Microfluidic technology to help understand physical damage to brain cells. Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes wi ....Microfluidic technology to help understand physical damage to brain cells. Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes within cells in response to physical damage to networks of brain cells. This is one of the major causes of death and disability in developed nations, and is identified as a risk factor for a range of neurodegenerative diseases including Alzheimer's, Parkinson's and motor neuron disease.Read moreRead less
Enhancing Selectivity and Detection in Miniaturised Analytical Separation Systems. Miniaturisation-compatible stationary phases and detection techniques will be developed for microseparation techniques of capillary electrochromatography and chip-based separation systems, and their analytical applications will be investigated. Replaceable stationary phases (RSP) of chromatographic particles suspended in reversible gels will be created by delivering a liquid RSP to the column followed by in situ ....Enhancing Selectivity and Detection in Miniaturised Analytical Separation Systems. Miniaturisation-compatible stationary phases and detection techniques will be developed for microseparation techniques of capillary electrochromatography and chip-based separation systems, and their analytical applications will be investigated. Replaceable stationary phases (RSP) of chromatographic particles suspended in reversible gels will be created by delivering a liquid RSP to the column followed by in situ immobilisation. This approach offers flexibility in optimising a number of parameters of the column and of its use for sample pre-treatment and preconcentration. Pulsed potentiometric detection will be developed for the abovementioned microseparation techniques, combining the advantages of pulsed amperometric techniques with the more universally responding potentiometric detection.Read moreRead less
The future of shipping: achieving autonomous navigation. This project aims to develop autonomous decision systems and onshore control stations to support the design and operation of unmanned cargo ships. Blending observations, numerical models, virtual reality and machine learning, the project will develop algorithms for unsupervised navigation and embed these in an advanced ship simulator platform capable of responding to environmental conditions and optimising sea freight transport capabilitie ....The future of shipping: achieving autonomous navigation. This project aims to develop autonomous decision systems and onshore control stations to support the design and operation of unmanned cargo ships. Blending observations, numerical models, virtual reality and machine learning, the project will develop algorithms for unsupervised navigation and embed these in an advanced ship simulator platform capable of responding to environmental conditions and optimising sea freight transport capabilities. The expected outcomes will enable the integration of automated controls in ships, including remote-control capabilities. This will support Australia’s transition towards an autonomous shipping industry, delivering greater reliability, efficiency, productivity and safety.Read moreRead less
What controls trace element levels in ore sulfides? A laser-ICPMS perspective. Sub-surface hydrothermal gold and base metal orebodies are surrounded by aprons of elevated metal concentrations, mainly within micro-sulfides, which is one sign mineral explorers use to widen their target. Here we test whether the hostrock contributes metal in the most distant parts of such halos, and if so, what factors control where hostrock metal begins to be detectable in a given system. We will make better model ....What controls trace element levels in ore sulfides? A laser-ICPMS perspective. Sub-surface hydrothermal gold and base metal orebodies are surrounded by aprons of elevated metal concentrations, mainly within micro-sulfides, which is one sign mineral explorers use to widen their target. Here we test whether the hostrock contributes metal in the most distant parts of such halos, and if so, what factors control where hostrock metal begins to be detectable in a given system. We will make better models of how metalliferous waters react with rock, potentially translating into million dollar savings through more efficient exploration. The ultrafine sampling and precision analyses required for this are possible because of an ARC-funded core program at CODES.Read moreRead less
ARC/NHMRC Research Network in Ageing Well. The ARC Research Network on Ageing Well will support interdisciplinary, high quality research in the National Research Priority Goal of Ageing Well, Ageing Productively. It will build scale and focus on Australia's notable research strengths in ageing, promote collaborative research, and extend research capacities. The Network will link outstanding researchers from many disciplines, nurture developing researchers, relate social to health researchers, s ....ARC/NHMRC Research Network in Ageing Well. The ARC Research Network on Ageing Well will support interdisciplinary, high quality research in the National Research Priority Goal of Ageing Well, Ageing Productively. It will build scale and focus on Australia's notable research strengths in ageing, promote collaborative research, and extend research capacities. The Network will link outstanding researchers from many disciplines, nurture developing researchers, relate social to health researchers, strengthen international collaboration, and involve and inform end-point users. It will foster research which responds to the aspirations and needs of older Australians and informs action that can improve experiences of individual and population ageing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100094
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Development of a world-class facility for three dimensional dynamic testing. Development of a world-class facility for three dimensional dynamic testing: This project aims to establish a world-class facility for multi-directional dynamic testing. Currently there are no such facilities in Australia. The ability to recreate dynamic motion in all available degrees-of-freedom opens up enormous fields of research not currently possible in Australia. This includes such areas as vibration testing, mate ....Development of a world-class facility for three dimensional dynamic testing. Development of a world-class facility for three dimensional dynamic testing: This project aims to establish a world-class facility for multi-directional dynamic testing. Currently there are no such facilities in Australia. The ability to recreate dynamic motion in all available degrees-of-freedom opens up enormous fields of research not currently possible in Australia. This includes such areas as vibration testing, materials testing, biomechanics and human factors, blast and earthquake simulations, field robotics, automotive safety research, flight/vehicle simulation, and marine applications including sloshing of liquids and liquefaction of fines. In conjunction with a 3D laser doppler system this facility will be unique in the world for dynamic mechanical testing.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100048
Funder
Australian Research Council
Funding Amount
$466,097.00
Summary
Ammonium-selective membranes to shift water industry into circular economy. The project aims to develop ammonium-selective membranes which are urgently needed in Australian key industries for sustainable ammonia recovery. The project expects to construct the membranes to achieve desirable pore size and surface functionality for fast and selective ammonia transport. The developed membranes should make ammonia recovery from wastewater more effective and sustainable, leading to the healthy waterway ....Ammonium-selective membranes to shift water industry into circular economy. The project aims to develop ammonium-selective membranes which are urgently needed in Australian key industries for sustainable ammonia recovery. The project expects to construct the membranes to achieve desirable pore size and surface functionality for fast and selective ammonia transport. The developed membranes should make ammonia recovery from wastewater more effective and sustainable, leading to the healthy waterway and reduced energy for both ammonia production and removal. Recovered ammonia expects to produce valuable products, supporting agriculture industry and hydrogen economy. The developed membranes should enable water industry's shift into circular economy, providing significant economic and environmental benefits to Australia.Read moreRead less
ARC Centre of Excellence - in Ore Deposits. Australia's minerals industry faces a two-fold challenge - to find new ore deposits and to mine them with maximum efficiency and minimal environmental impact. Those challenges demand a new generation of focused ore deposit research, tailored specifically for the Australian context. The Centre of Excellence in Ore Deposits will provide the foundation of fundamental research required by a successful, efficient and sustainable Australian minerals industry ....ARC Centre of Excellence - in Ore Deposits. Australia's minerals industry faces a two-fold challenge - to find new ore deposits and to mine them with maximum efficiency and minimal environmental impact. Those challenges demand a new generation of focused ore deposit research, tailored specifically for the Australian context. The Centre of Excellence in Ore Deposits will provide the foundation of fundamental research required by a successful, efficient and sustainable Australian minerals industry. The Centre will also play a leading role in the undergraduate and postgraduate training of future geoscientists. The concentration of internationally recognised researchers in the Centre will ensure it maintains its premier position in the international ore deposit research arena.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less