Under this fellowship the applicant will study a n important group of enzymes and molecular delivery machines involved in clotting disease, immune dysfunction and cancer.
Understanding How Perforin Forms Pores: The Role Of Calcium And Lipids.
Funder
National Health and Medical Research Council
Funding Amount
$797,813.00
Summary
This grant aims to study perforin, a key part of the mammalian immune system. The work will facilitate the development of perforin inhibitors. It is anticipated that these data will be of utility in developing first in class drugs to improve the success of bone marrow transplantation.
Structural Studies On The Immune Effector Perforin: Developing Mechanism-based Inhibitors
Funder
National Health and Medical Research Council
Funding Amount
$1,116,594.00
Summary
Perforin is an essential weapon deployed by the human immune cells in order to destroy virally infected or cancerous cells. Despite this key role, unwanted or excessive perforin function can result in disease and can severely impact on successful treatment of leukaemia through bone marrow transplantation. This application aims to understand the molecular details of perforin function, and to apply this knowledge to develop perforin inhibitors.