Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100066
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory. Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory:
This project aims to enable Australian research leaders working on the integrated sustainability assessment of policies, products and projects to collaborate in the Industrial Ecology Virtual Laboratory (IELab). It seeks to develop and implement an enhanced modelling capability and suite of online analytical tools to support sustainability scienti ....Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory. Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory:
This project aims to enable Australian research leaders working on the integrated sustainability assessment of policies, products and projects to collaborate in the Industrial Ecology Virtual Laboratory (IELab). It seeks to develop and implement an enhanced modelling capability and suite of online analytical tools to support sustainability scientists and analysts from Australia and abroad conducting research projects of national and international significance. In particular, the project would provide policy-makers, investors and communities with detailed and tailored information to help make better decisions about a sustainable future. By upgrading IELab hardware and analytical and modelling software, the project would be versatile and flexible and remain up to date.Read moreRead less
Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is ....Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is a potential solution to both these challenges but requires new approaches to cross sector collaborations. This project aims to develop new insights, practical knowledge and practical tools for effective social procurement.Read moreRead less
Oyster biomonitor for endocrine disrupting chemicals. Endocrine disrupting chemicals (EDCs) can produce alarming detrimental impacts on the reproduction and survival of aquatic species, though little is presently known in terms of their effect and impacts on sensitive marine invertebrate species. We propose the development and validation of the first marine mollusc as a biomonitor for the detection and impact assessment of estrogenic contaminants in Australian estuarine and marine waterbodies. S ....Oyster biomonitor for endocrine disrupting chemicals. Endocrine disrupting chemicals (EDCs) can produce alarming detrimental impacts on the reproduction and survival of aquatic species, though little is presently known in terms of their effect and impacts on sensitive marine invertebrate species. We propose the development and validation of the first marine mollusc as a biomonitor for the detection and impact assessment of estrogenic contaminants in Australian estuarine and marine waterbodies. Such biomonitors will provide water management agencies with the capability to manage estrogenic effluent discharges and provide the oyster industry with a tool to prevent product contamination, ensuring the continued health and sustainability of our aquatic resources.Read moreRead less
Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaire ....Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaired but must be developed to identify the causes of decline. The intended outcomes are improved sustainable water resource management within and among states, and improved natural resource policy development.Read moreRead less
Violence Against Women - A Media Intervention. This project aims to by explore the link between the internal operations of news media organisations, news media outputs and their impact on community attitudes to violence against women. Current literature indicates that the paucity and tone of news reporting of violence against women perpetuates harmful attitudes towards women. International and Australian research has consistently identified community attitudes as a key causal factor in violence ....Violence Against Women - A Media Intervention. This project aims to by explore the link between the internal operations of news media organisations, news media outputs and their impact on community attitudes to violence against women. Current literature indicates that the paucity and tone of news reporting of violence against women perpetuates harmful attitudes towards women. International and Australian research has consistently identified community attitudes as a key causal factor in violence against women. However, there is a lack of research into the impact of newsroom operations, including gender politics, on news media outputs, and the impact of those outputs on community attitudes. The proposed research and intervention project seek to address this shortfall.Read moreRead less
Multi-Country Study on Health Effects of Bushfire Air Pollution. Catastrophic bushfires are a major natural disaster, causing serious air pollution. However, aligning bushfire air pollution and public health policies becomes a significant challenge, because limited studies are available on relationships between bushfire air pollution and human health, particularly for the prolonged exposure. We will characterize the nature of the relationships between bushfire air pollution and mortality/morbidi ....Multi-Country Study on Health Effects of Bushfire Air Pollution. Catastrophic bushfires are a major natural disaster, causing serious air pollution. However, aligning bushfire air pollution and public health policies becomes a significant challenge, because limited studies are available on relationships between bushfire air pollution and human health, particularly for the prolonged exposure. We will characterize the nature of the relationships between bushfire air pollution and mortality/morbidity by developing a multi-country study; and estimate the burden of diseases attributed to bushfire air pollution. This project will provide essential scientific evidence to policy-makers and stakeholders in the development, prioritization and implementation of health protection strategies and policies.
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Managing and mitigating social risks of major infrastructure projects. This project aims to reduce social risks of major infrastructure projects by generating an evidence-based social risk management framework. It brings together leading ANU researchers with top organisations in Australia's infrastructure sector, already working together via the ANU Institute for Infrastructure in Society. The project seeks to improve social risk management in a multi-billion dollar sector, vital to all Australi ....Managing and mitigating social risks of major infrastructure projects. This project aims to reduce social risks of major infrastructure projects by generating an evidence-based social risk management framework. It brings together leading ANU researchers with top organisations in Australia's infrastructure sector, already working together via the ANU Institute for Infrastructure in Society. The project seeks to improve social risk management in a multi-billion dollar sector, vital to all Australians. The project is significant because it adopts a sector-wide view to systematically define social risk, co-create a social risk management framework and implement it via a new social risk management toolkit. This should lessen harm to communities, reduce delays and costs and benefit national infrastructure delivery.Read moreRead less
Special Research Initiatives - Grant ID: SR0354531
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Social research network for sustainable rural communities. The triple bottom line of social, economic and environmental imperatives forms the accepted ingredients of sustainability. While the economic and environmental dimensions have been relatively well researched, there is insufficient understanding of the socio-cultural dimensions and how these determine environmental and health outcomes. The interactions between the dimensions are also poorly understood. While there are some researchers in ....Social research network for sustainable rural communities. The triple bottom line of social, economic and environmental imperatives forms the accepted ingredients of sustainability. While the economic and environmental dimensions have been relatively well researched, there is insufficient understanding of the socio-cultural dimensions and how these determine environmental and health outcomes. The interactions between the dimensions are also poorly understood. While there are some researchers in this field, they have tended to work in isolation. The development of a resourced interdisciplinary network to facilitate collaboration will increase the contribution and innovativeness of their collective research and contribute to understanding socio-economic determinants of dynamic regions and healthy rural communities.Read moreRead less