Investigating The Link Between Oxidative Stress And Biomechanical Integrin Activation In Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$653,742.00
Summary
Diabetes represents a serious healthcare problem globally. A large proportion of deaths associated with diabetes can be attributed to the development of blood clots in the circulation of the heart and brain (heart attack/stroke). The blood clotting mechanism is ‘hyperactive’ in diabetes, although the reason for this is not well defined. In this proposal we will investigate a new mechanism promoting blood clots, and will investigate innovative approaches to reduce this clotting mechanism.
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100531
Funder
Australian Research Council
Funding Amount
$385,000.00
Summary
Milk mimicry: Self-assembly in complex lipid mixtures during digestion. This project aims to decipher the chemical complexity required to mimic the digestive behaviour of milk fats and to identify their influence on lipophilic nutrient activity during transit through the gut. The link between milk's complex fat composition and its nutrient delivery properties are unknown because the digestive colloidal structures that drive fat-soluble nutrient absorption are poorly understood. The project expec ....Milk mimicry: Self-assembly in complex lipid mixtures during digestion. This project aims to decipher the chemical complexity required to mimic the digestive behaviour of milk fats and to identify their influence on lipophilic nutrient activity during transit through the gut. The link between milk's complex fat composition and its nutrient delivery properties are unknown because the digestive colloidal structures that drive fat-soluble nutrient absorption are poorly understood. The project expects to identify which milk lipids are essential to milk’s role as nature’s nutrient delivery vehicle. It will also identify a universally-available nutrient delivery platform for resource-poor communities, and enhanced knowledge of lipid physical chemistry. The findings will promote greater interaction between the dairy and pharmaceutical industries, adding value to their respective products.Read moreRead less