How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharma ....How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharmaceutical intervention to delay the development of this debilitating disease. A 5 year delay would significantly reduce the number of people with AD, not only adding years of improved quality of life, but also saving hundreds of millions of Australian dollars in health costs.Read moreRead less
Criminalisation of poverty and homelessness in Australia: A national study. The project aims to assess the policing and enforcement of public order crimes and related offences (e.g. obstruct/disobey police, breach of bail, and minor property offences) on individuals experiencing poverty and homelessness. The project endeavours to collect and analyse qualitative data from across Australia on the lived experience of people who are homeless or at risk of homelessness, regarding the impact of crimin ....Criminalisation of poverty and homelessness in Australia: A national study. The project aims to assess the policing and enforcement of public order crimes and related offences (e.g. obstruct/disobey police, breach of bail, and minor property offences) on individuals experiencing poverty and homelessness. The project endeavours to collect and analyse qualitative data from across Australia on the lived experience of people who are homeless or at risk of homelessness, regarding the impact of criminal laws and police powers concerned with presence in, and movement around public places. It will particularly focus on the impact on women, children and Indigenous peoples. The outcomes will seek to reduce the criminalisation of homeless people, by identifying law and policy reform options, and comparing their cost with that of 'business as usual'.Read moreRead less
Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent ....Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent widespread complications associated with pain for all hospitalised patients, irrespective of diagnosis or reason for admission. It is also envisaged that this project will establish a model of change that could be used to facilitate evidence-based practice in other aspects of healthcare apart from pain.Read moreRead less
Designing a Holistic Model of Advice to Improve Retirement Planning. We aim to improve retirement planning through the design and application of a new model integrating financial advice with career and health planning to optimise financial and psychological outcomes. We will test a multidisciplinary, holistic model of advice combining specialist knowledge in careers, health, and finances. Expected outcomes of the project include evaluating the use of a broader range of experts during retirement ....Designing a Holistic Model of Advice to Improve Retirement Planning. We aim to improve retirement planning through the design and application of a new model integrating financial advice with career and health planning to optimise financial and psychological outcomes. We will test a multidisciplinary, holistic model of advice combining specialist knowledge in careers, health, and finances. Expected outcomes of the project include evaluating the use of a broader range of experts during retirement planning and developing a model for the future training and development of financial advisers.By optimising the timing of workplace exit, we aim to decrease reliance on pensions and encourage earlier and on-going engagement in the retirement planning process. This will provide significant social and economic benefits.Read moreRead less
Aboriginal and non-Aboriginal sex-offenders in Australia: Assessing risk for practice and policy. A key priority of Australian governments is to improve community safety through reducing the risk of sex offenders re-offending after release from prison. This project will assess the validity of tools used to predict the risk of sexual offender recidivism and identify alternate risk assessment tools for Indigenous and non-Indigenous sex offenders.
Development of a Novel One Step Process for Gas Conversion to Liquid. Australia has a rich natural gas reserve, most of which is in remote locations. This project will lead to a new technology to use the remote gas that would be flared into the atmosphere, thus benefiting both Australian economy and green house gas reduction. It will also reduce the risk of relying on importing oil from Overseas thus contributing to Australia's energy security. In addition, while crude-based oil emits SOx, NOx a ....Development of a Novel One Step Process for Gas Conversion to Liquid. Australia has a rich natural gas reserve, most of which is in remote locations. This project will lead to a new technology to use the remote gas that would be flared into the atmosphere, thus benefiting both Australian economy and green house gas reduction. It will also reduce the risk of relying on importing oil from Overseas thus contributing to Australia's energy security. In addition, while crude-based oil emits SOx, NOx and particulates etc into air, the liquid fuels from gas are pure and burns cleanly thus also contributing to air pollution control. Read moreRead less
Investigating older Australians' beliefs about and understanding of mental health and their practice of relevant protective behaviours. Healthy ageing and mental health are acknowledged national priorities. This project will generate new knowledge relating to older Australians' mental health literacy and the motivators and barriers influencing their engagement in protective behaviours. The resulting communications strategy will provide tangible outcomes for the industry partners to utilise. The ....Investigating older Australians' beliefs about and understanding of mental health and their practice of relevant protective behaviours. Healthy ageing and mental health are acknowledged national priorities. This project will generate new knowledge relating to older Australians' mental health literacy and the motivators and barriers influencing their engagement in protective behaviours. The resulting communications strategy will provide tangible outcomes for the industry partners to utilise. The project will thus produce knowledge advancement and tools for practitioners, both of which will enhance public welfare and reduce long-term healthcare costs. While this project focuses on older Australians, those of all ages will benefit from a communications campaign that provides individuals with knowledge to protect and strengthen their mental health.Read moreRead less
Fundamental Data and Thermodynamic Modelling for Cryogenic LNG Fluids to Improve Process Design, Simulation and Operation. This research will contribute to a more environmentally sustainable Australia because it will promote the use of natural gas as a fuel supply which produces significantly fewer greenhouse gases than oil or coal. This project will improve the ability of engineers to reliably simulate LNG production plants as well as test new processes and technologies with the potential to in ....Fundamental Data and Thermodynamic Modelling for Cryogenic LNG Fluids to Improve Process Design, Simulation and Operation. This research will contribute to a more environmentally sustainable Australia because it will promote the use of natural gas as a fuel supply which produces significantly fewer greenhouse gases than oil or coal. This project will improve the ability of engineers to reliably simulate LNG production plants as well as test new processes and technologies with the potential to increase efficiency or revenue. Consequently, the level of over-engineering and, thus, the capital and operational costs of such plants will decrease. This in turn will promote the development of Australian gas reserves, particularly for those fields currently on the margins of economic viability.Read moreRead less
Unsaturated zone functioning in a semi-arid flash flood driven climate. Groundwater is the only perennial water source in arid and semiarid zones, which encompass 1/3 of the global landmass and 70 % of Australia. We still do not fully understand how the unsaturated zone contributes to groundwater recharge in semi-arid zone floodplains. We will study the dynamics of soil moisture, and its contribution to groundwater recharge respective to hydrological regimes and weather patterns. We will measure ....Unsaturated zone functioning in a semi-arid flash flood driven climate. Groundwater is the only perennial water source in arid and semiarid zones, which encompass 1/3 of the global landmass and 70 % of Australia. We still do not fully understand how the unsaturated zone contributes to groundwater recharge in semi-arid zone floodplains. We will study the dynamics of soil moisture, and its contribution to groundwater recharge respective to hydrological regimes and weather patterns. We will measure direct responses to flood events using loggers and compare them to indirect measurements inferred from hydrochemical and isotope tracer models to better understand recharge patterns, evaporative losses, and interactions between surface runoff, floodplains, and aquifers at different positions in the landscape.Read moreRead less
Do hotter and drier regions harbour adaptive variation for climate change? This project aims to improve our understanding of the capacity of trees to respond to climate change. This is essential for the maintenance of biodiversity, forest health and productivity. In south-west Australia, climate variation has increased the frequency and intensity of droughts, which has resulted in tree death and negatively affected essential ecosystem services. Adaptive land management is urgently needed to miti ....Do hotter and drier regions harbour adaptive variation for climate change? This project aims to improve our understanding of the capacity of trees to respond to climate change. This is essential for the maintenance of biodiversity, forest health and productivity. In south-west Australia, climate variation has increased the frequency and intensity of droughts, which has resulted in tree death and negatively affected essential ecosystem services. Adaptive land management is urgently needed to mitigate the risk of large-scale drought mortality in a rapidly changing climate. This project seeks to deliver a scientific basis for the adoption of assisted gene migration in south-west forests, through a detailed understanding of genetic adaptation and physiological tolerance, to improve drought-resilience under future hotter and drier climates.Read moreRead less