The Efficacy Of Adjunctive S-Adenosyl Methionine (SAMe) Versus A Combination Nutraceutical In Clinical Depression: A Double-Blind, Randomised, Placebo-Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$800,264.00
Summary
An emerging approach to treat depression is via the use of adjunctive nutraceuticals (nutrient-based natural products). Specific antidepressant nutraceuticals can target a range of key neurological pathways that can treat depression. We are conducting an 8 week clinical trial comparing the efficacy of a range of nutraceuticals- such as folic acid, omega-3, and zinc, in adults with depression who are non-responsive to current pharmaceutical antidepressants.
Investigation Of Australian And Papua New Guinean Traditional Medicines For Drug Discovery And Cultural Preservation
Funder
National Health and Medical Research Council
Funding Amount
$373,751.00
Summary
This project addresses the growing need for new antimicrobial agents by utilising the traditional medicinal floral knowledge of indigenous communities of Australia and Papua New Guinea. Discoveries from the biological and chemical investigations of traditional medicines used by these communities for treatment of microbial infections will indicate their potential to be used as clinical agents. Benefit sharing and capability building opportunities for the communities involved will also be key outc ....This project addresses the growing need for new antimicrobial agents by utilising the traditional medicinal floral knowledge of indigenous communities of Australia and Papua New Guinea. Discoveries from the biological and chemical investigations of traditional medicines used by these communities for treatment of microbial infections will indicate their potential to be used as clinical agents. Benefit sharing and capability building opportunities for the communities involved will also be key outcomes.Read moreRead less
Towards Reducing The Susceptibility Of “high Risk” Infants To Allergic Asthma By Therapeutic Modulation Of Immunoregulatory Functions In The Pregnant Mother.
Funder
National Health and Medical Research Council
Funding Amount
$445,681.00
Summary
This project will deliver information in relation to the potential use and underlying modes of action of a therapeutic agent fed to pregnant mothers at high risk for atopic children, to protect against allergic asthma development in their offspring. Furthermore, the project will address the benefits of this therapeutic agent in relation to protection against inflammation induced preterm birth.
A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
The Prophylactic Hypothermia To Lessen Traumatic Brain Injury-randomised Controlled Trial : Continuation Of Funding Request
Funder
National Health and Medical Research Council
Funding Amount
$266,321.00
Summary
Traumatic brain injury (TBI) is a major cause of death and long term disability. About half with severe TBI will die or have a poor outcome. The social and economic costs to the community are high. Treatment focuses on optimising oxygen and blood flow to the brain. Cooling may protect the brain. POLAR is a randomised trial of early cooling in patients with TBI. Cooling is started within 3 hours of injury. Data about the injury management and safety is collected. Recovery is measured at 6 months.
Re-EValuating The Inhibition Of Stress Erosions (REVISE): Gastrointestinal Bleeding Prophylaxis In ICU
Funder
National Health and Medical Research Council
Funding Amount
$2,955,164.00
Summary
Around 50,000 patients in Australian Intensive Care Units receive a drug called pantoprazole each year with the aim of preventing bleeding from the gut. Recent research suggests this practice is ineffective and may harm patients by increasing their risk of serious infections. We will perform a definitive study to determine whether the widespread use of pantoprazole is beneficial or harmful.
A Phase IIb Randomised Controlled Trial Of Continuous Beta-lactam Infusion Compared With Intermittent Beta-lactam Dosing In Critically Ill Patients With Severe Sepsis
Funder
National Health and Medical Research Council
Funding Amount
$947,371.00
Summary
This randomised controlled trial aims to compare, in critically-ill patients with severe sepsis managed in the intensive care unit, whether the administration of beta-lactam antibiotics via continuous infusion improves outcomes for patients compared with standard intermittent dosing. The potential significance of this step-wise research program is that it may lead to a simple and cost-effective intervention to improve ICU-free days, clinical cure and survival for patients with severe infections.
The RINSE Trial: The Rapid Infusion Of Cold Normal SalinE By Paramedics During CPR
Funder
National Health and Medical Research Council
Funding Amount
$708,241.00
Summary
Sudden cardiac arrest is a common event in the community. Therapeutic hypothermia decreases the brain injury caused by the cardiac arrest and is currently used in the hospital after successful resuscitation. However, there may be better outcomes if the brain is cooled by paramedics during resuscitation. We will compare survival rates for those patients cooled early by paramedics using an infusion of ice-saline during cardiac arrest with those patients who are later cooled by the hospital.
Longitudinal Characterization Of Respiratory And Immune Development From Birth To Adulthood In The Perth Respiratory Birth Cohort
Funder
National Health and Medical Research Council
Funding Amount
$528,885.00
Summary
The Perth Respiratory Birth Cohort Study began in 1987 and has assessed 253 children before birth and at follow-up at 1, 6 & 12 months, and 6, 11 & 18 years of age. The study has resulted in 63 publications and achieved consistent international prominence. The proposed study of the cohort at 24 yrs aims to determine the respiratory and immunological status of the cohort as young adults. This follow-up is essential to determine how early risk factors affect respiratory outcome in young adults.
Improving The Neonatal Transition In Infants With A Congenital Diaphragmatic Hernia
Funder
National Health and Medical Research Council
Funding Amount
$551,644.00
Summary
Congenital diaphragmatic hernia is a common congenital abnormality and occurs when the diaphragm fails to separate the abdominal and thoracic compartments before birth. This prevents the lung from growing properly and so at birth, the lung is unable to take over the role of gas exchange without considerable assistance. As a result, these infants are at high risk of death or significant disability and this application is focused on improving care and reducing morbidity in these infants.