The neurocognitive basis of dual-task co-ordination impairment in Alzheimer’s: defective coordination mechanism or differences in speed of processing? This project explores the effects of age, depression and Alzheimer’s disease on the ability to carry out two tasks at once, to determine whether difficulty doing so is due to slowed mental processing, or to a deficit in a mechanism responsible for task coordination. The project will advance cognitive theory and may help with diagnosis of dementia.
Evolution and the immune system: genetic differences in immune response between human populations due to adaptation to living in different geo-climatic locations. The project, which investigates the genetics of inter-population differences in immune response, will lead to advances in immunology and population genetics research, explain present population specific differences in disease incidence and possibly forecast future population trends of diseases such as asthma and allergy. The study will ....Evolution and the immune system: genetic differences in immune response between human populations due to adaptation to living in different geo-climatic locations. The project, which investigates the genetics of inter-population differences in immune response, will lead to advances in immunology and population genetics research, explain present population specific differences in disease incidence and possibly forecast future population trends of diseases such as asthma and allergy. The study will strengthen ties with collaborators around the world, thus promoting excellence in Australian research and gain Australia prestige in the international community as a country that produces research of global significance. Understanding the immune system's 'recent evolutionary roots' has implications for the health of Australians, especially in light of Australia's increasingly multi-ethnic background.Read moreRead less
Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their inter ....Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their interaction with drugs is essential in order to develop new therapies and to effectively design novel biological compatible bone implants. This research proposal closely aligns with national research priority two, i.e., promoting and maintaining good health (ageing well, ageing productively).Read moreRead less
Dynamic CFD Simulations and Scale-Up of Three-Phase Slurry Reactors for Gas-to-Liquid (GTL) Technology. The gas-liquid-solid flow patterns in three-phase slurry bubble column reactors will be studied using experiments and CFD. The effect of various reactor parameters will be studied to develop the scale-up heuristic for the slurry bubble column reactor. The Findings of this study will be used to optimise the reactor system for the offshore natural gas locations of Australia. A successful impleme ....Dynamic CFD Simulations and Scale-Up of Three-Phase Slurry Reactors for Gas-to-Liquid (GTL) Technology. The gas-liquid-solid flow patterns in three-phase slurry bubble column reactors will be studied using experiments and CFD. The effect of various reactor parameters will be studied to develop the scale-up heuristic for the slurry bubble column reactor. The Findings of this study will be used to optimise the reactor system for the offshore natural gas locations of Australia. A successful implementation of this project will bring a huge economic benefit to Australia by utilising the vast amount of remotely located and otherwise unusable stranded natural gas reserves. The project falls within one of National Research Priorities: An Environmentally Sustainable Australia.Read moreRead less
Developing a disability policy model to target the prevention or reduction of limitations on functioning and wellbeing. With the ageing of Australian society the challenge for public health is shifting from preventing death and disease onset to supporting healthy and productive ageing. The disability policy model will allow cost-effective targeting of interventions to reduce or prevent onset of disability or reduce its severity particularly among older Australians.
The feasibility, acceptability and cost-effectiveness of nurse-led models of chronic disease management in general practice. This study directly relates to the National Research Priority of 'promoting and maintaining good health' through our approach to trial a new and innovative model of chronic disease management specifically for CVD and Type II diabetes in general practice. This project aims to test a new model of health service delivery - that is, the use of a practice nurse to provide chro ....The feasibility, acceptability and cost-effectiveness of nurse-led models of chronic disease management in general practice. This study directly relates to the National Research Priority of 'promoting and maintaining good health' through our approach to trial a new and innovative model of chronic disease management specifically for CVD and Type II diabetes in general practice. This project aims to test a new model of health service delivery - that is, the use of a practice nurse to provide chronic disease care rather than a general practitioner. Our strategy involves collaboration with health providers, stakeholders and consumers to help achieve this by providing patient education and disease management through a registered nurse in general practice.Read moreRead less
I sense, therefore I help: Towards homes that sense and support the aged and infirm. The overall goal is to produce technologies that will enable the home to be a ?intelligent, caring advisor? and provide operational effectiveness for people with decreasing functional capacity (eg aged). It can monitor and support activities of varying complexity without compromising a normal lifestyle, enabling people of varying abilities to be independent, whilst being cared for by their homes. This caring wi ....I sense, therefore I help: Towards homes that sense and support the aged and infirm. The overall goal is to produce technologies that will enable the home to be a ?intelligent, caring advisor? and provide operational effectiveness for people with decreasing functional capacity (eg aged). It can monitor and support activities of varying complexity without compromising a normal lifestyle, enabling people of varying abilities to be independent, whilst being cared for by their homes. This caring will range from advice systems for detecting hazardous situations and alerting the user, through to detecting subtle deviations from complex, normal activities over significant periods of time (such as caused by the onset of an illness).Read moreRead less
Design and Analysis of Optimal Algorithms for Automated Perimetry. Australian demographic studies reveal that visual impairment contributes significantly to disability in the elderly. Glaucoma, the second leading cause of blindness in developed nations, may be slowed if detected early, however recent studies estimate 50% of Australians with glaucoma are undiagnosed. Automated perimetry is used to detect and track such vision loss, but perimetry algorithms perform poorly. This project will design ....Design and Analysis of Optimal Algorithms for Automated Perimetry. Australian demographic studies reveal that visual impairment contributes significantly to disability in the elderly. Glaucoma, the second leading cause of blindness in developed nations, may be slowed if detected early, however recent studies estimate 50% of Australians with glaucoma are undiagnosed. Automated perimetry is used to detect and track such vision loss, but perimetry algorithms perform poorly. This project will design and analyse new algorithms with superior accuracy and efficiency, improving detection and monitoring of vision loss. Enhanced tools for community vision screening will also result, crucial for the ARC's priority goals of ?ageing well, ageing productively? and ?preventative healthcare?Read moreRead less
Characterisation of deficits in driving performance and self-regulation practices among older drivers with bilateral cataract. Despite the high prevalence of cataract among the older population, there is limited evidence on the impact of first and second eye cataract surgery on driving outcomes. This prospective study will use naturalistic in-vehicle driver monitoring devices and a state-of–the-art driving simulator to examine the association between clinical measures of vision, refractive manag ....Characterisation of deficits in driving performance and self-regulation practices among older drivers with bilateral cataract. Despite the high prevalence of cataract among the older population, there is limited evidence on the impact of first and second eye cataract surgery on driving outcomes. This prospective study will use naturalistic in-vehicle driver monitoring devices and a state-of–the-art driving simulator to examine the association between clinical measures of vision, refractive management, driving patterns, self-regulation and driving performance for bilateral cataract patients before first eye surgery, between surgeries and after second eye surgery. The results will inform Ophthalmology and licensing authorities regarding surgical and refractive management as well as fitness to drive assessments for older drivers with bilateral cataract.Read moreRead less
The impact of first and second eye cataract surgery on falls and utilisation of mental health services among older Australians. This population-based study will investigate the association and timing of cataract surgery and health-related costs in reducing the incidence of falls and utilisation of mental health services following first and second eye cataract surgery. Evidence-based recommendations will be developed to improve safety for older Australians.