Novel Fermion Actions for Lattice Gauge Theory. The Standard Model of the universe is founded on quantum field theories in which gauge bosons mediate the forces between fermions, the constituents of matter. For example, the gluon of Quantum Chromodynamics (QCD) mediates the strong interactions between quarks as they compose protons, and neutrons. The only way to reveal the long-distance properties of this fundamental gauge theory from first principles is to numerically simulate the theory on a s ....Novel Fermion Actions for Lattice Gauge Theory. The Standard Model of the universe is founded on quantum field theories in which gauge bosons mediate the forces between fermions, the constituents of matter. For example, the gluon of Quantum Chromodynamics (QCD) mediates the strong interactions between quarks as they compose protons, and neutrons. The only way to reveal the long-distance properties of this fundamental gauge theory from first principles is to numerically simulate the theory on a space-time lattice. Simulating fermions on a lattice has proved very challenging. This project will explore novel and innovative improved fermion algorithms for the general problem of gauge theories on the lattice.Read moreRead less
The Essence of QCD Vacuum Structure. This first-principles study of quantum field theory will elucidate an outstanding mystery of modern particle physics. Understanding confinement is recognized as one of the top 10 Physics Questions to Ponder for a Millennium or Two. In support of the National Research Priorities, new scientific data visualization techniques will be transferred to industry, facilitating smart information use. Further economic benefits are realized through the training and devel ....The Essence of QCD Vacuum Structure. This first-principles study of quantum field theory will elucidate an outstanding mystery of modern particle physics. Understanding confinement is recognized as one of the top 10 Physics Questions to Ponder for a Millennium or Two. In support of the National Research Priorities, new scientific data visualization techniques will be transferred to industry, facilitating smart information use. Further economic benefits are realized through the training and development of expertise in high-performance parallel computing, promoting an innovation culture and economy. The opportunity for young Australian Honours and Postgraduate students to work at the forefront of nuclear and particle theory is an obvious social benefit.
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The basis of recognition and disposal of dysfunctional proteins by clusterin. When proteins become damaged they can precipitate. A blood protein called clusterin prevents precipitation of damaged proteins. Clusterin does this by forming complexes with the damaged proteins. Clusterin is the first blood protein known to do this. We will discover which parts of clusterin are responsible for this activity. We will also discover whether cells can take up and dispose of the complexes of clusterin and ....The basis of recognition and disposal of dysfunctional proteins by clusterin. When proteins become damaged they can precipitate. A blood protein called clusterin prevents precipitation of damaged proteins. Clusterin does this by forming complexes with the damaged proteins. Clusterin is the first blood protein known to do this. We will discover which parts of clusterin are responsible for this activity. We will also discover whether cells can take up and dispose of the complexes of clusterin and damaged proteins. This work is important because some diseases (eg, Alzheimers disease) involve the toxic effects of abnormal protein precipitation. Understanding how clusterin works may help in developing better treatments for these diseases.Read moreRead less
ARC Centre of Excellence - In Plant Energy Biology (CPEB). Plant cell metabolism underlies the synthesis of important products in crops, and subtle changes in metabolism can enhance germination rates, early seedling vigour, biomass/yield, and tolerance to harsh environments. Research in CPEB will focus on control of this metabolism. Its expertise will enhance Australia's participation in major international research efforts directly relevant to sustainable agriculture in a country with fragile/ ....ARC Centre of Excellence - In Plant Energy Biology (CPEB). Plant cell metabolism underlies the synthesis of important products in crops, and subtle changes in metabolism can enhance germination rates, early seedling vigour, biomass/yield, and tolerance to harsh environments. Research in CPEB will focus on control of this metabolism. Its expertise will enhance Australia's participation in major international research efforts directly relevant to sustainable agriculture in a country with fragile/degrading ecosystems. The research will provide new approaches for enhancing quality metabolite traits important for human health. It will further strengthen our international leadership in plant energy science, and will strengthen Australia's research training in systems biology to influence plant function.Read moreRead less