Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal w ....Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal will receive international recognition and will encourage more research in this field, attracting international funding, and create new research opportunities. Read moreRead less
Molecular Fingerprinting: Forensic Spectroscopy of Trace Gases. Safeguarding Australia from terrorism, crime and invasive diseases is essential to securing our national infrastructure. This project will develop national capabilities in anticipating and responding to critical threats to society. The scientific instrumentation developed from this effort will enhance Australia's potential aid for early detection of explosive and chemical weaponry and also in the analysis of crime scenes. This rese ....Molecular Fingerprinting: Forensic Spectroscopy of Trace Gases. Safeguarding Australia from terrorism, crime and invasive diseases is essential to securing our national infrastructure. This project will develop national capabilities in anticipating and responding to critical threats to society. The scientific instrumentation developed from this effort will enhance Australia's potential aid for early detection of explosive and chemical weaponry and also in the analysis of crime scenes. This research will significantly improve our abilities to maintain the operational advantage of Australia's security agencies through superior capabilities in threat detection.Read moreRead less
A Physicochemical Approach for Optimizing Drug Delivery from BioSilicon. By applying modern techniques and a multidisciplinary approach, this research will develop an understanding of drug loading of BioSiliconTM at a molecular level. This novel class of nano-structured biomaterial has exciting potential for developing a range of controllable drug delivery systems. Existing medical applications of BioSilicon deliver only small molecules for very specialised uses. Current research has not focused ....A Physicochemical Approach for Optimizing Drug Delivery from BioSilicon. By applying modern techniques and a multidisciplinary approach, this research will develop an understanding of drug loading of BioSiliconTM at a molecular level. This novel class of nano-structured biomaterial has exciting potential for developing a range of controllable drug delivery systems. Existing medical applications of BioSilicon deliver only small molecules for very specialised uses. Current research has not focused on understanding the pore structure and how it can be adapted for special applications. Our research will create new drug delivery systems with many innovative applications in medical, veterinary and bio-diagnostics fields. The medical and socio-economic impacts will be internationally significant.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775612
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Nanomaterials Optical Characterisation Facility. Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However, the small length scales involved present significant challenges with regard to characterising the nanomaterials produced. The Nanomaterials Optical Characterisation facility will provide state-of-the-art equipment for examining the properties of nanomaterials. The equipment will be pivotal in assisting the de ....Nanomaterials Optical Characterisation Facility. Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However, the small length scales involved present significant challenges with regard to characterising the nanomaterials produced. The Nanomaterials Optical Characterisation facility will provide state-of-the-art equipment for examining the properties of nanomaterials. The equipment will be pivotal in assisting the development of next-generation medicines, implants, optical devices and surface coatings, further strengthening Australia's formidable reputation in these areas.Read moreRead less
Reactivity and Spectroscopy of Gas Phase Metal Oxide Cluster Ions: Structure-Reactivity Correlations and Fundamental Insights into Heterogeneous Catalysis. This project will make use of world class ARC funded instrumentation to carry out breakthrough science. The research will contribute fundamental insights into chemical bond activation relevant to industrial catalytic processes important to national manufacturing industries. These insights will improve the efficiency and selectivity of catal ....Reactivity and Spectroscopy of Gas Phase Metal Oxide Cluster Ions: Structure-Reactivity Correlations and Fundamental Insights into Heterogeneous Catalysis. This project will make use of world class ARC funded instrumentation to carry out breakthrough science. The research will contribute fundamental insights into chemical bond activation relevant to industrial catalytic processes important to national manufacturing industries. These insights will improve the efficiency and selectivity of catalytic processes and lead to increased profitability and/or a reduction in unwanted side products and pollution. The project will train young scientists in important experimental and theoretical chemical techniques, and will enhance and contribute to Australia's international research profile.Read moreRead less
Double Exposure Photoresists for the 32 and 22 nm Lithographic Nodes. The semiconductor industry is one of the largest world-wide, with annual revenue of $220B and employing over 1.5M people around the world. This project provides a unique opportunity for development within Australia of significant expertise in the field of double exposure lithography. The novel photoactive polymeric films to be developed are expected to support the next generation of microchips. A major outcome of this project ....Double Exposure Photoresists for the 32 and 22 nm Lithographic Nodes. The semiconductor industry is one of the largest world-wide, with annual revenue of $220B and employing over 1.5M people around the world. This project provides a unique opportunity for development within Australia of significant expertise in the field of double exposure lithography. The novel photoactive polymeric films to be developed are expected to support the next generation of microchips. A major outcome of this project will be establishment of Australia as a world-leader in this rapidly expanding field. Furthermore the technology can be applied broadly to many printing technologies.Read moreRead less
Advanced Lithographic Solutions using Block Copolymers: Integrating Self Assembly and Lithography. The semiconductor industry is one of the largest world-wide, with annual revenue of $220B and employing over 1.5M people around the world. This project provides a unique opportunity for development within Australia of significant expertise in the field of self assembly in photolithography. Plastics with tailored properties will be made and used to develop novel processes to reduce the defectivity i ....Advanced Lithographic Solutions using Block Copolymers: Integrating Self Assembly and Lithography. The semiconductor industry is one of the largest world-wide, with annual revenue of $220B and employing over 1.5M people around the world. This project provides a unique opportunity for development within Australia of significant expertise in the field of self assembly in photolithography. Plastics with tailored properties will be made and used to develop novel processes to reduce the defectivity in integrated circuit manufacture. The ultimate benefit will be faster and more energy efficient microprocessors. A major outcome of this project will be establishment of Australia as a world-leader in this rapidly expanding field. Furthermore, the technology can be applied broadly to many other applications such as high density data storage.Read moreRead less
The recovery of Cu from chalcopyrite-pyrite containing concentrates, ores and tailings. Chalcopyrite, a major source of Cu, is often associated in ores with the valueless mineral pyrite. The development of more efficient methods for the retrieval of the Cu is of considerable economic importance to Australian minerals processing companies. We aim to develop methodologies allowing the more efficient :
- separation of chalcopyrite and pyrite;
- leaching of Cu from ores and tailing in a heap leach ....The recovery of Cu from chalcopyrite-pyrite containing concentrates, ores and tailings. Chalcopyrite, a major source of Cu, is often associated in ores with the valueless mineral pyrite. The development of more efficient methods for the retrieval of the Cu is of considerable economic importance to Australian minerals processing companies. We aim to develop methodologies allowing the more efficient :
- separation of chalcopyrite and pyrite;
- leaching of Cu from ores and tailing in a heap leach environment and
- leaching of Cu in a concentrated chalcopyrite-pyrite reactor environment.
These aims will be achieved via an integrated surface-solution speciation approach allowing the manipulation of surface properties.
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Controlling density, viscosity and crystallisation in emulsion explosives to enhance safety and efficiency of blasting operations. The performance of emulsion explosives used throughout the mining industry can be severely compromised by the effects of shear arising from pumping and detonation shock waves. Understanding how shear affects droplet coalescence and crystallisation is critical in differential energy blasting, where emulsion density and composition vary widely along the bore hole. This ....Controlling density, viscosity and crystallisation in emulsion explosives to enhance safety and efficiency of blasting operations. The performance of emulsion explosives used throughout the mining industry can be severely compromised by the effects of shear arising from pumping and detonation shock waves. Understanding how shear affects droplet coalescence and crystallisation is critical in differential energy blasting, where emulsion density and composition vary widely along the bore hole. This project aims to contribute to the understanding of the effects of shear, and develop new methods and additives to stabilise droplets and bubbles over a wide range of compositions and conditions. The goal of this project is to improve the efficiency and safety of rock-blasting operations, reduce environmental impact, and reduce operating costs, giving the Australian mining industry a competitive edge.Read moreRead less
Polymers at Mineral Interfaces. Polymers are used widely in the mineral processing industry to alter mineral surfaces, often selectively. In spite of this, there remains a gap in our understanding of how polymers interact with mineral surfaces and how their surface structure affects the mineral surface properties. The aim of this project is to fill this gap by performing fundamental research on adsorbed polymer structure and properties, coupled with applied research on real mineral ores from a ....Polymers at Mineral Interfaces. Polymers are used widely in the mineral processing industry to alter mineral surfaces, often selectively. In spite of this, there remains a gap in our understanding of how polymers interact with mineral surfaces and how their surface structure affects the mineral surface properties. The aim of this project is to fill this gap by performing fundamental research on adsorbed polymer structure and properties, coupled with applied research on real mineral ores from a number of mineral companies. The combination of fundamental and applied research makes this project unique in the study of polymers at mineral interfaces, and will enable us to solve real processing problems through a rational choice of polymers for a given application.Read moreRead less