Prevention Of Asthma In Young Children Via Immunostimulation
Funder
National Health and Medical Research Council
Funding Amount
$679,683.00
Summary
Persistent asthma is a major problem for Australia yet none of the current therapies do more that control the condition. The long-term solution is to prevent asthma from progressing to the persistent form. The major risk factors are: family history, early allergy and recurrent severe lower respiratory infections (sLRI) in the early life. We will conduct a randomized clinical trial to prevent sLRI using a novel bacterial-derived immunostimulant in infants at high risk of developing asthma.
The prevalence of food allergy (FA) has risen dramatically in the last 20 years. Strong evidence suggests that undetermined lifestyle factors are central to this modern phenomenon. We will develop a CRE in Paediatric FA and Food-related Immune Disorders, providing international leadership in public health initiatives to stem the tide of FA and related disorders. We are uniquely placed to provide evidence-based guidelines that will inform public health policy and clinical care of patients.
Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will explo ....Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will exploit two sophisticated new synthetic techniques for the purposes of making analogues of platencin that will be screened by the industry partner, Biota, for anti-bacterial properties. New drug candidates capable of treating especially dangerous infections such as methicillin resistant staphyllococcus aureus (MRSA) should thus emerge.Read moreRead less
Identifying novel, health-related predictors of recidivism: Informing evidence-based throughcare. Throughcare is a policy priority for correctional authorities in Australia, however the evidence base to inform policy is limited. Using innovative modelling techniques and unique data from a large, representative cohort of ex-prisoners in Queensland, this study will: identify novel, health-related predictors of recidivism in the first two years after release from adult custody; examine the extent t ....Identifying novel, health-related predictors of recidivism: Informing evidence-based throughcare. Throughcare is a policy priority for correctional authorities in Australia, however the evidence base to inform policy is limited. Using innovative modelling techniques and unique data from a large, representative cohort of ex-prisoners in Queensland, this study will: identify novel, health-related predictors of recidivism in the first two years after release from adult custody; examine the extent to which risk and protective factors for recidivism vary over time and according to individual characteristics; and, provide evidence-based recommendations to improve throughcare interventions and reduce recidivism.Read moreRead less
Aboriginal and non-Aboriginal sex-offenders in Australia: Assessing risk for practice and policy. A key priority of Australian governments is to improve community safety through reducing the risk of sex offenders re-offending after release from prison. This project will assess the validity of tools used to predict the risk of sexual offender recidivism and identify alternate risk assessment tools for Indigenous and non-Indigenous sex offenders.
Strengthening Australia's national integrity system. Strengthening Australia's national integrity system. This project aims to equip governments and civil society stakeholders with evidence-based options to improve the structure and operations of integrity institutions, by undertaking a second National Integrity System Assessment. Public integrity is vital to social and economic prosperity and the quality of democracy. This project intends to identify new, more effective strategies to prevent co ....Strengthening Australia's national integrity system. Strengthening Australia's national integrity system. This project aims to equip governments and civil society stakeholders with evidence-based options to improve the structure and operations of integrity institutions, by undertaking a second National Integrity System Assessment. Public integrity is vital to social and economic prosperity and the quality of democracy. This project intends to identify new, more effective strategies to prevent corruption and other integrity violations; coordinate the work of integrity institutions; ensure their accountability; and measure the effectiveness of integrity and anti-corruption policy settings. This research is expected to contribute to better evaluation of integrity policies worldwide.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101276
Funder
Australian Research Council
Funding Amount
$326,150.00
Summary
Breaking patterns of violence to prevent family homicide. This project aims to quantify the relationship and interdependencies between risk factors and service utilisation among family homicide victims and offenders. These will be identified from an analysis of criminal justice and Coroners’ data on family homicide using Bayesian networks. This innovative approach will produce a model to predict the probability of a lethal outcome, and enable resources to be targeted for interventions to parties ....Breaking patterns of violence to prevent family homicide. This project aims to quantify the relationship and interdependencies between risk factors and service utilisation among family homicide victims and offenders. These will be identified from an analysis of criminal justice and Coroners’ data on family homicide using Bayesian networks. This innovative approach will produce a model to predict the probability of a lethal outcome, and enable resources to be targeted for interventions to parties identified as high risk prior to escalation that could lead to death. The knowledge from this project will help save the lives of victims, change the life course of offenders and reduce exposure to violence by other family members to break intergenerational patterns of family violence.Read moreRead less
Optimising illicit dark net marketplace interventions. Optimising illicit dark net marketplace interventions. This project aims to develop and test a series of interventions to disrupt identify theft activities, and design an operational risk framework that will aid law enforcement agencies and organisations to timely and appropriately intervene in cyber space. The buying and selling of identity credentials via dark net forums is a significant and growing problem. This research— based on systems ....Optimising illicit dark net marketplace interventions. Optimising illicit dark net marketplace interventions. This project aims to develop and test a series of interventions to disrupt identify theft activities, and design an operational risk framework that will aid law enforcement agencies and organisations to timely and appropriately intervene in cyber space. The buying and selling of identity credentials via dark net forums is a significant and growing problem. This research— based on systems analyses of dark net forums, and bringing together researchers, practitioners, theories and methods from human factors, sociotechnical systems, criminology, and cyber security—is expected to increase understanding of the dark net and improve ways of disrupting identity theft and trading.Read moreRead less
The Burden And Risk Factors Of Depressive Disorders In Indigenous Australians: Implications For Early Detection And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This Fellowship addresses the high rates of depression amongst Indigenous Australians. The proposed work will quantify the extent to which two major risk factors contribute to the burden of depression in this population and the burden avertable from interventions to modify these risk factors. Findings would inform resource allocation and health service delivery, and in doing so, present opportunities for improvements in the health of Indigenous Australians.