IDENTIFICATION OF BRAIN NEURONS INVOLVED IN THE CARDIOVASCULAR RESPONSE TO FEAR AND FLIGHT
Funder
National Health and Medical Research Council
Funding Amount
$400,247.00
Summary
The circulatory system of the body acts in concert with the respiratory system to distribute oxygenated blood to the brain and other organs and tissues of the body. Control of blood pressure and heart rate is achieved largely through the actions of the central nervous system on effector organs and tissues such as the heart and blood vessels. This control is exerted through the actions of nerves in the body which affect the rate and force of contraction of the heart and the diameter of blood vess ....The circulatory system of the body acts in concert with the respiratory system to distribute oxygenated blood to the brain and other organs and tissues of the body. Control of blood pressure and heart rate is achieved largely through the actions of the central nervous system on effector organs and tissues such as the heart and blood vessels. This control is exerted through the actions of nerves in the body which affect the rate and force of contraction of the heart and the diameter of blood vessels which restrict the flow of blood to the tissues. These nerves, in turn, are under the control of brain cells or neurons which are located in the brainstem. Blood pressure-controlling neurons, acting upon information they receive from pressure sensors in the major blood vessels in the chest cavity, can alter their activity so that blood pressure is maintained within normal limits. Our laboratory has been examining the properties of these blood pressure-controlling neurons by recording their minute electrical discharges and by studying other brain regions which are able to influence them. In this study, we will use newly-developed procedures which will allow us to identify the precise locations of these neurons in the brain, to study which neurotransmitters (chemicals released by neurons which are used to communicate with other neurons) they use, as well as to identify other regions of the brain they connect with and influence. The major significance of this work will be that new brain circuits which transmit information about the status of the cardiovascular system to other areas of the brain will be identified. Our understanding of, and the development of new treatments for, cardiovascular diseases such as high blood pressure and heart failure are critically dependent on advancing our understanding of the nervous system.Read moreRead less
Rethinking housing: network analysis for digital collaboration. This project aims to understand persistent housing sector supply problems through analysis of digital collaborative practices. This project expects to generate new knowledge for an emerging housing digital economy using interdisciplinary network theory and data visualisation techniques. The housing sector has long been criticised for shortcomings in affordability, efficiency, quality, social and environmental responsiveness and appr ....Rethinking housing: network analysis for digital collaboration. This project aims to understand persistent housing sector supply problems through analysis of digital collaborative practices. This project expects to generate new knowledge for an emerging housing digital economy using interdisciplinary network theory and data visualisation techniques. The housing sector has long been criticised for shortcomings in affordability, efficiency, quality, social and environmental responsiveness and appropriateness of offerings. Expected outcomes include enhanced housing supply professionals' capability, improved knowledge among public/private sector decision makers responsible for housing supply and development of new digital collaborative behavioural theoretical and practical frameworks for the sector.Read moreRead less
Efficient construction: analysis of integrated supply chains for innovative off site housing manufacturing. The Australian housing industry is failing to meet demand. Housing construction is too slow, as indicated by a 40 per cent increase in average construction time over the last fifteen years. Industry fragmentation is an oft-cited cause of construction inefficiency. A solution is offsite manufacturing. Australia lags other countries in adoption of off-site manufacturing. To achieve adoption ....Efficient construction: analysis of integrated supply chains for innovative off site housing manufacturing. The Australian housing industry is failing to meet demand. Housing construction is too slow, as indicated by a 40 per cent increase in average construction time over the last fifteen years. Industry fragmentation is an oft-cited cause of construction inefficiency. A solution is offsite manufacturing. Australia lags other countries in adoption of off-site manufacturing. To achieve adoption and diffusion, fragmentation needs to be addressed. This project aims to analyse the factors affecting supply chain integration to support innovative offsite manufacturing and develop a novel collaborative practice based implementation model.Read moreRead less
Safe and healthy construction: the influence of clients in driving improvement through construction procurement and project management practices. The project will measure the impact that the construction industry's clients can exert over the workplace health and safety (WHS) performance of projects. The project will identify client actions that have a positive impact upon WHS and will help embed WHS management practices in the procurement of major infrastructure construction projects.
An experimental evaluation of the usefulness of computer-supported argumentation to improve occupational health and safety in construction design. The research investigates the potential for experts' occupational health and safety (OHS) reasoning to be reproduced in a knowledge-based system and used to: (i) augment the OHS decision-making of construction design professionals; and (ii) develop design OHS capability, especially in novices. The results will support the implementation of OHS policy ....An experimental evaluation of the usefulness of computer-supported argumentation to improve occupational health and safety in construction design. The research investigates the potential for experts' occupational health and safety (OHS) reasoning to be reproduced in a knowledge-based system and used to: (i) augment the OHS decision-making of construction design professionals; and (ii) develop design OHS capability, especially in novices. The results will support the implementation of OHS policy in the construction industry.Read moreRead less
Maximising the value of alliances in delivering infrastructure projects: a mixed methods management study of procurement innovation. Australia’s new infrastructure is currently being delivered inefficiently. The project will take a novel approach to improving efficiency, focusing on cooperation within construction teams. The project will develop new mechanisms to align incentives and capabilities within construction teams.
Population Health Planning For Rural Medicare Locals: Evaluating A Community Participation Method For Delivering Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$438,587.00
Summary
The study, in six communities, will evaluate whether an evidenced based method of rural community participation from the UK translates to assist healthcare planning by Medicare Locals. Medicare Locals must involve local people in designing services to improve health, but lack methods to do this. The focus of the study is oral health, a major issue in rural areas. The study evaluates whether new services are designed and implemented and whether there is change to health knowledge and behaviours.
The team has been at the forefront of research on type 1 diabetes for over a decade. This form of diabetes is a major chronic disease from childhood, as well as accounting for at least 10% of adult-onset diabetes. It occurs when the body�s immune system attacks and destroys the beta cells in the pancreas that make insulin, the hormone that controls the level of glucose in the blood. The team was one of the first in the world, and is the only one in Australia, to develop screening programs to tes ....The team has been at the forefront of research on type 1 diabetes for over a decade. This form of diabetes is a major chronic disease from childhood, as well as accounting for at least 10% of adult-onset diabetes. It occurs when the body�s immune system attacks and destroys the beta cells in the pancreas that make insulin, the hormone that controls the level of glucose in the blood. The team was one of the first in the world, and is the only one in Australia, to develop screening programs to test and identify people at risk for type 1 diabetes. They showed that the underlying disease could start years before symptoms occurred and discovered genes that determine the rate at which the underlying disease progresses. They have also found evidence that the disease may be triggered by gut viruses called rotaviruses in genetically-susceptible individuals. They showed that type 1 diabetes could be prevented in a mouse model by getting the immune system to make a protective response to insulin, and then went on to apply this in at-risk humans in a controlled trial of intranasal insulin, the first of its kind. They have used genetic techniques not only to pinpoint the mechanisms responsible for killing the beta cells but also to modify the beta cells to make them resistant to attack by these mechanisms. The multidisciplinary approach of the team will be directed to further understanding the genetic and environmental factors underlying type 1 diabetes and the immune mechanisms, particularly involving special white blood cells called T cells, that kill beta cells. A molecular target of the immune attack, the parent of insulin called proinsulin, will be used, paradoxically, as a tool to regulate the immune system and avert the attack. This will be achieved by giving proinsulin via the mucosa of the naso-respiratory tract or via the bone marrow-derived stem cells, initiallyin the mouse model as a test of feasibility for human application. In parallel with these approaches to prevention, specially constructed viruses will be used to transfer several new genes into beta cells to improve their resistance to immune attack, so that they can be transplanted into people with established diabetes without the need for potentially toxic drugs that suppress the immune system overall. The integrated research of the team is helping to provide a sound, rational base for the eventual prevention and cure of type 1 diabetes.Read moreRead less
Greening procurement of infrastructure construction: optimising mass-haul operations to reduce greenhouse gas emissions. This project will develop and prototype tools to reduce the high environmental impact of mass haul operations in road and rail infrastructure projects. Both contractors and clients need practical methods for calculating, optimising and procuring optimal solutions, because mass haul is one of the few areas where a contractor can reduce carbon dioxide impact.