Improving Neurobehavioural Development In Preterm Infants: A Randomised Controlled Trial Of A Neonatal Intervention
Funder
National Health and Medical Research Council
Funding Amount
$680,920.00
Summary
Up to 50% of preterm infants will have one or more developmental difficulties. While medical complications are implicated in these problems, recent evidence points to the added effect of the infant's early environment. Hospitalised premature infants experience stress from necessary but painful hospital procedures, overstimulation and maternal deprivation. Evidence, largely from animal studies, suggests stressful early experience negatively affects brain development. We also know that premature i ....Up to 50% of preterm infants will have one or more developmental difficulties. While medical complications are implicated in these problems, recent evidence points to the added effect of the infant's early environment. Hospitalised premature infants experience stress from necessary but painful hospital procedures, overstimulation and maternal deprivation. Evidence, largely from animal studies, suggests stressful early experience negatively affects brain development. We also know that premature infants find it difficult to handle stress as they are highly disorganised neurobehaviourally. The primary aim of this study is to assess the effectiveness of a parent-based intervention in enhancing neurobehavioural development at two years of age in very premature infants. It is predicted that this stress-reduction intervention will also enhance medical stability,normal brain development, parent-child interaction and parental mental health. The intervention to be trialled involves intensive training of parents of very premature infants, and in the 12 weeks following birth the parents will be the change agents. A randomised controlled trial comparing intervention and control groups will be undertaken to assess the effectiveness of this intervention. Assessments of early brain and 2 year intellectual, emotional and behavioural development will provide important outcome measures. A major strength of this study is the inclusion of advanced Magnetic Resonance Imaging (MRI) technology as it enables differences in brain development between the intervention and control group to be assessed, the association between brain and neurobehavioural development to be explored, and the impact of stress on early brain development to be investigated. This intervention is relatively simple and inexpensive, and would be a valuable contribution to neonatal care if found to be effective in enhancing brain and neurobehavioural development.Read moreRead less
Suicide prevention and management of deliberate self-harm: randomised control trial of an assertive engagement, brief psychotherapy and community linkage model. Suicide is the second commonest cause of death by injury in Australia. Suicide prevention is an important public health priority but rates remain high. People who have previously attempted suicide are most likely to kill themselves. Most suicidal people attend emergency departments where they get inadequate treatment for their psychologi ....Suicide prevention and management of deliberate self-harm: randomised control trial of an assertive engagement, brief psychotherapy and community linkage model. Suicide is the second commonest cause of death by injury in Australia. Suicide prevention is an important public health priority but rates remain high. People who have previously attempted suicide are most likely to kill themselves. Most suicidal people attend emergency departments where they get inadequate treatment for their psychological and social problems and remain depressed and suicidal. This project will test the effectiveness of a new psychological and social treatment to reduce the depression and link suicidal people with community supports. If successful, this treatment could be provided in any emergency department and help decrease suicide rates in Australia.Read moreRead less
Discovery Indigenous Researchers Development - Grant ID: DI110100034
Funder
Australian Research Council
Funding Amount
$300,401.00
Summary
Measurement matters: analysis of potential methodological and discrimination biases in assessments of medication treatments for ADHD, and stakeholder views. This research aims to identify multiple stakeholders' views of the nature of Attention Deficit Hyperactivity Disorder and test if discrimination and survey wording result in bias when assessing the impact of medical treatments. This will result in understandings of discrimination and measurement bias; multiple stakeholders' perceptions; and ....Measurement matters: analysis of potential methodological and discrimination biases in assessments of medication treatments for ADHD, and stakeholder views. This research aims to identify multiple stakeholders' views of the nature of Attention Deficit Hyperactivity Disorder and test if discrimination and survey wording result in bias when assessing the impact of medical treatments. This will result in understandings of discrimination and measurement bias; multiple stakeholders' perceptions; and better methodology in research.
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Developing useable markers of mental health deterioration. The project aims to improve risk management in mental health. Risk management in mental health is currently hampered because there is no nationally agreed set of markers of deterioration. One strand of the project aims to improve safety procedures by identifying the bases of decisions about adverse outcomes (i.e. symptom deterioration) and testing this knowledge to understand and predict other adverse events (e.g. non-suicidal self-injur ....Developing useable markers of mental health deterioration. The project aims to improve risk management in mental health. Risk management in mental health is currently hampered because there is no nationally agreed set of markers of deterioration. One strand of the project aims to improve safety procedures by identifying the bases of decisions about adverse outcomes (i.e. symptom deterioration) and testing this knowledge to understand and predict other adverse events (e.g. non-suicidal self-injury). A second strand aims to improve prediction of clinical deterioration and non-suicidal self-injury. By identifying ways to inform and implement decisions about risk management, the project intends to lay a foundation for the development of a nationally agreed set of markers for mental health deterioration to be used in occupational safety and health processes.Read moreRead less
Predicting the evolution of psychosocial and cognitive difficulties in epilepsy: A preventive approach. Chronic epilepsy is associated with significant psychosocial and cognitive difficulties. Research has neglected to examine how these problems evolve from the time of a first seizure, limiting our ability to predict ?at risk? patients and apply evidence-based preventive strategies. We will follow a cohort of 90 first seizure patients over two years in a prospective longitudinal investigation, m ....Predicting the evolution of psychosocial and cognitive difficulties in epilepsy: A preventive approach. Chronic epilepsy is associated with significant psychosocial and cognitive difficulties. Research has neglected to examine how these problems evolve from the time of a first seizure, limiting our ability to predict ?at risk? patients and apply evidence-based preventive strategies. We will follow a cohort of 90 first seizure patients over two years in a prospective longitudinal investigation, mapping psychosocial and cognitive change. This study entails a multidisciplinary collaboration with industry, applying innovative psychosocial and cognitive measures that will ultimately improve the detection of adverse pharmaceutical side-effects. The project is an international first, and will provide an important foundation for implementing preventive healthcare.Read moreRead less
Evaluation of treatment outcomes for court-referred and voluntary clients in residential and outclient substance abuse treatment programs. Very little research has been conducted evaluating the relative effectiveness of substance abuse treatment programs for court-referred clients, compared with voluntary clients. This project will obtain psychological, social and health measures in order to compare short- and long-term treatment outcomes. Its significance lies not only in its potential to evalu ....Evaluation of treatment outcomes for court-referred and voluntary clients in residential and outclient substance abuse treatment programs. Very little research has been conducted evaluating the relative effectiveness of substance abuse treatment programs for court-referred clients, compared with voluntary clients. This project will obtain psychological, social and health measures in order to compare short- and long-term treatment outcomes. Its significance lies not only in its potential to evaluate the success of treatment for clients diverted from the criminal justice system, but also in its unique focus on a wide range of outcomes for different client groups.Read moreRead less
Understanding effective and satisfying communication between health providers and patients and its relationship with health outcomes. This project investigates the components of satisfying and effective consultations for both health professionals and patients, and their relationship with good health outcomes. This project takes an intergroup theoretical perspective to examine interpersonal interactions between health providers and patients. It examines differences in perceptions of role and co ....Understanding effective and satisfying communication between health providers and patients and its relationship with health outcomes. This project investigates the components of satisfying and effective consultations for both health professionals and patients, and their relationship with good health outcomes. This project takes an intergroup theoretical perspective to examine interpersonal interactions between health providers and patients. It examines differences in perceptions of role and communication strategies between in health professionals from different disciplines and between a broad range of patients types.Read moreRead less
Chronic pain and functional impairment following traumatic injury: an investigation into the impact of compensation status and experience. This project will enhance understanding of the impact of the psychosocial factors and the compensation process on recovery from traumatic injury. The project will generate new resources (screening and referral guidelines; educational materials) to improve decision making consistency, client experience, and recovery from road trauma.
Sleep and speech: objectively monitoring the residual effects of sleep promoting compounds. This project will benefit the one in 11 Australians with sleep difficulties. The project will improve how the safety of drugs for insomnia are evaluated by examining the changes in our speech that occur when we are impaired. The findings are expected to reduce the cost of accidents and injuries due to impairment from sleep medications.