New techniques for modelling, diagnosis and counter measures for cardiac related sleep disordered breathing. Around 50% of congestive heart failure sufferers have some form of sleep disordered breathing. However, little has been done so far to simultaneously monitor, analyse and treat the two conditions. Therefore, this project proposes to develop new technology incorporating mathematical models for heart rate variability, considering the links between sleep disordered breathing and cardiovasc ....New techniques for modelling, diagnosis and counter measures for cardiac related sleep disordered breathing. Around 50% of congestive heart failure sufferers have some form of sleep disordered breathing. However, little has been done so far to simultaneously monitor, analyse and treat the two conditions. Therefore, this project proposes to develop new technology incorporating mathematical models for heart rate variability, considering the links between sleep disordered breathing and cardiovascular disease. This innovation will enable, for the first time, a device capable of accurate and reliable diagnosis of various sleep disorders using only conventional ECG data. Such technology has the potential to produce significant community health benefits, and save several millions of lives worldwide.Read moreRead less
Better emitters, enhanced optics, superior detectors: advancing terahertz science and technology for applications in medicine, agriculture, industry and national security. We will start with a new fundamental study of the interaction of light and matter to explicate the phenomena of the emission, transmission and detection of terahertz electromagnetic radiation. Using our increased understanding of terahertz science, we will then engineer better terahertz sources, optics, and sensors. Better ter ....Better emitters, enhanced optics, superior detectors: advancing terahertz science and technology for applications in medicine, agriculture, industry and national security. We will start with a new fundamental study of the interaction of light and matter to explicate the phenomena of the emission, transmission and detection of terahertz electromagnetic radiation. Using our increased understanding of terahertz science, we will then engineer better terahertz sources, optics, and sensors. Better terahertz technology will open up new applications in medical diagnosis, especially dermatology; industrial productivity, such as quality control; and the detection of contraband, including illicit drugs and explosives. In maintaining good health, transforming industries and safeguarding Australia, advanced terahertz systems will bring the nation health, economic and security benefits.Read moreRead less
Advanced materials and structures for terahertz science and technology. Anthrax, explosives, water, cancer all have characteristic signatures in the terahertz (THz) part of the electromagnetic spectrum. Security, defence, agriculture, medicine are some of the fields where THz science and technology are booming. THz developments offer enhanced national security, prosperity and quality of life. The lack of strong sources of THz radiation is the main factor hampering wider application of THz metho ....Advanced materials and structures for terahertz science and technology. Anthrax, explosives, water, cancer all have characteristic signatures in the terahertz (THz) part of the electromagnetic spectrum. Security, defence, agriculture, medicine are some of the fields where THz science and technology are booming. THz developments offer enhanced national security, prosperity and quality of life. The lack of strong sources of THz radiation is the main factor hampering wider application of THz methods. In this project two university research teams come together to develop more efficient THz emitters. The Darmstadt team will prepare novel materials and structures and the Wollongong team will evaluate them and provide feedback for the next iteration.Read moreRead less
High Efficiency Terahertz Emitters. Between microwaves and visible light lies the terahertz gap - the least explored region of the electromagnetic spectrum. Yet the THz region is precisely where many materials exhibit characteristic signatures that allow them to be detected and identified. For example, anthrax, explosives, water, DNA, plastics, and carcinomas all have distinctive THz signatures. THz methods are revolutionizing medicine, agriculture, industry, and national security. Wider appl ....High Efficiency Terahertz Emitters. Between microwaves and visible light lies the terahertz gap - the least explored region of the electromagnetic spectrum. Yet the THz region is precisely where many materials exhibit characteristic signatures that allow them to be detected and identified. For example, anthrax, explosives, water, DNA, plastics, and carcinomas all have distinctive THz signatures. THz methods are revolutionizing medicine, agriculture, industry, and national security. Wider application is hampered by the lack of powerful sources of THz radiation. We aim to develop more efficient emitters of THz radiation. The national economy, security, and well-being will benefit.Read moreRead less
TeraHertz Cell Cluster Imaging. With this program, Australia will benefit from the interaction between physics, engineering, biology and medicine to develop a new TeraHertz imaging system. The project will identify the factors that contribute to TeraHertz contrast in soft tissue cell cultures, thereby developing a non-invasive imaging system to show contrast between diseased and healthy cells. This is a fundamental step towards a system for diagnosing disease states of skin cells, for example, t ....TeraHertz Cell Cluster Imaging. With this program, Australia will benefit from the interaction between physics, engineering, biology and medicine to develop a new TeraHertz imaging system. The project will identify the factors that contribute to TeraHertz contrast in soft tissue cell cultures, thereby developing a non-invasive imaging system to show contrast between diseased and healthy cells. This is a fundamental step towards a system for diagnosing disease states of skin cells, for example, the early detection of melanoma. Ultimately, Australia will benefit from a new technology, and new diagnostic biomedical techniques, for rapid, non-invasive and reliable skin cancer diagnosis.Read moreRead less
Rare isotopes as tracers of prosthesis debris. The incidence of knee replacement surgery in Australia is 30,000 per year. Limited by wear debris, the lifespan of knee implants is only 10-15 years and can be much shorter. Due to increasing life expectancy, many patients need several surgical procedures. As a multi-disciplinary team of materials-, isotope-tracing- and medical-experts, we aim to understand and monitor wear debris in prostheses. Knee replacement surgery alone imposes a high burden o ....Rare isotopes as tracers of prosthesis debris. The incidence of knee replacement surgery in Australia is 30,000 per year. Limited by wear debris, the lifespan of knee implants is only 10-15 years and can be much shorter. Due to increasing life expectancy, many patients need several surgical procedures. As a multi-disciplinary team of materials-, isotope-tracing- and medical-experts, we aim to understand and monitor wear debris in prostheses. Knee replacement surgery alone imposes a high burden of annually half a billion dollars on the Australian health budget. Controlling and reducing wear debris in prosthesis joints would reduce these costs and improve patients' quality of life.Read moreRead less
Advanced microelectronic transistor structures for novel biosensor technology. This international, interdisciplinary team aims to develop an electronic biosensor technology that will significantly advance biomedical research to combat human disease. This is likely to have a major social impact on the community, improve health outcomes and generate substantial economic potential for the pharmaceutical industry. The principal benefit of this research will be the fabrication of electronic devices b ....Advanced microelectronic transistor structures for novel biosensor technology. This international, interdisciplinary team aims to develop an electronic biosensor technology that will significantly advance biomedical research to combat human disease. This is likely to have a major social impact on the community, improve health outcomes and generate substantial economic potential for the pharmaceutical industry. The principal benefit of this research will be the fabrication of electronic devices based on advanced materials, significantly reducing the time, the biological material used and the complexity of assessing human cell function. In addition to improving health through novel biosensor techniques, this technology is expected to lead to the creation of commercially important intellectual property.Read moreRead less
Manipulation of Biological Particles Using Dielectrophoresis. Dielectrophoretic manipulation and separation of particles has numerous biological and medical applications, e.g. identification and characterisation of individual cells, purification of cell subpopulations from mixture suspensions, etc. This research project aims to develop a high-efficiency and low-cost DEP device for bio-particle manipulation. It will contribute significantly to the advancements in the field of biological Micro-Ele ....Manipulation of Biological Particles Using Dielectrophoresis. Dielectrophoretic manipulation and separation of particles has numerous biological and medical applications, e.g. identification and characterisation of individual cells, purification of cell subpopulations from mixture suspensions, etc. This research project aims to develop a high-efficiency and low-cost DEP device for bio-particle manipulation. It will contribute significantly to the advancements in the field of biological Micro-Electrical-Mechanical-Systems (MEMS) and nanotechnology. Industry will benefit from the expertise on micro/nano-structures and micro/nano-manufacturing achieved by this project.Read moreRead less
Enhanced Mixing Through Particle Motion in Micro-Channels. This study will help place Australia within the forefront of one the key technological endeavours of this century, the development of small-scale microfluidic devices, and, thus, should enable Australian industry to benefit relatively early from these new developments. This new research field seeks to exploit many of the major advances being made in science and engineering. Therefore, the work proposed here clearly addresses the Federal ....Enhanced Mixing Through Particle Motion in Micro-Channels. This study will help place Australia within the forefront of one the key technological endeavours of this century, the development of small-scale microfluidic devices, and, thus, should enable Australian industry to benefit relatively early from these new developments. This new research field seeks to exploit many of the major advances being made in science and engineering. Therefore, the work proposed here clearly addresses the Federal Government's National Research Priority 3, Frontier Technologies for Building and Transforming Australian Industries (priority goals: Breakthrough Science & Frontier Technology). The study will also support the research training of two postgraduate students.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775649
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
An Integrated Multi-Node Microfluidics Facility. The establishment of the proposed facility will enhance Australia's position in microfluidics research, thus contributing to all National Priority areas, particularly the National Priority area 3 through advancement in breakthrough science and frontier technologies. In addition to researchers from participating institutions, the Facility will be made available to other Australian researchers from non-participating organisations at minimum cost. Th ....An Integrated Multi-Node Microfluidics Facility. The establishment of the proposed facility will enhance Australia's position in microfluidics research, thus contributing to all National Priority areas, particularly the National Priority area 3 through advancement in breakthrough science and frontier technologies. In addition to researchers from participating institutions, the Facility will be made available to other Australian researchers from non-participating organisations at minimum cost. The socio-economic potentials of the research carried out using the proposed facility are significant and include: R&D development, small scale high technology manufacture, exports, and improved methods of biochemical processing and medical diagnostics.Read moreRead less