Modafinil For Neurobehavioural Dysfunction In Sleep Apnea Patients Who Cannot Use Standard Device-based Treatments.
Funder
National Health and Medical Research Council
Funding Amount
$505,830.00
Summary
Obstructive sleep apnea (OSA) is often caused by obesity and can result in fall-asleep car crashes. It is often treated by mechanical devices that keep the sleeping airway open. Unfortunately, around half of all patients cannot tolerate these treatments. We propose to help patients reduce obesity with a lifestyle intervention program whilst testing whether their daytime symptoms of sleepiness and poor driving ability can be treated with a wake-promoting drug called modafinil.
Chronotherapy For Hypertension In Obstructive Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$253,229.00
Summary
Obstructive Sleep Apnea (OSA) is a common cause of hypertension, however treatment of OSA only results in a modest improvement in blood pressure (BP) and patients who are unable to tolerate treatment must rely on pharmacotherapy to control their BP. This study will definitively establish if altering the time of taking medication can improve BP control over 24 hours. The results will conribute to the development of more targeted treatment strategies for hypertension in people with OSA.