A new scan called PiB PET shows the build up of amyloid protein deposits in the brain in all patients with Alzheimer's disease (AD) but also in 30% of normal elderly persons. This study will track the build up of amyloid and clinical progress in 280 elderly Australians to confirm that this scan can detect AD before symptoms and investigate factors that influence this build up and its damaging effects on memory and thinking. Early detection of Alzheimer's disease will assist accurate diagnosis an ....A new scan called PiB PET shows the build up of amyloid protein deposits in the brain in all patients with Alzheimer's disease (AD) but also in 30% of normal elderly persons. This study will track the build up of amyloid and clinical progress in 280 elderly Australians to confirm that this scan can detect AD before symptoms and investigate factors that influence this build up and its damaging effects on memory and thinking. Early detection of Alzheimer's disease will assist accurate diagnosis and the development of treatment.Read moreRead less
Finding The Optimum Target And Predictors Of Outcome In Deep Brain Stimulation Of Older Patients With Parkinsons Disease
Funder
National Health and Medical Research Council
Funding Amount
$428,392.00
Summary
Parkinson's disease treatment has been revolutionised by the advent of deep brain stimulator surgery. The major benefits come from improved motor function and quality of life. We aim to test the relative benefits of two different targets for brain stimulation and compare their effects on quality of life and cognition. We will also use some of Australia's expertise in brain scanning technology to look for pre-operative predictors of treatment outcomes in this group of older patients with PD.