Improved Nanoscale and Molecular Models for Nanostructured Carbons, and their Applications in Simulation of Confined Fluids. This project has a multitude of benefits for Australia, a key one of which is the promotion of cross-disciplinary interaction and collaboration to conduct leading edge research in a technologically important area. In addition the project will utilize two PhD students who will be trained in research, and gain a broad range of skills in this multifaceted project involving t ....Improved Nanoscale and Molecular Models for Nanostructured Carbons, and their Applications in Simulation of Confined Fluids. This project has a multitude of benefits for Australia, a key one of which is the promotion of cross-disciplinary interaction and collaboration to conduct leading edge research in a technologically important area. In addition the project will utilize two PhD students who will be trained in research, and gain a broad range of skills in this multifaceted project involving theory, simulation and experiment. The research, grounded in molecular fundamentals, will also lead to the development of advanced tools for adsorption process modelling, useful in process design and scale-up, and contribute to Goal 1 of National Priority Area 3: Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less
The role of bush fires in the formation and fate of dioxin like chemicals in Australia. A global (POPs) treaty signed by more than 100 nations targets the reduction and elimination of dioxins, which are persistent, bioaccumlative and highly toxic to humans. Bushfires have been suggested as the major source of dioxins in Australia. Experimental data indicate bushfires may not represent the actual sources of dioxin. Our aim is to experimentally establish the levels of dioxins formed and re-emi ....The role of bush fires in the formation and fate of dioxin like chemicals in Australia. A global (POPs) treaty signed by more than 100 nations targets the reduction and elimination of dioxins, which are persistent, bioaccumlative and highly toxic to humans. Bushfires have been suggested as the major source of dioxins in Australia. Experimental data indicate bushfires may not represent the actual sources of dioxin. Our aim is to experimentally establish the levels of dioxins formed and re-emitted from bushfires in Australia. The results will assist to make informed decisions that lead to effective action for reducing dioxin contamination in Australia, fulfilling the treaty requirements and protecting the population and environment.
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Generation of peptidomimetic surfaces for biomaterials applications. Biomedical implants are increasingly being used for the treatment of a variety of ailments. This project will significantly contribute to the development of these bioengineered constructs, by introducing an innovative method for tailoring the nature of the surface of these materials with structures that mimic the response of biological surfaces. This technology has the potential to promote favourable interactions of cells with ....Generation of peptidomimetic surfaces for biomaterials applications. Biomedical implants are increasingly being used for the treatment of a variety of ailments. This project will significantly contribute to the development of these bioengineered constructs, by introducing an innovative method for tailoring the nature of the surface of these materials with structures that mimic the response of biological surfaces. This technology has the potential to promote favourable interactions of cells with biomedical implants, and an initial targeted application will be to use these bioengineered constructs in the treatment of preventable blindness and severe visual impairment, afflictions which affect over 180 million individuals worldwide.Read moreRead less
From structures to systems: A hierachical approach to understanding sub-cellular components. This program will dramatically extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Au ....From structures to systems: A hierachical approach to understanding sub-cellular components. This program will dramatically extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Australia at the forefront of developing simulation techniques in biomolecular systems, which are widely used within the chemical and pharmaceutical industries for modelling processes ranging from protein-drug interactions to the phase behaviour of lipids and surfactants. Read moreRead less
Patterned assemblies of molecules on surfaces. Because of their redox and photophysical properties, artificial porphyrin systems have been designed for applications such as light-harvesting antennae, catalysts and sensors. Control of molecular orientation is required in order to construct practical devices, and in this project methods of assembling porphyrins on surfaces in well-defined patterns will be developed. Sophisticated methods will be used to characterise the films produced in these w ....Patterned assemblies of molecules on surfaces. Because of their redox and photophysical properties, artificial porphyrin systems have been designed for applications such as light-harvesting antennae, catalysts and sensors. Control of molecular orientation is required in order to construct practical devices, and in this project methods of assembling porphyrins on surfaces in well-defined patterns will be developed. Sophisticated methods will be used to characterise the films produced in these ways, in order to provide the information necessary to refine procedures and design new molecules suitable for advanced applications. Expected outcomes are new methods and architectures that can ultimately yield devices that act at the molecular level.Read moreRead less
A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project ....A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project will result in a new and cost-effective approach for the identification, tracking and prioritisation of emerging chemical threats and address key national and global health risks. The outcomes include the first spatial and temporal distribution of new emerging chemical threats in Australia.Read moreRead less
Atmospheric fate and processes of semi-volatile organic compounds in tropical climates. The outcomes from this study will contribute fundamental and quantitative information for evaluation of the fate of semi-volatile organic compounds (SOCs) in tropical systems, including Australia's World Heritage ecosystems such as rainforest and the Great Barrier Reef. The study addresses key international knowledge gaps with respect to the influence of climate on SOC atmospheric fate. Australia's geographic ....Atmospheric fate and processes of semi-volatile organic compounds in tropical climates. The outcomes from this study will contribute fundamental and quantitative information for evaluation of the fate of semi-volatile organic compounds (SOCs) in tropical systems, including Australia's World Heritage ecosystems such as rainforest and the Great Barrier Reef. The study addresses key international knowledge gaps with respect to the influence of climate on SOC atmospheric fate. Australia's geographical location within the tropical belt provides an ideal opportunity for leading this field of research and contributes relevant data for its commitment under the Stockholm Convention.Read moreRead less
Establishing the relations between starch nano- and mesostructure and macroscopic physical properties. Starch is the major energy component within human diets, and the most abundant polymer that can be readily extracted from annual crop plants, leading to many actual and potential industrial applications. There are major opportunities to optimise the nutritional value of starches in the human diet, and to enhance the properties of extracted starches as renewable alternatives to petrochemical pol ....Establishing the relations between starch nano- and mesostructure and macroscopic physical properties. Starch is the major energy component within human diets, and the most abundant polymer that can be readily extracted from annual crop plants, leading to many actual and potential industrial applications. There are major opportunities to optimise the nutritional value of starches in the human diet, and to enhance the properties of extracted starches as renewable alternatives to petrochemical polymers. This project will open up our understanding of the structure of starch polymers and show how this relates to important properties such as enzyme digestibility rates, leading to new opportunities for public health and commercial benefits.Read moreRead less
Development of an Adjustable Porphyrin-based Molecular Platform for Nanotechnology Applications. Nanotechnology, the art of molecular control, is often heralded as the next industrial revolution. For this to be realised, the construction of useful devices will require precise control at the molecular level. Our control is realised through a process called self-assembly which means that the once the components of the device are correctly designed, the device will simply be able to put itself tog ....Development of an Adjustable Porphyrin-based Molecular Platform for Nanotechnology Applications. Nanotechnology, the art of molecular control, is often heralded as the next industrial revolution. For this to be realised, the construction of useful devices will require precise control at the molecular level. Our control is realised through a process called self-assembly which means that the once the components of the device are correctly designed, the device will simply be able to put itself together. This research will use nature's light harvesting elements, namely porphyrins, and our ability to precisely control their position with respect to each other to build new, more efficient solar cells.Read moreRead less
Friction-based modelling of the dynamics of nanoconfined fluid mixtures. This project will transform the molecular science of fluid transport in nanoconfined spaces by delivering a tool that will be critical to the development of emerging nanotechnologies. The tool will embed a novel theory in a framework for modelling transport over all scales from nano- to macroscopic. The project will have strong benefits for the advancement of leading-edge fundamental research and in its relevance to a numbe ....Friction-based modelling of the dynamics of nanoconfined fluid mixtures. This project will transform the molecular science of fluid transport in nanoconfined spaces by delivering a tool that will be critical to the development of emerging nanotechnologies. The tool will embed a novel theory in a framework for modelling transport over all scales from nano- to macroscopic. The project will have strong benefits for the advancement of leading-edge fundamental research and in its relevance to a number of novel nanotechnologies. It will be particularly relevant to scientific and industrial developments exploiting new nanomaterials such as AlPO4-25, carbon molecular sieves and carbon nanotubes, as well as in nanofluidics.Read moreRead less