Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Spinal Cord Injury Pain: Understanding Mechanisms To Develop Treatments
Funder
National Health and Medical Research Council
Funding Amount
$597,675.00
Summary
Spinal cord injury has devastating effects on health and quality of life. Many of the major consequences of injury, such as chronic pain and loss of voluntary voiding, are "invisible" – i.e., they are not as visible as limitations of mobility. Our study aims to define the neurobiological changes that cause development of persistent pain after spinal cord injury and use pharmacological tools to attenuate the development of pain.
Rates, Patterns And Determinants Of Alcohol’s Harm To Others: A Cross-national Comparative Study
Funder
National Health and Medical Research Council
Funding Amount
$305,856.00
Summary
Alcohol causes harms to drinkers, and others around them, including spouses, children, family, friends, workmates and strangers. Australian and New Zealand work on alcohol’s harm to others is being replicated by the WHO in 7 countries (Chile, Nigeria, Sri Lanka, India, Thailand, Laos and Vietnam). We aim to analyse datasets from nine countries and compare the magnitude and patterning of problems across and within cultures – identifying opportunities for reducing harm from others’ drinking.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Deeper and broader life cycle risk assessment - extending the frontier for hybrid methodologies. This project is about combining detailed and global perspectives of environmental health risk from different fields of planning practice. It aims to improve the depth and breadth of the types of information used by government regulators and the community in decisions about the development of capital works.
Developing the capacity to model the impact of interventions that target high-risk drinking among young Australians. Alcohol use is a major contributing factor to social and health problems among young Australians. The project will inform the development of effective policy by providing multidisciplinary research evidence and the capacity to model how various interventions impact on the prevalence of alcohol-related problems.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100066
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory. Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory:
This project aims to enable Australian research leaders working on the integrated sustainability assessment of policies, products and projects to collaborate in the Industrial Ecology Virtual Laboratory (IELab). It seeks to develop and implement an enhanced modelling capability and suite of online analytical tools to support sustainability scienti ....Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory. Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory:
This project aims to enable Australian research leaders working on the integrated sustainability assessment of policies, products and projects to collaborate in the Industrial Ecology Virtual Laboratory (IELab). It seeks to develop and implement an enhanced modelling capability and suite of online analytical tools to support sustainability scientists and analysts from Australia and abroad conducting research projects of national and international significance. In particular, the project would provide policy-makers, investors and communities with detailed and tailored information to help make better decisions about a sustainable future. By upgrading IELab hardware and analytical and modelling software, the project would be versatile and flexible and remain up to date.Read moreRead less
Cyber-racism and community resilience. Racism has become a significant source of social stress, facilitated through the internet, undermining community cohesion. This project will document perpetrators’ creation of racist content, internet users’ exposure to cyber-racism, the capacity of regulation to manage the impact, and how social media can help communities to resist cyber-racism.
Improving employment outcomes for Australians with disability. This project aims to provide evidence about how to improve employment outcomes for people with disability. Nearly one in five adult Australians have a disability and just over half of these are in the labour force; a modest increase in employment rates will have significant social and economic benefits for people with disability and society. By collecting longitudinal quantitative (survey) and qualitative (interview) data at three ti ....Improving employment outcomes for Australians with disability. This project aims to provide evidence about how to improve employment outcomes for people with disability. Nearly one in five adult Australians have a disability and just over half of these are in the labour force; a modest increase in employment rates will have significant social and economic benefits for people with disability and society. By collecting longitudinal quantitative (survey) and qualitative (interview) data at three time points from over 1500 jobseekers with disability, critical information should be gained about how the characteristics of employment services, workplaces and jobseekers contribute to sustainable, meaningful employment for people with disability.Read moreRead less
Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is ....Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is a potential solution to both these challenges but requires new approaches to cross sector collaborations. This project aims to develop new insights, practical knowledge and practical tools for effective social procurement.Read moreRead less