Identification Of Novel Strategies To Mediate Immunity Against Intracellular Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$325,084.00
Summary
The immune system consists of two arms - innate and adaptive. Current vaccine strategies rely mainly on adaptive features of the immune system to mediate immunity against pathogens. Many pathogens have evolved sophisticated strategies to manipulate the adaptive immune system to render it ineffective. This project will investigate microbial detection by the innate immune system, and aims to discover novel, more effective strategies to mediate immunity against intracellular pathogens.
Enhancing Host Defence Against Intracellular Pathogens By Preventing INOS Interaction With A Negative Regulator, SSB-2
Funder
National Health and Medical Research Council
Funding Amount
$448,881.00
Summary
Secretion of nitric oxide (NO) gas by immune cells is a critical defence mechanism for the killing of intracellular pathogens. Production of NO within cells is regulated by the enzyme iNOS. We propose that preventing iNOS from interacting with its natural inhibitor protein (SSB-2) would allow enhanced and prolonged iNOS expression leading to increased NO and increased killing of pathogens such as the mycobacterium tuberculosis and the Leishmania parasite.
Discovery Early Career Researcher Award - Grant ID: DE130100470
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Understanding mechanisms and functions of evolutionary divergence in innate immune genes. Microorganisms constantly challenge the immune systems of all multi-cellular organisms, and host immune genes must be able to co-evolve with microbes in order for a species to propagate. This project will investigate how host immune genes in a species evolve to enable that species to continue.
Why do neutrophils swarm? This project aims to combine novel immunology, microscopy and computational approaches to investigate how immune cells called neutrophils cooperate to protect the host against microbes. Neutrophils are rapidly recruited to sites of inflammation and then utilise a type of highly coordinated collective behaviour termed swarming. However, the role of neutrophil swarms in fighting off infection is poorly understood. The project is poised to generate new knowledge on the imp ....Why do neutrophils swarm? This project aims to combine novel immunology, microscopy and computational approaches to investigate how immune cells called neutrophils cooperate to protect the host against microbes. Neutrophils are rapidly recruited to sites of inflammation and then utilise a type of highly coordinated collective behaviour termed swarming. However, the role of neutrophil swarms in fighting off infection is poorly understood. The project is poised to generate new knowledge on the importance of immune cell cooperation by developing in silico models of the immune response. The project will provide benefit through enhanced understanding of fundamental principles of immunity and develop new computational tools to model complex immune function in silico.Read moreRead less