Regulation of cell proliferation and survival by the ubiquitin system. This project aims to investigate how the fundamental processes of cell division and cell death are controlled at the molecular level by protein degradation enzymes (known as ubiquitin ligases), and how these regulate cellular homeostasis. Using interdisciplinary approaches incorporating proteomics, biochemistry, and molecular cell biology, this project seeks to delineate the components of signalling pathways implicated in the ....Regulation of cell proliferation and survival by the ubiquitin system. This project aims to investigate how the fundamental processes of cell division and cell death are controlled at the molecular level by protein degradation enzymes (known as ubiquitin ligases), and how these regulate cellular homeostasis. Using interdisciplinary approaches incorporating proteomics, biochemistry, and molecular cell biology, this project seeks to delineate the components of signalling pathways implicated in the degradation of proteins implicated in cell division and cell death. Expected outcomes include an increased understanding of how proteins are specifically selected for degradation. Protein degradation pathways operate with remarkable selectivity and this work is expected to illuminate the mechanisms of substrate targeting. The biochemical approaches will provide insight and impact in the areas of cell signaling, organelle biology and cell biology.Read moreRead less
Molecules and mechanisms regulating axonal degeneration and regeneration in Caenorhabditis elegans neurons. Understanding the molecular mechanisms underlying nerve degeneration and regeneration is essential to tackle and provide treatment for neurodegenerative diseases and injury of the nervous system. This project aims to discover, using a genetic approach and a simple animal model system, the molecules regulating these crucial biological processes.
Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowle ....Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowledge of previously intractable developmental processes, training of future scientists and development of international collaborations. This should provide enhanced imaging capacity, a higher quality scientific workforce and position Australia at the forefront of developmental biology.
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Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specif ....Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specificity and develop state-of-the-art modelling technologies to improve knowledge of environmental influence on endothelial cell fate and function. This should provide a new framework to modulate the adaptive capacities of endothelial cells and can potentially enable more predictive and targeted drug efficacy and safety testing.Read moreRead less
Making social cohesion ecocentric through Indigenous language and song . This project expects to develop Indigenous language and song in ways that reframe and Indigenise social cohesion, expanding it from a human-centric policy goal to include connections with everything in Country. Designing and implementing an unprecedented and sustained program of Noongar language and song revitalisation in the south of Western Australia across community, schools, and the performing arts, it should advance th ....Making social cohesion ecocentric through Indigenous language and song . This project expects to develop Indigenous language and song in ways that reframe and Indigenise social cohesion, expanding it from a human-centric policy goal to include connections with everything in Country. Designing and implementing an unprecedented and sustained program of Noongar language and song revitalisation in the south of Western Australia across community, schools, and the performing arts, it should advance the potential for Indigenous expressive culture to nourish reciprocal social and ecological relationships that are adaptable to environmental change. Emerging from a hotspot for biodiversity and global warming, it intends to explore how Indigenous creative responses can focus and spur action on pressing global challenges.
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School retention and second chance schooling. This project is concerned with ensuring that students who experience systemic disadvantage are not excluded from the benefits of a formal education. It provides an account and critique of the growth of second chance schooling options catering to such students in both Australia and the UK.
Predicting coastal ecological futures in an era of unprecedented change. This project aims to show how we can predict the future for coastal habitats, fisheries and biodiversity, and validate the reliability of those predictions. Global change means ecosystems are rapidly changing beyond the bounds of historical data, so we can no longer extrapolate past trajectories to predict the future. Reliable predictions are needed to help managers mitigate the risks of future human activities to the envir ....Predicting coastal ecological futures in an era of unprecedented change. This project aims to show how we can predict the future for coastal habitats, fisheries and biodiversity, and validate the reliability of those predictions. Global change means ecosystems are rapidly changing beyond the bounds of historical data, so we can no longer extrapolate past trajectories to predict the future. Reliable predictions are needed to help managers mitigate the risks of future human activities to the environment. Expected outcomes are improved techniques for making predictions that can inform the adaptive management of ecosystems. This is expected to benefit the management of the coastal zone, including fisheries and habitat restoration, which will contribute to enhancing Australia’s valuable ocean economy. Read moreRead less
Studies in cancer control. As life expectancy in Australia (and throughout the world) continues to rise, so will the burden of cancer escalate. Treating cancer after diagnosis is costly, and in many instances, unsuccessful. Preventive strategies promise to reduce the future cancer burden, yet our knowledge in this arena is limited by the lack of credible research as to what works and what does not. This application addresses this gap directly by conducting research into the control of two cancer ....Studies in cancer control. As life expectancy in Australia (and throughout the world) continues to rise, so will the burden of cancer escalate. Treating cancer after diagnosis is costly, and in many instances, unsuccessful. Preventive strategies promise to reduce the future cancer burden, yet our knowledge in this arena is limited by the lack of credible research as to what works and what does not. This application addresses this gap directly by conducting research into the control of two cancers which exact a growing toll in Australia and elsewhere. The work seeks to identify and understand the causal pathways to cancer, and then use this information to devise evidence-based strategies for cancer control.Read moreRead less
Integrating the conservation and ecosystem-service value of Australia's catchments. This project addresses the Priority Goal of Sustainable Use of Biodiversity by explicitly linking the intrinsic value of biodiversity and supporting ecosystems with the services they provide to humanity (e.g. carbon storage and nutrient cycling). It will employ a comprehensive, innovative approach to integrating conservation, market and non-market values of land holdings in Australia's catchments using the concep ....Integrating the conservation and ecosystem-service value of Australia's catchments. This project addresses the Priority Goal of Sustainable Use of Biodiversity by explicitly linking the intrinsic value of biodiversity and supporting ecosystems with the services they provide to humanity (e.g. carbon storage and nutrient cycling). It will employ a comprehensive, innovative approach to integrating conservation, market and non-market values of land holdings in Australia's catchments using the concept of nature's services. Through extensive collaboration among leading scientists and land managers, the project will identify sites of high value requiring special attention, yield important theoretical advancements to how we value ecosystems, and provide practical and easily applied guidelines for land managers. Read moreRead less
Advanced computer simulations of star cluster evolution. The topic of this fellowship is dynamical simulations of star clusters using high-end graphics cards originally developed for the computer gaming industry. The proposed fellowship will thereby enhance Australia's capacity in the exploitation of high-performance computing and will give it a strong position in the new field of graphics card based simulations. The computer cluster built during the fellowship will also be an outstanding enviro ....Advanced computer simulations of star cluster evolution. The topic of this fellowship is dynamical simulations of star clusters using high-end graphics cards originally developed for the computer gaming industry. The proposed fellowship will thereby enhance Australia's capacity in the exploitation of high-performance computing and will give it a strong position in the new field of graphics card based simulations. The computer cluster built during the fellowship will also be an outstanding environment for the training of students. In addition, while Australia has a strong tradition in star cluster astronomy, it has so far not captured a leadership role in the theoretical analysis. The four years of this fellowship will allow it to establish a world-leading position in star cluster simulations.Read moreRead less