Identifying Target Genes For Novel Anti-epileptic Therapies In The Mouse
Funder
National Health and Medical Research Council
Funding Amount
$469,802.00
Summary
Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not respo ....Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not responding to current therapy. This project is designed to identify new biologic pathways which may be interrupted with drugs to prevent seizures in people with epilepsy. This project uses a procedure to induce mutations into genes in mice and then screens for mice which do not seize when challenged with a drug which generates seizures in mice. Genetic studies will identify the mutated genes and these will be used as potential targets for new therapies or will identify new biological pathway which should expand the use of future anti-epileptic drugs.Read moreRead less
Reconstructing wheat evolution using ancient DNA. The domestication of wild grasses by farmers was a step change in human history; it led to the emergence of modern cereals and with them, western civilisation. This project will apply modern DNA sequencing methods to 5000-year-old cereal seeds to reconstruct the history of wheat, barley and other crops, and identify lost ancient forms and diversity.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100051
Funder
Australian Research Council
Funding Amount
$755,000.00
Summary
Ultrafast Laser Spectroscopy Facility. The Ultrafast Laser Spectroscopy Facility will provide a comprehensive range of new spectroscopic techniques that cover all energies (from the ultraviolet to infrared regions of the spectrum) and timescales relevant to the absorption, emission and transformation of light in advanced photo-active materials. Expected outcomes and benefits are more efficient light harvesting, lighting and optical sensing processes; control over light-induced activity in new m ....Ultrafast Laser Spectroscopy Facility. The Ultrafast Laser Spectroscopy Facility will provide a comprehensive range of new spectroscopic techniques that cover all energies (from the ultraviolet to infrared regions of the spectrum) and timescales relevant to the absorption, emission and transformation of light in advanced photo-active materials. Expected outcomes and benefits are more efficient light harvesting, lighting and optical sensing processes; control over light-induced activity in new materials, and enhanced chemical reactivity. This will provide a platform to enhance capacity in materials characterisation, and will increase institutional and cross-disciplinary collaborations involving Universities, defence organisations and industry.Read moreRead less
Stabilisation of Titania Pigment Slurries During Processing. This project aims to improve the stabilisation properties of titania pigment slurries during production. Current polyphosphate dispersants used by Tiwest are unstable under processing conditions. Tailored, robust dispersing reagents will therefore be investigated in order to provide improved stabilisation of pigments during processing. Enhanced understanding of the dispersing reagents interaction with the titania pigment surface and th ....Stabilisation of Titania Pigment Slurries During Processing. This project aims to improve the stabilisation properties of titania pigment slurries during production. Current polyphosphate dispersants used by Tiwest are unstable under processing conditions. Tailored, robust dispersing reagents will therefore be investigated in order to provide improved stabilisation of pigments during processing. Enhanced understanding of the dispersing reagents interaction with the titania pigment surface and the subsequent stability of the pigment will allow advances in processing and consequently improved final products. The potential growth in market share, by improved product performance, is in excess of $50M pa.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453743
Funder
Australian Research Council
Funding Amount
$237,654.00
Summary
Advanced Materials Laser Characterisation Facility. A networked laser facility spanning the University of Melbourne, Monash University, the University of Adelaide, and Flinders University, will be created by integrating new laser instrumentation with existing specialised infrastructure. The facility will provide chemists at the four institutions with the necessary equipment to collaboratively investigate and optimise the properties of a diverse array of advanced materials, including nanoparticle ....Advanced Materials Laser Characterisation Facility. A networked laser facility spanning the University of Melbourne, Monash University, the University of Adelaide, and Flinders University, will be created by integrating new laser instrumentation with existing specialised infrastructure. The facility will provide chemists at the four institutions with the necessary equipment to collaboratively investigate and optimise the properties of a diverse array of advanced materials, including nanoparticles, polymers, biomaterials, and artificial photosynthetic systems. The outcome will be a world-class research network, outfitted with a suite of sophisticated techniques that are not currently available at any single university, or through any other Australian institution or consortium.Read moreRead less
A new angle on the coalescence of drops. Many processes depend on what happens when drops and/or bubbles collide with each other, or with the surfaces of other materials. Examples include inkjet printing, agricultural spraying, spray coating of paints, pharmaceutical formulation, stability of cosmetics and foodstuffs, formation of froths and foams, and flow of bubbly liquids. To control these processes, we need to understand how and why drops sometimes do and sometimes do not coalesce with each ....A new angle on the coalescence of drops. Many processes depend on what happens when drops and/or bubbles collide with each other, or with the surfaces of other materials. Examples include inkjet printing, agricultural spraying, spray coating of paints, pharmaceutical formulation, stability of cosmetics and foodstuffs, formation of froths and foams, and flow of bubbly liquids. To control these processes, we need to understand how and why drops sometimes do and sometimes do not coalesce with each other or adhere to surfaces. The knowledge gained in this project will enable improvements to be made in the efficiency of processes such as those listed above.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346515
Funder
Australian Research Council
Funding Amount
$507,000.00
Summary
Fluorescence Detector for the Australian National Beamline Facility. X-ray absorption spectroscopy (XAS) is an extremely important synchrotron radiation tool for determining the local structure around an X-ray absorbing atom. This has many applications in the study of materials, minerals, metal complexes, and metalloproteins and can often be used to obtain information that is not available by other techniques, because structural information can be obtained in the solid or solution state and in ....Fluorescence Detector for the Australian National Beamline Facility. X-ray absorption spectroscopy (XAS) is an extremely important synchrotron radiation tool for determining the local structure around an X-ray absorbing atom. This has many applications in the study of materials, minerals, metal complexes, and metalloproteins and can often be used to obtain information that is not available by other techniques, because structural information can be obtained in the solid or solution state and in mixtures. The current proposal is aimed at introducing new technology into the Australian National Beamline Facility that will greatly improve the quality and quantity of experiments that can be performed and extend studies into dilute solutions and protein samples.Read moreRead less