the origin and continuing evolution of galaxies like our own Milky Way. It will do so by using powerful new telescopes such as the Australian Square Kilometre Array Pathfinder (ASKAP), being constructed by CSIRO in Western Australia, and new supercomputers to be provided by the new Pawsey High Performance Computing Centre for Square Kilometre Array (SKA) Science in Perth. Combined with expertise in areas of astrophysics and information technology, the research outlined in this proposal will further advance the case for Australia's bid to host the SKA by establishing a strong community of scientists capable of developing the science and Information and Communication Technologies components for one of the SKA's most important goals.Read moreRead less
New Dimensions in Radio Astronomy: Mining Sparse Datasets with the Australian Square Kilometre Array Pathfinder. Radio astronomy is entering a new era, driven by technological advances that make rapid surveys of the sky possible. As leaders of three major surveys for the Australian Square Kilometre Array Pathfinder (ASKAP) telescope, we will explore three new dimensions of astronomy: searching for transient sources, detecting faint galaxies and investigating cosmic magnetism. The project will pu ....New Dimensions in Radio Astronomy: Mining Sparse Datasets with the Australian Square Kilometre Array Pathfinder. Radio astronomy is entering a new era, driven by technological advances that make rapid surveys of the sky possible. As leaders of three major surveys for the Australian Square Kilometre Array Pathfinder (ASKAP) telescope, we will explore three new dimensions of astronomy: searching for transient sources, detecting faint galaxies and investigating cosmic magnetism. The project will put Australian astronomers at the forefront of international research. In addition to novel scientific results we will produce data resources and software that will be critical for future Square Kilometre Array projects. These will be available online to amateur astronomers and the general public. We will train the next generation of astronomers with the skills required to make breakthrough discoveries.Read moreRead less
Exploiting the discovery of ultra-faint dwarf galaxies in the southern hemisphere sky. The scientific exploitation of newly discovered southern hemisphere ultra-faint Milky Way satellite galaxies will make Australia a leader in this rapidly developing research field. It will be enabled by access to national and international telescope facilities such as the Anglo- Australian Telescope (AAT), Gemini and Magellan, and by access to national computing resources for theoretical simulations. National ....Exploiting the discovery of ultra-faint dwarf galaxies in the southern hemisphere sky. The scientific exploitation of newly discovered southern hemisphere ultra-faint Milky Way satellite galaxies will make Australia a leader in this rapidly developing research field. It will be enabled by access to national and international telescope facilities such as the Anglo- Australian Telescope (AAT), Gemini and Magellan, and by access to national computing resources for theoretical simulations. National benefit will also flow from collaborations between the team and its Super Science Fellows and researchers at overseas institutions. Results from the project will motivate research programs for the coming era of extremely large telescopes and will position the Fellows as potential future leaders in the exploiting the scientific potential of those facilities.Read moreRead less
Geophysical, Galactic, and Extra-Galactic Science with the AuScope and Australian Pathfinder Arrays. Two new radio telescope arrays are under construction in Australia. One is the Australian Square Kilometre Array Pathfinder, near Geraldton. The other is a very long baseline array with antennae near Hobart, Katherine, and Yarragadee. These three antennae work together to observe radio sources far away across the universe. Their observations are used to establish a very accurate coordinate syste ....Geophysical, Galactic, and Extra-Galactic Science with the AuScope and Australian Pathfinder Arrays. Two new radio telescope arrays are under construction in Australia. One is the Australian Square Kilometre Array Pathfinder, near Geraldton. The other is a very long baseline array with antennae near Hobart, Katherine, and Yarragadee. These three antennae work together to observe radio sources far away across the universe. Their observations are used to establish a very accurate coordinate system or reference frame on the earth, to which the global positioning system is aligned. This program will use these new radio telescope arrays to study the Milky Way and other galaxies, and to study continental drift and sea-level rise on the Earth.Read moreRead less