Non-Alzheimer’s Disease Degenerative Dementias: Identifying Prodromal Genetic/familial Phenotypes, Modifying Factors, And Protein Variations Involved In Progression
Funder
National Health and Medical Research Council
Funding Amount
$6,449,246.00
Summary
This proposal will generate new knowledge necessary for advancing the diagnosis of the non-Alzheimer’s disease dementias. We will identify the preclinical forms of frontotemporal dementia and Lewy body dementia using similar methods to those successfully employed to advance diagnosis of Alzheimer’s disease. Importantly, our team has the capacity to translate these protocols into clinical practice and into further advances in biological knowledge that is necessary for future therapeutic targeting
Validating Novel Serum Markers Of Neurodegeneration In Multiple Sclerosis Patients.
Funder
National Health and Medical Research Council
Funding Amount
$516,304.00
Summary
In multiple sclerosis (MS), permanent disability occurs when brain cells known as neurons are damaged following an immune attack. Current treatments reduce the number and severity of immune attacks, but they do not prevent neuron damage or permanent disability in many patients. There is currently no direct way to measure neuron damage in humans, so it is difficult to develop new drugs to prevent it. To address this need, we will trial a new blood test for measuring neuron damage in MS patients.
Assessment Of Functional Impairment In Motor Neurone Disease
Funder
National Health and Medical Research Council
Funding Amount
$235,793.00
Summary
Motor Neurone Disease (MND) is a devastating disease that causes paralysis of muscles in the arms, legs, swallowing and respiration, causing marked disability. This project will investigate how these changes affect everyday abilities in MND, which will bring unique theoretical and practical contributions to date. On a theoretical level, it will contribute to a growing body of knowledge in MND. On a practical level, this project will lead to better care and support for patients and families.