The Implementation And Evaluation Of Living Evidence In The Management Of Chronic Kidney Disease.
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Chronic kidney disease (CKD) is a growing health problem. Improving outcomes for patients with CKD requires the translation of research into clinical care. However, scientific research that underpins the management of CKD has rapidly increased, and traditional methods to summarise and inform clinical care are out of date. This project will develop, evaluate, and implement a new approach, known as ‘living-evidence’, that translates research evidence in real-time into the management of patients.
The Benefits of Utilising Visual-Spatial Representations of Numbers . The aim of this project is to investigate how visual-spatial representations of numbers enhance practice to promote the use of retrieval-based over counting-based strategies for children learning early arithmetic. About one-third of Australian children stay reliant on counting strategies for basic arithmetic, despite these being associated with lower achievement in mathematics in later years. Expected outcomes of this project ....The Benefits of Utilising Visual-Spatial Representations of Numbers . The aim of this project is to investigate how visual-spatial representations of numbers enhance practice to promote the use of retrieval-based over counting-based strategies for children learning early arithmetic. About one-third of Australian children stay reliant on counting strategies for basic arithmetic, despite these being associated with lower achievement in mathematics in later years. Expected outcomes of this project are new understandings of how problem-answer associations can be strengthened in memory and the development of tools to promote retrieval-based strategies. Potential benefits include children who are better prepared to take on higher-level mathematics in secondary school and, subsequently, more numerate citizens. Read moreRead less
Improving Reproductive Health Through Infectious Diseases Research
Funder
National Health and Medical Research Council
Funding Amount
$1,957,108.00
Summary
Infectious diseases that impact upon reproductive health remain a major problem worldwide. This proposal will examine human papillomavirus infection, the role of the human microbiota in a number of conditions (necrotising enterocolitis, bacterial vaginosis, and human papillomavirus infection), and antibiotic resistance in sexually transmitted infections. The knowledge generated will be used to improve diagnostics.
Early Career Industry Fellowships - Grant ID: IE230100268
Funder
Australian Research Council
Funding Amount
$476,053.00
Summary
Supporting successful educational pathways of First Nations students. The aim of this study is to develop strategies to prevent the steep drop in school attendance rates of First Nation students as they transition from primary to secondary school. The project expects to generate effective culturally embedded support strategies. In partnership with communities, industry partners and schools we propose to consult, codesign and assess the effectiveness of peer-mentoring of primary school students b ....Supporting successful educational pathways of First Nations students. The aim of this study is to develop strategies to prevent the steep drop in school attendance rates of First Nation students as they transition from primary to secondary school. The project expects to generate effective culturally embedded support strategies. In partnership with communities, industry partners and schools we propose to consult, codesign and assess the effectiveness of peer-mentoring of primary school students by those from the same community who have successfully reached senior grades. The outcome is the evaluation of students’ experiences and ongoing attendance and attainments. Significant benefits are for students’ ongoing school engagement and academic success. Cultural and economic benefits are for all Australians.Read moreRead less
Encoding Interactions and Printability into Hairy Colloidal Biomaterials. Printing mixtures of live cells and biomaterials (or 'BioInks') to make bespoke engineered tissues has the potential to enable personalised platforms for therapeutic discovery and organ replacement. Using a novel high throughput approach to materials synthesis, BioInk design and process optimisation, this project aims to discover new biomaterials and printing nozzles to help realise this potential. It will produce new insi ....Encoding Interactions and Printability into Hairy Colloidal Biomaterials. Printing mixtures of live cells and biomaterials (or 'BioInks') to make bespoke engineered tissues has the potential to enable personalised platforms for therapeutic discovery and organ replacement. Using a novel high throughput approach to materials synthesis, BioInk design and process optimisation, this project aims to discover new biomaterials and printing nozzles to help realise this potential. It will produce new insights in colloid science, cell-laden biomaterials design, and BioInk processing. Structure-property-function guides for colloid-based BioInks and quality-assured bioprinting as outcomes represent significant benefits for researchers and industries alike engaged in biofabrication, cell therapy and biotherapeutics.Read moreRead less
Self-reinforced biopolymer composites. This project will pioneer high performance and biodegradable composites using self-reinforced biopolymer composites. Composites can have poor properties due to interfacial issues, and this reduces their performance. By producing a fully self-reinforced (where the fibre and the polymer are the same type of polymer) polymer composites, the project will develop a way to improve properties, increase the use of biobased materials, and improve recyclability and b ....Self-reinforced biopolymer composites. This project will pioneer high performance and biodegradable composites using self-reinforced biopolymer composites. Composites can have poor properties due to interfacial issues, and this reduces their performance. By producing a fully self-reinforced (where the fibre and the polymer are the same type of polymer) polymer composites, the project will develop a way to improve properties, increase the use of biobased materials, and improve recyclability and biodegradability. Outcomes include greater understanding of design of self-reinforced biopolymer composites structure, processing and properties. This will produce opportunities for high performance biobased composite manufacturing and a growing circular plastics economy for Australia.Read moreRead less
Unravelling early self-regulation: A longitudinal study. National data show persistent issues in Australian children's social-emotional vulnerability. Research shows we have had limited success shifting these trajectories through current education and intervention efforts. In short, we understand enough about self-regulation to establish it as a priority target in early childhood, yet not enough to meaningfully alter current trajectories. This project will develop a ‘big picture’ theory of child ....Unravelling early self-regulation: A longitudinal study. National data show persistent issues in Australian children's social-emotional vulnerability. Research shows we have had limited success shifting these trajectories through current education and intervention efforts. In short, we understand enough about self-regulation to establish it as a priority target in early childhood, yet not enough to meaningfully alter current trajectories. This project will develop a ‘big picture’ theory of children’s self-regulation abilities and change, supported by Australia’s first longitudinal study of early self-regulation, from preschool into early primary school (ages 4 to 6). This robust theory of change is expected to better position ongoing education and intervention efforts to succeed.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100663
Funder
Australian Research Council
Funding Amount
$440,850.00
Summary
The Real Price of Health: Experiences of Out-of-Pocket Costs in Australia. This project aims to investigate the experiences and preferences of Australian families and individuals on low, middle, and high incomes in managing the out-of-pocket costs of chronic disease. This project aspires to ensure outcomes that are relevant to the public and patients through involving people living with chronic disease in the research team. The project expects to generate a discrete choice model that describes p ....The Real Price of Health: Experiences of Out-of-Pocket Costs in Australia. This project aims to investigate the experiences and preferences of Australian families and individuals on low, middle, and high incomes in managing the out-of-pocket costs of chronic disease. This project aspires to ensure outcomes that are relevant to the public and patients through involving people living with chronic disease in the research team. The project expects to generate a discrete choice model that describes people with chronic diseases’ preferences, and the trade-offs that they are faced with when deciding how to manage out-of-pocket health costs. The evidence arising from this innovative study will be used to directly inform Australian health policy, leading to wide-ranging health and economic benefits for the whole community.Read moreRead less
Bioplastics in the environment: lifetimes and toxicology. Globally, governments are implementing policies to drive a move to a circular economy. In the process, new materials are being introduced whose potential impacts need to be understood before they are widely used. This project pioneers investigations into the rate and extent of biodegradation of biodegradable plastics in aquatic and soil environments and the associated ecotoxicology of this process. In particular, it aims to quantify the e ....Bioplastics in the environment: lifetimes and toxicology. Globally, governments are implementing policies to drive a move to a circular economy. In the process, new materials are being introduced whose potential impacts need to be understood before they are widely used. This project pioneers investigations into the rate and extent of biodegradation of biodegradable plastics in aquatic and soil environments and the associated ecotoxicology of this process. In particular, it aims to quantify the extent to which the surfaces of these materials accumulate environmental pollutants via adsorption and other mechanisms. The outcomes will include conceptual models of biodegradation across environments, including lifetimes and likely impacts, critical information for framing a sustainable plastics industry.Read moreRead less
Unravelling cell wall polysaccharide biosynthesis in pathogenic zygomycetes. This project aims to define mechanisms that control cell wall composition and stability in Rhizopus oryzae, a zygomycete fungus responsible for life-threatening human infections. The biochemical properties and function of vital enzymes involved in a newly discovered cell wall polysaccharide biosynthetic pathway will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology an ....Unravelling cell wall polysaccharide biosynthesis in pathogenic zygomycetes. This project aims to define mechanisms that control cell wall composition and stability in Rhizopus oryzae, a zygomycete fungus responsible for life-threatening human infections. The biochemical properties and function of vital enzymes involved in a newly discovered cell wall polysaccharide biosynthetic pathway will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology and structural biology. Expected outcomes include new knowledge on the enzymes that synthesise major fucose-based carbohydrates, to guide the future development of novel strategies for antifungal therapies. The data will also be applicable to animal protection from related zygomycete pathogens.
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