Epigenetics Of Human Placental Development And Pregnancy-associated Disease.
Funder
National Health and Medical Research Council
Funding Amount
$85,526.00
Summary
Mounting evidence suggests that epigenetic changes such as DNA methylation during pregnancy may play an important role in adverse pregnancy outcomes and modulation of disease risk later in life. We have identified a range of distinct DNA methylation events in human placental cells that are likely to play a role in both normal human placentation and aspects of placental dysfunction. We believe that disruption of this epigenetic profile contributes to adverse pregnancy outcomes
Molecular Determinants Of Therapeutic Response In Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$87,646.00
Summary
Colorectal cancer (CRC) is the second most common cause of cancer death. We will examine whether treatments of advanced CRC can be optimized by (1) selection based on the patient's expression of biomarkers (ie. cancer proteins) and-or (2) appropriate combinations of chemotherapy and-or immunotherapy. Using samples from patients we aim to determine predictors of response to a single therapy (bevacizumab) or a novel combination of therapies (erlotonib and cetuximab) to enhance future treatments.
Understanding Parent Behaviours That Promote Language In Slow-to-talk Toddlers
Funder
National Health and Medical Research Council
Funding Amount
$95,144.00
Summary
Research suggests that parent-child interactions can have a positive effect on the language development of preschool age children. This community-based study aims to identify which specific parent behaviours promote language in a group of 200 slow-to-talk toddlers. If specific parent behaviours are found to result in better language outcomes in slow-to-talk toddlers, the results will have the potential to promote far more pro-active management of early language delay.