Centre For Research Excellence In Speech And Language Neurobiology (CRE-SLANG)
Funder
National Health and Medical Research Council
Funding Amount
$2,491,340.00
Summary
Half a million Australian children have a speech/language disorder, tripling their changes of poor academic outcomes, limited employment options and social isolation. Current speech therapy is limited, focusing on symptoms and ignoring evidence on underlying aetiologies. By identifying and translating findings on new genes and brain pathways leading to speech and language disorders, we will transform detection, diagnosis, prognosis and genetic counselling of affected children and their families.
How Language Develops, What Goes Wrong, And Why It Matters: Following The Early Language In Victoria Study To Age 13
Funder
National Health and Medical Research Council
Funding Amount
$857,242.00
Summary
One in five children start school with low language. Little is known about the long term effects on developmental, educational attainment and other outcomes later in life. In this landmark study we will track the children's language, literacy and wellbeing from ages 8 to 12 years. We will capture the children's ability as they finish their primary school education and prior to the crucial transfer to high school.
A novel link between plant pathogen defence and DNA repair capability. Plants and plant-based industries are essential for the provision of food, clothing and building materials and underpin the economies of rural communities. Plant yield and quality and the biodiversity of natural systems are dramatically reduced by disease. The fundamental knowledge gained from our research will enable manipulation of the factors that enhance disease resistance resulting in a significant benefit to Australian ....A novel link between plant pathogen defence and DNA repair capability. Plants and plant-based industries are essential for the provision of food, clothing and building materials and underpin the economies of rural communities. Plant yield and quality and the biodiversity of natural systems are dramatically reduced by disease. The fundamental knowledge gained from our research will enable manipulation of the factors that enhance disease resistance resulting in a significant benefit to Australian agriculture and protection of our natural resources. The current reliance for disease control on chemicals that damage the environment will be reduced and our research will contribute directly to the provision of cheaper, simpler and more effective methods of control.
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Novel biological and genetic disease control tools for the barley industry. This project places Australian barley breeders at the forefront of disease resistance by providing them with novel tools to develop varieties with enhanced protection against fungal diseases. The aims are to produce fungal strains with multiple virulence genes for fast and cost-effective testing of barley lines, untangle the fungal/host gene interaction for resistance breeding and identify new sources of resistance. The ....Novel biological and genetic disease control tools for the barley industry. This project places Australian barley breeders at the forefront of disease resistance by providing them with novel tools to develop varieties with enhanced protection against fungal diseases. The aims are to produce fungal strains with multiple virulence genes for fast and cost-effective testing of barley lines, untangle the fungal/host gene interaction for resistance breeding and identify new sources of resistance. The outcomes will lead to the commercialisation by Australian breeding companies of barley varieties with durable fungal resistance. This will benefit the Australian economy by providing sustainability and protection for barley breeding thereby significantly reducing crop losses for this important global agricultural commodity.Read moreRead less
My enemy’s enemy is my friend: The genetics of major plant pathogen killers. Fungi are devastating agents of crop diseases. These plant pathogens, in turn, are often parasitized by other fungi in the field. The project will focus on such interactions between powdery mildews, important pathogens of many crops and wild plants, and their common fungal parasites (Ampelomyces spp.) that have already been utilised as
biocontrol agents in crop protection. Genetic and genomic tools will be used to deter ....My enemy’s enemy is my friend: The genetics of major plant pathogen killers. Fungi are devastating agents of crop diseases. These plant pathogens, in turn, are often parasitized by other fungi in the field. The project will focus on such interactions between powdery mildews, important pathogens of many crops and wild plants, and their common fungal parasites (Ampelomyces spp.) that have already been utilised as
biocontrol agents in crop protection. Genetic and genomic tools will be used to determine if these parasites evolved by switching host from plants to plant pathogens. The project has the potential to make a ground-breaking discovery in this field, and also establish the starting point for new innovative methods to protect a wide diversity
of crops using these fungi or specific compounds derived from them.Read moreRead less
Mediator: a new concept for controlled gene expression in plant biotechnology. The Mediator protein complex is a new control point for the activation of all genes in higher organisms and the purpose of this project is to understand how three Mediator subunits regulate disease resistance in plants. The outcomes provide a new concept to direct natural gene expression towards robust crop plants able to cope with climatic variations.