Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100066
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory. Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory:
This project aims to enable Australian research leaders working on the integrated sustainability assessment of policies, products and projects to collaborate in the Industrial Ecology Virtual Laboratory (IELab). It seeks to develop and implement an enhanced modelling capability and suite of online analytical tools to support sustainability scienti ....Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory. Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory:
This project aims to enable Australian research leaders working on the integrated sustainability assessment of policies, products and projects to collaborate in the Industrial Ecology Virtual Laboratory (IELab). It seeks to develop and implement an enhanced modelling capability and suite of online analytical tools to support sustainability scientists and analysts from Australia and abroad conducting research projects of national and international significance. In particular, the project would provide policy-makers, investors and communities with detailed and tailored information to help make better decisions about a sustainable future. By upgrading IELab hardware and analytical and modelling software, the project would be versatile and flexible and remain up to date.Read moreRead less
Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is ....Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is a potential solution to both these challenges but requires new approaches to cross sector collaborations. This project aims to develop new insights, practical knowledge and practical tools for effective social procurement.Read moreRead less
Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaire ....Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaired but must be developed to identify the causes of decline. The intended outcomes are improved sustainable water resource management within and among states, and improved natural resource policy development.Read moreRead less
Violence Against Women - A Media Intervention. This project aims to by explore the link between the internal operations of news media organisations, news media outputs and their impact on community attitudes to violence against women. Current literature indicates that the paucity and tone of news reporting of violence against women perpetuates harmful attitudes towards women. International and Australian research has consistently identified community attitudes as a key causal factor in violence ....Violence Against Women - A Media Intervention. This project aims to by explore the link between the internal operations of news media organisations, news media outputs and their impact on community attitudes to violence against women. Current literature indicates that the paucity and tone of news reporting of violence against women perpetuates harmful attitudes towards women. International and Australian research has consistently identified community attitudes as a key causal factor in violence against women. However, there is a lack of research into the impact of newsroom operations, including gender politics, on news media outputs, and the impact of those outputs on community attitudes. The proposed research and intervention project seek to address this shortfall.Read moreRead less
Special Research Initiatives - Grant ID: SR0354531
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Social research network for sustainable rural communities. The triple bottom line of social, economic and environmental imperatives forms the accepted ingredients of sustainability. While the economic and environmental dimensions have been relatively well researched, there is insufficient understanding of the socio-cultural dimensions and how these determine environmental and health outcomes. The interactions between the dimensions are also poorly understood. While there are some researchers in ....Social research network for sustainable rural communities. The triple bottom line of social, economic and environmental imperatives forms the accepted ingredients of sustainability. While the economic and environmental dimensions have been relatively well researched, there is insufficient understanding of the socio-cultural dimensions and how these determine environmental and health outcomes. The interactions between the dimensions are also poorly understood. While there are some researchers in this field, they have tended to work in isolation. The development of a resourced interdisciplinary network to facilitate collaboration will increase the contribution and innovativeness of their collective research and contribute to understanding socio-economic determinants of dynamic regions and healthy rural communities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989083
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Australian Social Science Data Archive: Provision of Advanced Research Infrastructure and Collaborative Environment. The Australian Social Science Data Archive (ASSDA) supports researchers in a wide range of social science and humanities disciplines. These researchers are both primary and secondary users of data collected across a range of economic, social, political and cultural areas. Increasingly, complex public policy problems require multi-disciplinary solutions based on a range of data sou ....Australian Social Science Data Archive: Provision of Advanced Research Infrastructure and Collaborative Environment. The Australian Social Science Data Archive (ASSDA) supports researchers in a wide range of social science and humanities disciplines. These researchers are both primary and secondary users of data collected across a range of economic, social, political and cultural areas. Increasingly, complex public policy problems require multi-disciplinary solutions based on a range of data sources to address these problems. This proposal provides a means for Australia's leading edge researchers to advance the knowledge base that can lead to the development of strong evidence based policy. The open access policies of ASSDA ensures that the general public, media, non-government organisation (NGOs) and government agencies are able to examine the public use data sets that are used by researchers to arrive at their conclusions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100049
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Establishment of the Australian data archive: an integrated research facility for the social sciences and humanities. The Australian data archive will enable Australia's leading researchers to address complex social, economic and environmental problems, leading to the development of evidence based policy. The archive will have an open access policy which will ensure that the general public, media and government and non-government agencies are able to examine the data used by researchers to arriv ....Establishment of the Australian data archive: an integrated research facility for the social sciences and humanities. The Australian data archive will enable Australia's leading researchers to address complex social, economic and environmental problems, leading to the development of evidence based policy. The archive will have an open access policy which will ensure that the general public, media and government and non-government agencies are able to examine the data used by researchers to arrive at their conclusions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100141
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality c ....High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality changes, pollution histories, recent geomorphological change, land-use change, introduction of invasive species and the occurrence of bushfires. A better understanding of the occurrence and timing of these major environmental issues is of national and regional importance.Read moreRead less