A rational approach to a high-resolution structure of the multidrug transporter EmrE. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. Multidrug transporters are membrane proteins responsible for antibiotic resistance in humans. A high-resolution structure of a multidrug resistance protein, together with comprehensive biochemical characterization, w ....A rational approach to a high-resolution structure of the multidrug transporter EmrE. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. Multidrug transporters are membrane proteins responsible for antibiotic resistance in humans. A high-resolution structure of a multidrug resistance protein, together with comprehensive biochemical characterization, would enable a detailed understanding of how these protein functions. Potentially it could also aid in the development of specific inhibitors that would prevent EmrE (and perhaps other similar proteins) from carry out its harmful mission. Read moreRead less
Precise frequency generation for testing fundamental physics and developing new devices. Precision microwave oscillators developed in Australia and France have applications in telecommunications, advanced radar, optical to microwave links, frequency and time standards, tests of fundamental physics etc. This project will aid in the transfer of new knowledge between France and Australia and strengthen Australian 'know how' and expertise, essential for the timely development of technology, which in ....Precise frequency generation for testing fundamental physics and developing new devices. Precision microwave oscillators developed in Australia and France have applications in telecommunications, advanced radar, optical to microwave links, frequency and time standards, tests of fundamental physics etc. This project will aid in the transfer of new knowledge between France and Australia and strengthen Australian 'know how' and expertise, essential for the timely development of technology, which includes devices for the European Space Agency's Atomic Clock Ensemble in Space mission, which is due for launch in 2010. This project highlights the importance of Australian Science in a high profile international mission.Read moreRead less
Biodegradable polymeric microparticles for targeted delivery. The use of microparticles with tuneable physicochemical properties and loading characteristics is of interest in the fields of biomaterials, drug delivery and imaging. Such engineered particles are likely to address problems associated with conventional drugs and drug carriers, including poor disease site selectivity, polymer toxicity, non-biodegradability and free diffusion of drugs throughout the body. These microparticles may provi ....Biodegradable polymeric microparticles for targeted delivery. The use of microparticles with tuneable physicochemical properties and loading characteristics is of interest in the fields of biomaterials, drug delivery and imaging. Such engineered particles are likely to address problems associated with conventional drugs and drug carriers, including poor disease site selectivity, polymer toxicity, non-biodegradability and free diffusion of drugs throughout the body. These microparticles may provide direct advantages to society, including minimally invasive and fast in-vivo diagnostics, localised delivery of drugs and therapeutic agents with increased bioavailability, patient acceptability and reduced healthcare costs.Read moreRead less
Materials World Network: Nanostructured Polymer Templating of Liquid Crystals. Liquid crystals have a range of technological applications, with the most successful being displays used in computers, watches and calculators. These applications are dependent on controlling the interfaces of liquid crystals. This project will combine the areas of liquid crystals and polymer adsorption for the preparation of a new class of intelligent nanomaterials with well-defined properties. These engineered mater ....Materials World Network: Nanostructured Polymer Templating of Liquid Crystals. Liquid crystals have a range of technological applications, with the most successful being displays used in computers, watches and calculators. These applications are dependent on controlling the interfaces of liquid crystals. This project will combine the areas of liquid crystals and polymer adsorption for the preparation of a new class of intelligent nanomaterials with well-defined properties. These engineered materials are of interest in industrial applications, including the development of chemical and biological sensors and drug delivery vehicles. This program also strengthens the ties between two world-class nanotechnology groups, capturing new opportunities in nanostructured materials.Read moreRead less
Increasing the Efficiency of Biomolecular Simulations. This program will extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Australia at the forefront of developing simulation t ....Increasing the Efficiency of Biomolecular Simulations. This program will extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Australia at the forefront of developing simulation techniques in biomolecular systems, which are widely used within the chemical and pharmaceutical industries. It will also provide opportunities for the training and development of young Australian researchers with top European laboratories. Read moreRead less
Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Austral ....Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Australian scientists with their first access to x-ray microscopy at its optimum wavelength; and secondly it will provide a superb testbed for x-ray microscopy to be enhanced using unique methods being developed in Australia.Read moreRead less
Palaeoclimate reconstruction in northwestern China. Records of climatic change between semi-arid regions of the two large continents, China and Australia, provide invaluable data on the manner in which the globe has responded to past environmental changes. Such reconstructions impose constraints on possible patterns of future change.
The visit by an established researcher in Prof. Sun Jiamin will provide new data (including new dates) on the evolution of lakes and dunefields in China, and on ....Palaeoclimate reconstruction in northwestern China. Records of climatic change between semi-arid regions of the two large continents, China and Australia, provide invaluable data on the manner in which the globe has responded to past environmental changes. Such reconstructions impose constraints on possible patterns of future change.
The visit by an established researcher in Prof. Sun Jiamin will provide new data (including new dates) on the evolution of lakes and dunefields in China, and on the climatic conditions which controlled them. The visit builds on and extends the established links between the Chinese Academy of Sciences and staff in the Melbourne University, School of Earth Sciences.
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Studying cell mechanics with a biophotonics-based tool. This study will help to promote and maintain good health. There is a connection between diseases such as arthritis and osteoporosis and cell mechanics. Our study will provide insight into cell mechanics, thereby helping to understand the pathophysiology of these diseases. The study is relevant to tissue engineering. There is ongoing research on mechanical conditioning of tissue substitutes. Understanding cell mechanics will help to optimise ....Studying cell mechanics with a biophotonics-based tool. This study will help to promote and maintain good health. There is a connection between diseases such as arthritis and osteoporosis and cell mechanics. Our study will provide insight into cell mechanics, thereby helping to understand the pathophysiology of these diseases. The study is relevant to tissue engineering. There is ongoing research on mechanical conditioning of tissue substitutes. Understanding cell mechanics will help to optimise conditioning protocols, thereby improving the properties of engineered tissue.
During this study we will develop optical tools that have applications in the life sciences, in the development of advanced materials and in nanotechnology. Our project will promote Australian research in these fields.Read moreRead less
Design and Creation of Nanomechanical Architectures from Folding of Ultrathin Bi-layer Films. The project will achieve progress in designing, modelling, analyzing, and characterization of nanomechanical architectures that will have broad application in Australian science and industry. If successful, our research will revolutionize nanofabrication technology and nano-design methods. The project will lead to a scientific understanding of atomic interaction and stress field effect in the formation ....Design and Creation of Nanomechanical Architectures from Folding of Ultrathin Bi-layer Films. The project will achieve progress in designing, modelling, analyzing, and characterization of nanomechanical architectures that will have broad application in Australian science and industry. If successful, our research will revolutionize nanofabrication technology and nano-design methods. The project will lead to a scientific understanding of atomic interaction and stress field effect in the formation of nanosystems. The result of this research will significantly lower fabrication costs and enhance the potential of nanomaterials in various areas such as electronics and bioelectronics, telecommunication, medical instrumentations, and pharmaceutical design. Read moreRead less
Measuring the linewidth enhancement factor and optical feedback level factor of semiconductor lasers based on optical feedback self-mixing interferometry. This project aims to develop a high performance solution for the challenging problem of measuring the linewidth enhancement factor (LEF) of semiconductor lasers (SLs) and the optical feedback level factor, C, for the optical feedback self-mixing (OFSM) systems. Specific outcomes of the research include (1) a new model for an optical feedback ....Measuring the linewidth enhancement factor and optical feedback level factor of semiconductor lasers based on optical feedback self-mixing interferometry. This project aims to develop a high performance solution for the challenging problem of measuring the linewidth enhancement factor (LEF) of semiconductor lasers (SLs) and the optical feedback level factor, C, for the optical feedback self-mixing (OFSM) systems. Specific outcomes of the research include (1) a new model for an optical feedback self-mixing effect, (2) a new approach for measuring LEF and C based on the proposed model, (3) signal processing algorithms for improving the performance of the proposed approach, and (4) an OFSM system prototype based on the new model and algorithms.Read moreRead less