Leveraging Big Data To Assess Medicines Safety In Australia
Funder
National Health and Medical Research Council
Funding Amount
$91,538.00
Summary
The aim of this project is to leverage routinely collected, linked population-level data to generate high calibre evidence on the safety and effectiveness of commonly used prescription medicines in Australia. The results of this work will promote quality use of medicines, reduce medicine-related harms, and directly support medicines policy and decision-making in Australia.
National Database Of Patients With Atrioventicular Septal Defects
Funder
National Health and Medical Research Council
Funding Amount
$45,341.00
Summary
Atrioventricular septal defects are a group of childhood heart diseases affecting all four chambers of the heart and two of the valves. These children do not normally survive past 30 years without surgery. Surgery offers a chance at life, but in the long term up to a quarter of children need further surgery. We are developing an Australian database to determine how best to reduce the risk of these complications, the burden on these children and the cost to society.
Supporting Knowledge Translation In Aboriginal And Torres Strait Islander Primary Health Care: A Developmental Evaluation Of A Stakeholder Engagement Process To Support Use Of Evidence In Systems And Policy Change
Funder
National Health and Medical Research Council
Funding Amount
$66,784.00
Summary
The research uses a developmental evaluation approach and mixed methods to evaluate a dissemination activity that engages stakeholders in Aboriginal and Torres Strait Islander primary health care in using aggregated quality improvement data to identify and address evidence-to-practice gaps in healthcare. Evaluation processes are being used to refine dissemination processes and materials. Findings will also offer insights about using developmental evaluation approaches in knowledge translation.
Post-market Surveillance Of Medicine-related Adverse Events
Funder
National Health and Medical Research Council
Funding Amount
$99,248.00
Summary
Observational studies using administrative data are an important complement to spontaneous reporting systems for detecting medicine-related adverse events after they go to market, as they reflect real-world use of medicines; yet, they require rigorous methodological approaches to avoid bias. This project will review the existing methodologies for detecting adverse events in administrative data and apply them to Australian data.
The Impact Of Maternal Nutrition And Depression On Infant Morbidity, Growth And Development In Vulnerable Populations.
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Malarial infection in pregnant women can lead to serious consequences for the baby including death, low birth weight and bacterial infection. Babies born in the community are more likely to die than babies born in hospital, therefore improving basic medical care for babies at the community level should be an important priority. We aim to evaluate the causes of death and severe illness in newborn infants in Papua New Guinea, and to determine community based strategies to improve these outcomes.
Advancing Physiotherapy Management Of Chronic Pain By Improving Implementation Of Evidence-based Practice
Funder
National Health and Medical Research Council
Funding Amount
$115,883.00
Summary
Chronic musculoskeletal pain is major and concerning public health burden and physiotherapists provide a vital and influential role in managing this problem. High level research has demonstrated effective approaches to managing chronic pain yet there appears to be barriers to implementing such strategies clinically. This project aims to explore these barriers with physiotherapists, devise an intervention to overcome them, and test the feasibility and acceptability of the intervention.
Improving Cardiac Rehabilitation In Victoria, Australia
Funder
National Health and Medical Research Council
Funding Amount
$107,204.00
Summary
This PhD project will identify the key mechanisms for successful scale-up and sustainability of a community based diabetes prevention program - the Kerala Diabetes Prevention Program (NHMRC Project ID 1005324). Based in India where diabetes is becoming increasingly common, these findings have global relevance. Findings will add to crucial evidence gaps in how to systematically scale-up effective prevention programs in order to maximise public health impact.
Polypharmacy In The Heart Failure Patient: Are All Prescribed Drug Classes Required?
Funder
National Health and Medical Research Council
Funding Amount
$134,110.00
Summary
This project investigates the issue of polypharmacy is heart failure. Polypharmacy is the use of four or more prescription medications, and heart failure patients take six on average. This project investigates the evidence for safe withdrawal of medications failure that have not been shown to prolong life in heart, doctor and patient attitudes to withdrawing medications, and then runs a series of three clinical trials, each withdrawing a different medication in heart failure patients and closely ....This project investigates the issue of polypharmacy is heart failure. Polypharmacy is the use of four or more prescription medications, and heart failure patients take six on average. This project investigates the evidence for safe withdrawal of medications failure that have not been shown to prolong life in heart, doctor and patient attitudes to withdrawing medications, and then runs a series of three clinical trials, each withdrawing a different medication in heart failure patients and closely monitors the effects.Read moreRead less
A Prospective Study Of The Aetiology, Associations, Clinical Features And Outcomes Of Community-acquired Pneumonia In Children And Adults In Tropical Australia
Funder
National Health and Medical Research Council
Funding Amount
$106,937.00
Summary
Pneumonia is common in Australia and often requires hospital admission. The germs that cause pneumonia in tropical Australia are less well known than southern Australia and likely to be different. This study will identify which germs cause pneumonia in people in tropical Australia and will identify which people become more unwell. I aim to identify the best antibiotics to use, the differences between children and adults, Indigenous and non-Indigenous people and people living in different areas.
Patients with a first seizure (FS) presenting to EDs receive widely varied and often non-evidenced based care. This can result in future hospital admissions for seizures, injuries, and deaths. Researchers will undertake a literature review and analysis of current management of FS patients. It will be determined if delayed assessments are associated with poorer outcomes and higher treatment costs. We will create a tool to help predict chance of seizure recurrence following a FS.