Physiology of tau protein: a novel role in scaffolding and intracellular distribution. Understanding brain function remains a challenge. This project will study the normal role of the Alzheimer's disease-related protein tau in brain function during ageing. This will significantly enhance current understanding of brain function.
Imagining university education: the perspectives of young people impacted by low socio-economic status and disengagement from school. Significant effort is being made in Australia to increase the participation of students from low socio-economic status backgrounds in university education. This project will contribute to this effort by delivering knowledge on the perceptions of university education held by low socio-economic status young people aged 12-15 disengaged from school.
Mentoring and Indigenous Higher Education: Understanding how university students mentor Indigenous school students. Mentoring Indigenous school students by university students is an expanding initiative to address the education gap experienced by Aboriginal and Torres Strait Islander peoples. This project will investigate what works in successful mentoring between university students and young Indigenous Australians and what are 'mentoring best practices' with Indigenous young people. The projec ....Mentoring and Indigenous Higher Education: Understanding how university students mentor Indigenous school students. Mentoring Indigenous school students by university students is an expanding initiative to address the education gap experienced by Aboriginal and Torres Strait Islander peoples. This project will investigate what works in successful mentoring between university students and young Indigenous Australians and what are 'mentoring best practices' with Indigenous young people. The project builds on our research with the Australian Indigenous Mentoring Experience (AIME), a program engaging university students and Indigenous young people across Australia. Expected outcomes are new knowledge on university student mentoring of Indigenous school children and the design of 'remote' university student mentoring using communication technology.Read moreRead less
Cellular mechanisms that protect against copper-bound beta-amyloid. This project will investigate some of the brain’s own mechanisms for protecting itself against Alzheimer’s disease. Understanding these mechanisms will be important for developing future therapeutic strategies for treating Alzheimer’s disease.
Growth of Bioartificial Tissue Containing an Inbuilt Blood Supply. The large and growing demand for replacement tissues and organs has spurred rapid growth in the emerging field of tissue engineering, which aims to form new tissues in the laboratory by combining living cells and synthetic scaffolds. A major challenge lies in the production of thick tissues, which require a blood supply in order to survive. Uniquely, this project aims to grow in the laboratory a vascular system based on natural ....Growth of Bioartificial Tissue Containing an Inbuilt Blood Supply. The large and growing demand for replacement tissues and organs has spurred rapid growth in the emerging field of tissue engineering, which aims to form new tissues in the laboratory by combining living cells and synthetic scaffolds. A major challenge lies in the production of thick tissues, which require a blood supply in order to survive. Uniquely, this project aims to grow in the laboratory a vascular system based on natural structures, which can then be used to support new tissue growth. Australia is well placed to reap the rewards of this work, having a track record in commercialisation of medical technologies, resulting in an improved quality of life for many Australians and substantial direct and indirect economic benefits.Read moreRead less
Drought-induced mortality in arid-zone tree species: a mechanistic study. This project aims to determine the relative importance of elevated temperature and increased vapour pressure deficit during drought in causing drought induced mortality (DIM). The outcomes of this project will be an enhanced ability to predict future mortality in response to a warmer and atmospherically drier climate. This will benefit the development of future management strategies and our ability to predict drought impac ....Drought-induced mortality in arid-zone tree species: a mechanistic study. This project aims to determine the relative importance of elevated temperature and increased vapour pressure deficit during drought in causing drought induced mortality (DIM). The outcomes of this project will be an enhanced ability to predict future mortality in response to a warmer and atmospherically drier climate. This will benefit the development of future management strategies and our ability to predict drought impacts on landscape function and productivity.Read moreRead less
Socio-economic determinants and health inequalities over the life course: Australian and English comparisons. Our multidisciplinary investigation will yield Australia's first major body of knowledge on the socio-economic determinants of health and health inequalities over the life course. It will point the way towards policies that can promote health and reduce the health inequalities experienced by disadvantaged individuals and families. It will indicate how improving the health of ageing Aus ....Socio-economic determinants and health inequalities over the life course: Australian and English comparisons. Our multidisciplinary investigation will yield Australia's first major body of knowledge on the socio-economic determinants of health and health inequalities over the life course. It will point the way towards policies that can promote health and reduce the health inequalities experienced by disadvantaged individuals and families. It will indicate how improving the health of ageing Australian men and women can increase productivity and reduce needs for health services during the rapid population ageing that lies ahead. Comparisons with England will inform policy choices. We will train researchers who will play a future role in building Australia's evidence base to guide constructive policies to 2020 and beyond.Read moreRead less
An epigenetic basis for foetal programming. The social and economic impact of adult-onset diseases such as diabetes, hypertension and atherosclerosis is increasing. Evidence indicates that a mother's nutrition influences the risk of her children developing some diseases later in life. This proposal aims to elucidate the mechanism underlying this phenomenon. By understanding the mechanism through which maternal nutrition affects disease risk, we may make it possible to design early diagnosis and ....An epigenetic basis for foetal programming. The social and economic impact of adult-onset diseases such as diabetes, hypertension and atherosclerosis is increasing. Evidence indicates that a mother's nutrition influences the risk of her children developing some diseases later in life. This proposal aims to elucidate the mechanism underlying this phenomenon. By understanding the mechanism through which maternal nutrition affects disease risk, we may make it possible to design early diagnosis and intervention strategies. Our work may suggest intervention strategies - such as supplementation of at-risk mothers with key molecules such as methyl donors - during foetal and early postnatal life, which could be key to preventing premature morbidity and mortality.Read moreRead less
Making Australia internationally competitive: driving educational attainment by academic motivation, self-concept, engagement and aspirations. This project will extend and test predictions from motivation theory about educational choice and attainment, using multiple large national/international databases and new statistical models. This will result in better strategies to meet government targets of increasing tertiary enrolments, particularly for disadvantaged students.
Women Consider Retirement: A Critical Investigation of Attitudes Towards Work, Ageing and Retirement in Three Generations of Australian Women. The broad aim of this project is to investigate what work and retirement mean for women as they age and to consider the implications of these attitudes, intentions and experiences for government policy, especially given current concerns about workforce maintenance in view of population ageing.
The project will:
- develop a comprehensive understanding ....Women Consider Retirement: A Critical Investigation of Attitudes Towards Work, Ageing and Retirement in Three Generations of Australian Women. The broad aim of this project is to investigate what work and retirement mean for women as they age and to consider the implications of these attitudes, intentions and experiences for government policy, especially given current concerns about workforce maintenance in view of population ageing.
The project will:
- develop a comprehensive understanding of the characteristics, attitudes and experiences of three generations of women in relation to work, ageing and retirement
- examine the extent and consequences of generational and geographic differences in attitudes and choices
- explore the complex social and cultural factors shaping these attitudes, choices and consequences.
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