A New Direction For TB Control In Highly Endemic Countries: A RCT Of Active Case Finding
Funder
National Health and Medical Research Council
Funding Amount
$1,362,910.00
Summary
Tuberculosis is the number 1 health problem in Vietnam . Many people with TB do not know they have the disease but are infectious to others. Hence, the disease continues to spread. This project will investigate the role of x-ray screening to detect and treat more people with TB, particularly those who do not have symptoms. This may be an important element of future TB control programs in Vietnam and elsewhere in our region.
Does Fresh Frozen Plasma In Russells Viper Bite Coagulopathy Reduce The Dose And Duration Of Antivenom Therapy?
Funder
National Health and Medical Research Council
Funding Amount
$622,344.00
Summary
This proposal seeks funding to undertake a trial of clotting factor replacement with low dose antivenom therapy in snake bite coagulopathy in Sri Lanka. The aim is to determine if factor replacement will result in a rapid return of clotting function, allow a smaller dose of antivenom and therefore reduce the potential risk of major bleeding and reactions to antivenom. This study will have international implications because globally snakebite coagulopathy is a major cause of morbidity and death .
Invasive fungal infections are a serious, escalating health issue. They cause severe disease with high death rates and are very costly to the health system. Current drugs often have suboptimal efficacy and cause side effects. New drugs are needed urgently. Many fungi, including the AIDS-related pathogen, Cryptococcus neoformans, secrete phospholipase B (Plbp) to facilitate infection. We will identify and investigate the Plbp secretion pathway as a novel anti-fungal drug target.
A Randomized Clinical Trial Comparing Effectiveness Of 4RIF And 9INH For Treatment Of Latent TB Infection
Funder
National Health and Medical Research Council
Funding Amount
$496,875.00
Summary
Treatment of latent tuberculosis infection (LTBI) is one intervention that is known to prevent the occurrence of active TB. Current treatment is based on a six to nine month course of isoniazid. The treatment has side effects in some people and many people do not complete the treatment. The present study is to test an alternative treatment regimen (4 months of rifampicin) which has fewer side-effects and is more likely to be completed.
Impact Of An Ivermectin Mass Drug Administration Program Against Endemic Scabies And Strongyloidiasis
Funder
National Health and Medical Research Council
Funding Amount
$1,289,786.00
Summary
Overseas studies suggest sustainable and long term benefits can be obtained through the use of ivermectin in mass drug administration programs to control parasitic infections. Our study will be a critical first step in establishing if such a program can be successful in a remote Indigenous community setting, where the disease burden from scabies and strongyloidiasis (threadworm infections) is very high.
Eucalypt growth in past and future environments - a novel approach to understanding the impacts of atmospheric CO2 and climate. The impact of climate change and rising atmospheric CO2 on Australia's plantation and native forests is a major concern for government and land managers. These forests are important for environmental, aesthetic, and economic purposes, including carbon sequestration and trading. Forests use large amounts of water, reducing stream flow and water supplies for rural and u ....Eucalypt growth in past and future environments - a novel approach to understanding the impacts of atmospheric CO2 and climate. The impact of climate change and rising atmospheric CO2 on Australia's plantation and native forests is a major concern for government and land managers. These forests are important for environmental, aesthetic, and economic purposes, including carbon sequestration and trading. Forests use large amounts of water, reducing stream flow and water supplies for rural and urban communities. Knowledge generated from the proposed project will provide insight into mechanisms driving productivity and water use of forests in current and future environments. The knowledge will be used by land managers and government to develop strategies to cope with future impacts of climate change.Read moreRead less
Quantifying tree and soil respiration and their responses to global change. The Australian Greenhouse Office, as well as independent analysis, recognizes that belowground processes must be better quantified if Australia's contributions to atmospheric concentrations of greenhouse gases (GG) are to be firmly based. A major issue is the lack of dedicated research focused on soil and plant root emissions of GG and, in particular, a lack of testing of methodologies suited to Australian soils and con ....Quantifying tree and soil respiration and their responses to global change. The Australian Greenhouse Office, as well as independent analysis, recognizes that belowground processes must be better quantified if Australia's contributions to atmospheric concentrations of greenhouse gases (GG) are to be firmly based. A major issue is the lack of dedicated research focused on soil and plant root emissions of GG and, in particular, a lack of testing of methodologies suited to Australian soils and conditions. This project will address these concerns. We will also be addressing the clear need for further training of PhD qualified researchers in the field of climate change. Read moreRead less
How will Eucalypt tree architecture and growth adapt to future atmospheric CO2 and drought? This work is fundamental to understanding how growth and water use by Australia's forests will be modified in the future by global change. The changes in tree leaf area and canopy structure that we seek to understand will determine forest responses to increasing atmospheric CO2 and drought. It is essential to study these changes on Australian species, because they differ from forest species elsewhere in h ....How will Eucalypt tree architecture and growth adapt to future atmospheric CO2 and drought? This work is fundamental to understanding how growth and water use by Australia's forests will be modified in the future by global change. The changes in tree leaf area and canopy structure that we seek to understand will determine forest responses to increasing atmospheric CO2 and drought. It is essential to study these changes on Australian species, because they differ from forest species elsewhere in having been largely shaped by water availability. This fundamental work will flow into predictions of future forest growth and water use in Australia, with consequences for land and water resource management as well as forestry.Read moreRead less
450 Million year history of plant gas exchange capacity and the role of atmospheric carbon dioxide. Our planet faces an increase in atmospheric carbon dioxide that is unprecedented in human history, but has occurred in ancient times. By studying the relationship between past changes in atmospheric carbon dioxide, plant gas exchange and climate we will gain powerful global insight into future scenarios of continental carbon and water fluxes. This global perspective is essential for Australia to a ....450 Million year history of plant gas exchange capacity and the role of atmospheric carbon dioxide. Our planet faces an increase in atmospheric carbon dioxide that is unprecedented in human history, but has occurred in ancient times. By studying the relationship between past changes in atmospheric carbon dioxide, plant gas exchange and climate we will gain powerful global insight into future scenarios of continental carbon and water fluxes. This global perspective is essential for Australia to assess its vulnerability to global climate change in relation to other nations, thereby informing national planning of landscape resource use, including primary industry, water infrastructure and carbon trading.Read moreRead less
Past and future effects of climate change on the carbon-water balance of plants. Over the coming century, climate change will profoundly impact Australian vegetation via the direct effects of elevated atmospheric carbon dioxide (CO2) on plants and the indirect effects of CO2-forced changes in rainfall and temperature, with major implications for agricultural production and water resources. This project will address these threats by providing new tools for measuring and predicting vegetation-clim ....Past and future effects of climate change on the carbon-water balance of plants. Over the coming century, climate change will profoundly impact Australian vegetation via the direct effects of elevated atmospheric carbon dioxide (CO2) on plants and the indirect effects of CO2-forced changes in rainfall and temperature, with major implications for agricultural production and water resources. This project will address these threats by providing new tools for measuring and predicting vegetation-climate feedbacks. It will determine the combined effects of elevated atmospheric CO2 and drought on the productivity of natural and agricultural landscapes, and provide the biophysical framework for developing the next generation of high-yielding, drought tolerant crop varieties for the rapidly approaching greenhouse world.Read moreRead less