Modelling Post-traumatic Stress Disorder In Rats: Hypervigilance And Spread Of Fear
Funder
National Health and Medical Research Council
Funding Amount
$353,248.00
Summary
Post-traumatic stress disorder is characterized by hypervigilance and spread of fear across a network of trauma related memories. The consequences of hypervigilance for information processing, and the mechanisms involved in the spread of fear, are unknown. This project uses animal models to identify these consequences and mechanisms, and their substrates in the brain. It examines how a network of trauma related memories can be erased, and thus, how core symptoms of the disorder may be treated.
Light, Sound And Touch Influence The Autonomic Nervous System Via A Non-canonical Pathway
Funder
National Health and Medical Research Council
Funding Amount
$329,666.00
Summary
We examine a recently discovered brain circuit through which visual and acoustic stimuli can interact with the neural systems that control breathing, blood pressure and heart rate. The outcomes of this project will characterise a pathway by which the external environment can interrupt the normal activity of systems vital for health and wellbeing independent of cognition.
Network Biomarkers Of Traumatic Stress Resilience And Sensitivity
Funder
National Health and Medical Research Council
Funding Amount
$647,344.00
Summary
Psychosocial stress is a major risk factor for several of the most debilitating mental illnesses including major depression, bipolar disorder, schizophrenia and post-traumatic stress disorder. By understanding the genomic basis of resilience and adverse response to traumatic stress in humans, we may predict and prevent psychopathology. This international collaborative research will use blood from soldiers exposed to extreme combat experience to identify biomarkers of stress and resilience.
Early Intervention For Posttraumatic Stress Disorder
Funder
National Health and Medical Research Council
Funding Amount
$670,987.00
Summary
Posttraumatic stress disorder is a major mental health problem affecting many Australians. Most people with PTSD do not seek treatment, despite us having effective treatments. This project aims to overcome this barrier to care by testing a new early intervention administered in hospital within days of traumatic injury. The intervention will build on recent advances in memory reconsolidation to achieve markedly better treatment outcomes.
Trauma-focused CBT & Exercise For Chronic Whiplash: Addressing All Aspects Of A Chronic Condition
Funder
National Health and Medical Research Council
Funding Amount
$673,562.00
Summary
Chronic pain following whiplash injury is common and incurs substantial personal and economic costs. There are few effective treatments available. Recent research has shown that many people with chronic whiplash also have symptoms of posttraumatic stress. This study will investigate whether combining an intervention aimed at decreasing posttraumatic stress with exercise will decrease pain and disability in people with chronic whiplash
Phase-Based Treatment For Posttraumatic Stress Disorder In Traumatized Refugees
Funder
National Health and Medical Research Council
Funding Amount
$1,003,340.00
Summary
Refugees report high rates of posttraumatic stress disorder (PTSD). Low response rates to psychological interventions for PTSD in refugees may be explained by their failure to target co-morbid emotion regulation difficulties. In this project, we will test the efficacy of a phase-based intervention that first targets emotion regulation difficulties before implementing trauma-focused therapy to reduce PTSD in refugees. Findings will advance knowledge and inform clinical interventions for refugees.
The Phenomenology And Treatment Of Emotion Dysregulation In Traumatized Refugees
Funder
National Health and Medical Research Council
Funding Amount
$242,631.00
Summary
Refugee mental health is a crucial public health concern in Australia. Difficulty regulating emotions has been strongly linked to psychological disorders after trauma, however no research has studied this in refugees. This research program uses experimental methods to test a model of emotion dysregulation in refugees, and evaluates the impact of a treatment designed to improve emotion regulation and general mental health in refugees.
Randomised Controlled Trial Of An Integrated Cognitive-behavioural Therapy For The Treatment Of Co-occurring Post Traumatic Stress Disorder And Substance Use Disorder In Adolescents
Funder
National Health and Medical Research Council
Funding Amount
$945,647.00
Summary
There is an urgent need to address the hidden epidemic of child and adolescent trauma and prevent the associated psychological and physical health problems that can persist into adulthood. This study, conducted across three States in Australia, will address a significant gap by evaluating a world-first treatment for post traumatic stress disorder (PTSD) and substance use among adolescents. By intervening early, the enduring disability and public health expenditure associated with these condition
Neural And Genetic Predictors Of Response To Exposure Therapy In Posttraumatic Stress Disorder
Funder
National Health and Medical Research Council
Funding Amount
$391,295.00
Summary
This project aims to identify neural and genetic predictors of treatment response in Posttraumatic Stress Disorder (PTSD). Exposure therapy is the most effective treatment for PTSD, but it is resource intensive and expensive and only 40% of patients respond. By identifying predictors of treatment response, this will allow us to identify at-risk patients and provide more intensive treatmentt prior to engaging in exposure therapy.
Intergenerational Transmission Of PTSD Vulnerability: Does PTSD In A Parent Increase The Risk Of Mental Health Disorders In Their Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$742,136.00
Summary
Post Traumatic Stress Disorder (PTSD) occurs after exposure to trauma; more than 1 million Australians suffer from it. By comparing offspring of Vietnam veteran fathers with PTSD with offspring of veteran fathers with no PSTD, this study will test whether there are ripple effects of PTSD in families of Vietnam veterans, whether they are at higher risk of mental health disorders, and whether their mothers can protect them from psychological disorders.