The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
Understanding The Acute And Cumulative Metabolic Effects Of Prolonged Sitting In Adults
Funder
National Health and Medical Research Council
Funding Amount
$416,597.00
Summary
Sedentary behaviour (sitting time) has been linked to an increased risk of chronic illnesses, including type 2 diabetes and obesity, but recent evidence suggests that light-intensity activity (non-exercise activities of daily living) is associated with reduced risk. These studies will examine whether breaking up sitting time with frequent short periods of activity can overcome the negative effects of prolonged sitting on blood glucose and blood fats in overweight older adults.
Improving Health Outcomes In Atrial Fibrillation Via Optimal Management
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Atrial fibrillation (AF; the most common irregular heart beat seen in medical practice) is becoming increasingly more common, costly and deadly in Australia and worldwide, particularly due to population ageing. The goal of this research is to develop 3 patient assessment tools focussing specifically on AF and improving a patient’s ability to care for themself. Overall, the goal is to make patient care more AF focussed and individual and more likely to result in better long-term health benefits.
About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock a ....About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work. Read moreRead less
CENTRE OF RESEARCH EXCELLENCE TO REDUCE INEQUALITY IN HEART DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$2,607,253.00
Summary
There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health ....There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health care services.Read moreRead less
A Randomised Placebo-controlled Trial Of Antibiotics To Prevent Urinary Tract Infection In Children
Funder
National Health and Medical Research Council
Funding Amount
$735,000.00
Summary
This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this ....This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this means the identification of children thought to be most at risk of recurrent UTI by renal tract imaging. Those found to have reflux of urine from the bladder to the kidney (present in about 30% of those with UTI) are then placed on antibiotics fro 2-5 years. Unfortunately there has never been a properly designed trial to test whether antibiotics do really prevent UTI and if so, whether children with reflux are the appropriate and only group requiring treatment. Long term antibiotics may in fact do more harm than good because of side effects like skin, bowel and blood problems and because resistant bacteria may develop. The design of this study involves the random allocation of placebo or antibiotic (cotrimoxazole, the usual antibiotic given in this case) to about 800 children after their first symptomatic UTI. These children are treated and followed for one year to determine the rate of futher UTI in both groups. Any difference in outcome between the two groups of children will be because of the antibiotic treatment. This study may prove long-term antibiotics are ineffective and therefore should not be routinely used. In this case investigation of children to detect vesicoureteric reflux would serve little purpose and should be abandoned. Alternatively antibiotic treatment may be shown as effective treatment for preventing further UTI and in this case the study will clearly identify those children who will benefit.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100053
Funder
Australian Research Council
Funding Amount
$358,031.00
Summary
A national facility for the analysis of pyrogenic carbon. This project aims to develop a national facility for pyrogenic carbon analysis. Pyrogenic carbon is a poorly constrained, slow-cycling terrestrial carbon pool with significant carbon sequestration potential. The project expects to expand the newly developed hydrogen pyrolysis analytical capability to provide high throughput, robust measurement of the abundance and isotope composition of pyrogenic carbon in soils and sediments. This will p ....A national facility for the analysis of pyrogenic carbon. This project aims to develop a national facility for pyrogenic carbon analysis. Pyrogenic carbon is a poorly constrained, slow-cycling terrestrial carbon pool with significant carbon sequestration potential. The project expects to expand the newly developed hydrogen pyrolysis analytical capability to provide high throughput, robust measurement of the abundance and isotope composition of pyrogenic carbon in soils and sediments. This will provide significant benefit, such as the ability to make significant advances in areas as diverse as geochronology, archaeology, palaeoecology, soil science geomorphology and carbon cycle/sequestration science.Read moreRead less
Dating the aboriginal rock art sequence of the Kimberley in north west Australia. This project aims to develop a robust time scale for the known aboriginal rock art sequence in the Kimberley, Western Australia (WA). The project will use new knowledge of complex processes on sandstone surfaces across the north Kimberley, and an innovative combination of four scientific dating methods developed through our earlier work. The project expects to provide a well-dated sequence for Kimberley rock art ba ....Dating the aboriginal rock art sequence of the Kimberley in north west Australia. This project aims to develop a robust time scale for the known aboriginal rock art sequence in the Kimberley, Western Australia (WA). The project will use new knowledge of complex processes on sandstone surfaces across the north Kimberley, and an innovative combination of four scientific dating methods developed through our earlier work. The project expects to provide a well-dated sequence for Kimberley rock art based on replication of results, confirmation across different methods, and a large interdisciplinary data set. The project will allow rigorous analysis of the relationship between dating results and rock art styles that has not previously been possible, and give new insights into Australia’s deep indigenous heritage. This will have a significant impact for future efforts in rock art conservation, and lay a foundation for cultural tourism, with important benefits for the local economy and health of regional indigenous communities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989062
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Airborne hyper-spectral scanning for advanced monitoring and assessment of vegetation and water properties. The proposed infrastructure will give Australian researchers the most advanced capabilities available world-wide in airborne remote sensing of the environment. By combining hyper-spectral scanning, with full wave-form resolving Light Detection and Ranging (LIDAR), microwave scanning and sythetic aperture RADAR, flown simultaneously on the most cost-efficient and technologically advanced re ....Airborne hyper-spectral scanning for advanced monitoring and assessment of vegetation and water properties. The proposed infrastructure will give Australian researchers the most advanced capabilities available world-wide in airborne remote sensing of the environment. By combining hyper-spectral scanning, with full wave-form resolving Light Detection and Ranging (LIDAR), microwave scanning and sythetic aperture RADAR, flown simultaneously on the most cost-efficient and technologically advanced research aircraft, it will be possible to assess and monitor a wide range of parameters not accessible to airborne methods before.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100027
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Plant Biosecurity. The ARC Training Centre in Plant Biosecurity aims to deliver a solution for Australia’s increasing biosecurity risk through generational change in its workforce coupled with breakthrough technologies. It will launch an innovative training program for future leaders who will build relationships with end users and engage meaningfully with communities for effective implementation strategies. Expected outcomes include a cohort of highly skilled graduates tha ....ARC Training Centre in Plant Biosecurity. The ARC Training Centre in Plant Biosecurity aims to deliver a solution for Australia’s increasing biosecurity risk through generational change in its workforce coupled with breakthrough technologies. It will launch an innovative training program for future leaders who will build relationships with end users and engage meaningfully with communities for effective implementation strategies. Expected outcomes include a cohort of highly skilled graduates that will innovate novel diagnostic technologies, enable data-driven decision platforms and address barriers to biosecurity adoption. This suite of graduates and technologies will transform the plant biosecurity sector to protect Australia’s $5.7 trillion natural and productive ecosystems.Read moreRead less