Discovery Early Career Researcher Award - Grant ID: DE140101137
Funder
Australian Research Council
Funding Amount
$389,470.00
Summary
Synthesis, Structure and Utility of Novel P-chiral and C-chiral Organophosphido Metal Complexes . The formation of new molecules requires original methods to achieve their synthesis with greatest efficiency. Organometallic chemistry remains crucial for establishing novel reagents and processes. Driven by advances in organo-multi-metallic chemistry this project will build upon fundamental concepts in main group and transition metal chemistry to establish the area of phosphorous-chiral and carbon- ....Synthesis, Structure and Utility of Novel P-chiral and C-chiral Organophosphido Metal Complexes . The formation of new molecules requires original methods to achieve their synthesis with greatest efficiency. Organometallic chemistry remains crucial for establishing novel reagents and processes. Driven by advances in organo-multi-metallic chemistry this project will build upon fundamental concepts in main group and transition metal chemistry to establish the area of phosphorous-chiral and carbon-chiral organophosphido metal chemistry. By rationally designing and integrating new chiral phosphido ligands into mono- and mixed-metal organometallic complexes, chemists will have access to a suite of new tools for application in asymmetric synthesis and catalysis, all relevant to the fields of structural, sustainable and biological chemistry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100450
Funder
Australian Research Council
Funding Amount
$425,398.00
Summary
Cooperativity by Design: Unlocking Metal-Metal-Ligand Cooperativity. This proposal aims to deliver efficient chemical hydrogen storage by designing new catalysts to facilitate the storage and release of hydrogen fuel. Hydrogen is an important zero-emission fuel for the low carbon energy future. However, to realise the potential of the hydrogen economy, efficient, cost-effective solutions are required for storage and transportation. This project seeks to provide technological and intellectual adv ....Cooperativity by Design: Unlocking Metal-Metal-Ligand Cooperativity. This proposal aims to deliver efficient chemical hydrogen storage by designing new catalysts to facilitate the storage and release of hydrogen fuel. Hydrogen is an important zero-emission fuel for the low carbon energy future. However, to realise the potential of the hydrogen economy, efficient, cost-effective solutions are required for storage and transportation. This project seeks to provide technological and intellectual advances in chemical hydrogen storage methods. These outcomes are expected to provide environmental and economic benefits for Australia’s developing hydrogen economy, both in the energy export market and locally in utilisation of hydrogen as a sustainable fuel.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100381
Funder
Australian Research Council
Funding Amount
$444,000.00
Summary
Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australi ....Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australia and internationally by aiding development of early warning drug monitoring systems, providing the rapid deployment of interventions to reduce drug-related harm in the local community, while facilitating law and government agencies to better direct resources.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100573
Funder
Australian Research Council
Funding Amount
$369,075.00
Summary
A long-term history of mercury in Australasia. This project aims to investigate how natural levels of mercury have changed over time and how human activities have affected mercury atmospheric fluxes and deposition. Using state-of-the-art experimental approaches combining palaeontology and chemistry, the project seeks to build comprehensive knowledge about the flux and sources of mercury in the Southern Hemisphere, to address significant geospatial and temporal gaps in understanding mercury’s env ....A long-term history of mercury in Australasia. This project aims to investigate how natural levels of mercury have changed over time and how human activities have affected mercury atmospheric fluxes and deposition. Using state-of-the-art experimental approaches combining palaeontology and chemistry, the project seeks to build comprehensive knowledge about the flux and sources of mercury in the Southern Hemisphere, to address significant geospatial and temporal gaps in understanding mercury’s environmental impact. Expected outcomes are a more refined understanding of the global biochemical cycle of mercury and its exposure effects on human and wildlife populations. Potential benefits are better-informed international actions designed to reduce environmental and health risks from mercury pollution.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100949
Funder
Australian Research Council
Funding Amount
$425,364.00
Summary
Metal-free strategies for sustainable light-driven synthesis. Innovation in synthetic chemistry drives the discovery of new life-saving drugs, agrochemicals and functional materials. This project aims to use visible light to access underexploited reactive intermediates and harness their unique reactivity in new sustainable synthetic transformations. The new chemical processes are expected to deliver increased economy, efficiency and precision in the synthesis of bioactive molecules that are inac ....Metal-free strategies for sustainable light-driven synthesis. Innovation in synthetic chemistry drives the discovery of new life-saving drugs, agrochemicals and functional materials. This project aims to use visible light to access underexploited reactive intermediates and harness their unique reactivity in new sustainable synthetic transformations. The new chemical processes are expected to deliver increased economy, efficiency and precision in the synthesis of bioactive molecules that are inaccessible or challenging to prepare with existing technologies. The conceptual and practical outcomes of this project are expected to benefit both academia and industry as the use of hazardous and expensive metal catalysts can be avoided, reducing chemical waste and simplifying purification.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100517
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Organocatalysis: A New Horizon for Synthesis of Organic Structures. The current technologies to synthesise organic substances, an important part of human life, often involve the use of excess amounts of reagents or precious and toxic metal catalysts, which incur high production costs and severe environmental impact. This project aims to use organocatalysis, chemical processes catalysed by stable, small, easily accessible, non-metallic organic compounds, to find a solution for these issues. Novel ....Organocatalysis: A New Horizon for Synthesis of Organic Structures. The current technologies to synthesise organic substances, an important part of human life, often involve the use of excess amounts of reagents or precious and toxic metal catalysts, which incur high production costs and severe environmental impact. This project aims to use organocatalysis, chemical processes catalysed by stable, small, easily accessible, non-metallic organic compounds, to find a solution for these issues. Novel organocatalytic methods will be designed and developed in order to promote environmentally friendly, highly efficient and selective chemical procedures for low cost production of laboratory organic substances and application in the industrial synthesis of potential agrochemicals and medicinal agents.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100689
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Applying nature's chemistry to the synthesis of complex bioactive natural products. Organic molecules come in all shapes and sizes, and the synthesis of them is crucial to industries as diverse as pharmaceuticals, electronics, cosmetics and agrochemicals. This project aims to develop new ways of making unusual and potentially useful naturally occurring organic molecules using chemistry that mimics how they are formed in nature.
Discovery Early Career Researcher Award - Grant ID: DE240100664
Funder
Australian Research Council
Funding Amount
$451,847.00
Summary
Pushing the limits of electronic delocalization in organic molecules. This project aims to uncover the factors which control how molecules delocalize electrons in 1, 2, and 3 dimensions. Electronic delocalization is essential for many applications of molecular materials, such as light-harvesting and energy storage, but it remains poorly understood. The expected outcomes of this project include new highly-conductive molecules, transferrable knowledge about aromaticity, and design principles for f ....Pushing the limits of electronic delocalization in organic molecules. This project aims to uncover the factors which control how molecules delocalize electrons in 1, 2, and 3 dimensions. Electronic delocalization is essential for many applications of molecular materials, such as light-harvesting and energy storage, but it remains poorly understood. The expected outcomes of this project include new highly-conductive molecules, transferrable knowledge about aromaticity, and design principles for future organic materials. The expected benefits flow from the foundational nature of this research: pi-conjugated organic molecules have many potential uses, including: sensors (e.g. for environmental monitoring), solar cells, and OLED screens, and this project is expected to improve these technologies and industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102113
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Total synthesis inspired by nature. This project aims to improve and develop the way in which we make organic substances; our medicines, agrochemicals, and designed materials. This will be achieved through biomimetics; which harnesses the power of evolution by mimicking how nature synthesises organic compounds.
Discovery Early Career Researcher Award - Grant ID: DE150101863
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Strained alkenes as chemical probes for cysteine sulfenic acid. This project aims to introduce strained alkenes as probes for cysteine sulfenic acid, a poorly understood biomarker for oxidative stress. This probe will enable rapid detection of cysteine sulfenic acid and meet an urgent need for tools to map cysteine redox signalling. Moreover, since many enzymes feature a cysteine sulfenic acid at their active site, the strained alkene probes will also serve as useful inhibitor probes of these en ....Strained alkenes as chemical probes for cysteine sulfenic acid. This project aims to introduce strained alkenes as probes for cysteine sulfenic acid, a poorly understood biomarker for oxidative stress. This probe will enable rapid detection of cysteine sulfenic acid and meet an urgent need for tools to map cysteine redox signalling. Moreover, since many enzymes feature a cysteine sulfenic acid at their active site, the strained alkene probes will also serve as useful inhibitor probes of these enzymes. Such inhibitor probes will provide critical information for potential therapeutic applications in human conditions associated with oxidative stress such as ageing, cancer, and heart disease.Read moreRead less