Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of new protocols and therapeutic strategies. Our program will focus on brain salvage in the pre-hospital setting and the acute hospital environment. We will use novel approaches to enhance brain recovery and design new implementation strategies to maximise the benefits of these therapeutic advances.
I am a practising hospital neurologist and world leader in the prevention and treatment of stroke. Our research aims to realise exciting new break-throughs for stroke sufferers by testing the effectiveness and safety of new treatments that promise to improve recovery of function of damaged brain and reduce disability after stroke, and to prevent recurrent strokes.
Liquid Biopsy For Personalised Monitoring Of Melanoma Patients
Funder
National Health and Medical Research Council
Funding Amount
$820,888.00
Summary
Despite the success of recent melanoma treatments, therapies are effective long term in only a proportion of patients. Here we will progress preliminary findings in collaboration with biotechnology and pathology companies to develop highly effective companion biomarkers that will aid treatment decisions throughout disease course. Our team will spearhead translation of these markers into the clinic for routine monitoring of melanoma patients.
Improving Stroke Outcomes: Attenuating Progression And Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$9,331,996.00
Summary
Stroke is the second most common cause of death and major cause disability. There are few proven interventions, so we need to introduce new ones. We developed a bench to bedside program to introduce new stroke therapies and its early secondary prevention. Our general goal is to provide evidence for their effectiveness and safety. We will use animal stroke models, markers in the blood to help diagnose and predict stroke outcome and imaging to help select patients for several clinical trials.
An Australasian, Multi-centre, Randomized, Double-blind, Placebo-controlled Trial Of The Efficacy Of Fluoxetine In Improving Functional Recovery After Acute Stroke
Funder
National Health and Medical Research Council
Funding Amount
$2,306,367.00
Summary
Stroke is one of the top three causes of disability. Treatments that improve recovery after stroke are lacking. We reviewed the world literature and found a number of very small studies which, together, suggest that the antidepressant drug, fluoxetine, may improve the recovery in stroke patients. AFFINITY is a large trial in 1600 Australians and New Zealanders with stroke which aims to find out whether taking fluoxetine for 6 months after a stroke improves recovery compared to a placebo.
Temporal Trends In The Incidence, Site And Survival Of Metastatic Breast Cancer In Australia
Funder
National Health and Medical Research Council
Funding Amount
$190,494.00
Summary
There have been major advances in breast cancer treatment over the last decade. This project will use information collected from the NSW cancer registry and hospitals to report on changes in the type and risk of breast cancer spread and survival for women with a new diagnosis of breast cancer before and after new treatments introduced since 2005. This information is essential for doctors to provide women with up-to-date information; and for planning appropriate health services and research.
Missing Voices: Communication Difficulties After Stroke And Traumatic Brain Injury In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$655,310.00
Summary
Acquired communication disorder (ACD) is a common result of stroke and traumatic brain injury (TBI) and has a devastating impact on victims’ everyday lives. Stroke and TBI occur more than twice as frequently in Indigenous as in non-Indigenous populations, but current uptake of communication rehabilitation services is low and long term outcomes for the individuals are unknown. This Australian first study will examine the extent and impact of ACD in urban and rural Indigenous Australians.
Judgment, responsibility, and the life-world: The phenomenological critique of formalism. This project will contribute to building Australia's capacity in the area of phenomenology and connecting Australian researchers into the international network of phenomenology research. More generally the project will contribute to the broader community debate that is currently emerging around issues of the role and limits of knowledge, especially scientific knowledge, but also knowledge as it arises and i ....Judgment, responsibility, and the life-world: The phenomenological critique of formalism. This project will contribute to building Australia's capacity in the area of phenomenology and connecting Australian researchers into the international network of phenomenology research. More generally the project will contribute to the broader community debate that is currently emerging around issues of the role and limits of knowledge, especially scientific knowledge, but also knowledge as it arises and is applied in organisational and social contexts, and the importance of responsibility and judgment even in areas of technical problem-solving and decision-making. In this latter respect, the project is likely to have an impact in more directly applied areas such as policy formation and decision-making across many different areas.Read moreRead less
Gender and the Production of Early Modern French Medicine. This project contributes to a long-term, large-scale research endeavour focused on the interaction of gender and the development of forms of science and technology in history. This project constitutes a significant investigation into the gendering of medical theory and practice. It is an innovative survey of early modern ideas about the production of medical knowledge and practices, about who had the right and authority to determine medi ....Gender and the Production of Early Modern French Medicine. This project contributes to a long-term, large-scale research endeavour focused on the interaction of gender and the development of forms of science and technology in history. This project constitutes a significant investigation into the gendering of medical theory and practice. It is an innovative survey of early modern ideas about the production of medical knowledge and practices, about who had the right and authority to determine medical theory and about how women participated in this framework. The project is expected to result in a major research monograph and a number of key articles.
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