Reduction Of Oxygen After Cardiac Arrest: The EXACT Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,891,021.00
Summary
We aim to conduct a Phase 3 multi-centre, randomised, controlled trial to determine whether reducing oxygen administration to target a normal level as soon as possible following successful resuscitation from out-of-hospital cardiac arrest, compared to current practice of maintaining 100% oxygen, improves patient survival at hospital discharge.
Next-generation ocean current forecasting to improve maritime safety . This project aims to measure upper ocean currents at scales of 10-100 km in Australia's marine estate using pioneering satellite radar technology. The Surface Water and Ocean Topography (SWOT) mission will map currents at 10 times the resolution of present-day satellites and revolutionise our understanding of ocean dynamics. Expected outcomes include validation of SWOT data in Australian waters and merging this data into Bure ....Next-generation ocean current forecasting to improve maritime safety . This project aims to measure upper ocean currents at scales of 10-100 km in Australia's marine estate using pioneering satellite radar technology. The Surface Water and Ocean Topography (SWOT) mission will map currents at 10 times the resolution of present-day satellites and revolutionise our understanding of ocean dynamics. Expected outcomes include validation of SWOT data in Australian waters and merging this data into Bureau of Meteorology ocean models. Downstream benefits include improved ocean forecasts for maritime safety, search-and-rescue, spill modelling, and marine conservation. At the same time, the project will build sovereign capability in emerging remote sensing technology with a legacy beyond the life of the SWOT mission.Read moreRead less
Oxygen To Relieve Dyspnoea In Non-hypoxaemic Patients With End-stage Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$445,658.00
Summary
Chronic heart failure is a cause of suffering and a major cause of death in the Australian community. Patients who have chronic heart failure suffer from a range of symptoms that severely impacts every aspect of their life. One of the most common and distressing symptoms is breathlessness. As people with heart failure near death, their breathlessness may worsen not only in terms of its frequency, but also in its intensity. This worsening of symptoms is a source of great distress, both to patient ....Chronic heart failure is a cause of suffering and a major cause of death in the Australian community. Patients who have chronic heart failure suffer from a range of symptoms that severely impacts every aspect of their life. One of the most common and distressing symptoms is breathlessness. As people with heart failure near death, their breathlessness may worsen not only in terms of its frequency, but also in its intensity. This worsening of symptoms is a source of great distress, both to patients as well as their carers and family. Breathlessness is also the most common cause of admission to hospital for patients. A key strategy for managing this distressing symptom in the home is the supply of oxygen. However, due to a lack of scientific evidence for the benefit of home oxygen for people with heart failure, who do not necessarily have low levels of oxygen, it is very difficult for clinicians to access this therapy for their patients. This study seeks to assess if a specific breathlessness action plan alone or if the addition of either oxygen or air can relieve this distressing symptom. The scientific evaluation of these strategies will assist in improving the palliative care of people with chronic heart failure.Read moreRead less
Do The Mitochondrial Sirtuin Enzymes, SIRT3 And SIRT5, Affect Insulin Action In Skeletal Muscle?
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Metabolic disorders such as obesity, insulin resistance and type 2 diabetes are characterised by inappropriate handling of nutrients. Mitochondria are the primary site for nutrient oxidation in cells. Sirtuins such as SIRT3 and SIRT5 are abundant in mitochondria and may affect mitochondrial function and insulin action in skeletal muscle. Understanding the biochemical pathways involved in energy metabolism in skeletal muscle is crucial in the development of therapies for insulin resistance and ty ....Metabolic disorders such as obesity, insulin resistance and type 2 diabetes are characterised by inappropriate handling of nutrients. Mitochondria are the primary site for nutrient oxidation in cells. Sirtuins such as SIRT3 and SIRT5 are abundant in mitochondria and may affect mitochondrial function and insulin action in skeletal muscle. Understanding the biochemical pathways involved in energy metabolism in skeletal muscle is crucial in the development of therapies for insulin resistance and type 2 diabetes.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560930
Funder
Australian Research Council
Funding Amount
$167,777.00
Summary
Airborne laser scanning for advanced environmental monitoring. This proposal seeks to enhance the national capability for airborne remote sensing of key environmental variables through the acquisition of an airborne laser scanner and inertial navigation system. Many environmental science studies, such as hydrology, soil moisture scaling and salinity, can be significantly enhanced by airborne laser scanning, through the creation of high precision, high resolution digital terrain models. Airborne ....Airborne laser scanning for advanced environmental monitoring. This proposal seeks to enhance the national capability for airborne remote sensing of key environmental variables through the acquisition of an airborne laser scanner and inertial navigation system. Many environmental science studies, such as hydrology, soil moisture scaling and salinity, can be significantly enhanced by airborne laser scanning, through the creation of high precision, high resolution digital terrain models. Airborne laser scanning can also measure three dimensional vegetation canopy structure, a useful indicator of biomass, carbon storage and vegetation health. This infrastructure will provide Australian researchers with a unique arsenal of remote sensing tools for advanced yet affordable environmental research studies.Read moreRead less
Generation of Digital Elevation Models by Fusion of Image and Terrain Laser Scan Data. There are currently two separate approaches to obtaining digital elevation models of the terrain surface by remote sensing, image based methods using aerial or satellite images and scanner techniques by terrain laser scanners. Each method provides elevations with high accuracy, but both require significant input from an operator during processing. It is proposed to take advantage of the synegies of these two ....Generation of Digital Elevation Models by Fusion of Image and Terrain Laser Scan Data. There are currently two separate approaches to obtaining digital elevation models of the terrain surface by remote sensing, image based methods using aerial or satellite images and scanner techniques by terrain laser scanners. Each method provides elevations with high accuracy, but both require significant input from an operator during processing. It is proposed to take advantage of the synegies of these two forms of data by combining the processing into a single solution for elevation determination by data fusion. This approach will improve the quality and efficiency of elevation determination.Read moreRead less
An Integrated Ground Deformation Monitoring System Based on the Integration of InSAR, GPS and GIS Technologies. Interferometric Synthetic Aperture Radar (InSAR) can be used to monitor ground deformation at high spatial resolution. When integrated with Global Positioning Systems (GPS) so that atmospheric disturbance in InSAR result can be corrected, deformation can be resolved at sub-centimetre accuracy. The corrected InSAR result can be exported as a data layer into Geographic Information System ....An Integrated Ground Deformation Monitoring System Based on the Integration of InSAR, GPS and GIS Technologies. Interferometric Synthetic Aperture Radar (InSAR) can be used to monitor ground deformation at high spatial resolution. When integrated with Global Positioning Systems (GPS) so that atmospheric disturbance in InSAR result can be corrected, deformation can be resolved at sub-centimetre accuracy. The corrected InSAR result can be exported as a data layer into Geographic Information Systems (GIS) for further analysis. In collaboration with Hong Kong Polytechnic University researchers, the integrated InSAR-GPS-GIS system will be tested in both Hong Kong and Australia. The expected outcomes include a suite of algorithms and software tools capable of operational, cost-effective ground deformation monitoring.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560920
Funder
Australian Research Council
Funding Amount
$129,800.00
Summary
Field spectroradiometer and associated equipment for quantitative measurement and characterization of biophysical features and calibration of remotely sensed imagery. This set of equipment will improve and extend existing research capabilities in the field of in-situ remote sensing research and applications, for both aquatic and terrestrial environments. It will contribute to knowledge regarding terrestrial, coastal and estuarine vegetation and linkages to environmental change and will assist in ....Field spectroradiometer and associated equipment for quantitative measurement and characterization of biophysical features and calibration of remotely sensed imagery. This set of equipment will improve and extend existing research capabilities in the field of in-situ remote sensing research and applications, for both aquatic and terrestrial environments. It will contribute to knowledge regarding terrestrial, coastal and estuarine vegetation and linkages to environmental change and will assist in the development of new algorithms, indices and techniques of vegetation discrimination from remotely sensed imagery. It will help in the understanding of reflectance in plants under stress or pest damage. The spectroradiometer will enable the group to expand applications in the field of urban fire hazard mapping, precision agriculture, crop physiology, species mapping, viticulture and canopy modelling.Read moreRead less