Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic ....Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic substances. Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.Read moreRead less
Why do neutrophils swarm? This project aims to combine novel immunology, microscopy and computational approaches to investigate how immune cells called neutrophils cooperate to protect the host against microbes. Neutrophils are rapidly recruited to sites of inflammation and then utilise a type of highly coordinated collective behaviour termed swarming. However, the role of neutrophil swarms in fighting off infection is poorly understood. The project is poised to generate new knowledge on the imp ....Why do neutrophils swarm? This project aims to combine novel immunology, microscopy and computational approaches to investigate how immune cells called neutrophils cooperate to protect the host against microbes. Neutrophils are rapidly recruited to sites of inflammation and then utilise a type of highly coordinated collective behaviour termed swarming. However, the role of neutrophil swarms in fighting off infection is poorly understood. The project is poised to generate new knowledge on the importance of immune cell cooperation by developing in silico models of the immune response. The project will provide benefit through enhanced understanding of fundamental principles of immunity and develop new computational tools to model complex immune function in silico.Read moreRead less