Using Metagenomics To Determine The Causative Agent(s) Of Tick-Borne Disease In Australia
Funder
National Health and Medical Research Council
Funding Amount
$639,428.00
Summary
Tick-borne disease has emerged as a topical and controversial public health problem in Australia. We will employ state-of-the-art techniques in metagenomics to determine what microbial species (bacteria, viruses and eukaryotes) circulate in Australian ticks and whether these or different microbes are also present in humans diagnosed with tick-borne disease. The data generated will provide key information on whether tick-borne disease has a microbiological cause and, if so, the microbes involved.
Molecular Networks And Genomics Of Host Response In Typhoid Fever
Funder
National Health and Medical Research Council
Funding Amount
$487,814.00
Summary
Typhoid fever affects 25 million people annually and is caused by systemic infection with Salmonella Typhi or Paratyphi. With this proposal, we will characterise how different individuals respond differently to typhoid, what ramifications this has for systemic Salmonella infection in humans, and how typhoid can be clinically identified early on, thus giving the patient the best possible chance to avoid complications, injury and potential death.