Cognitive Phenotyping And Personalised Treatment For Methamphetamine Addiction
Funder
National Health and Medical Research Council
Funding Amount
$483,402.00
Summary
Prevention and treatment of addiction to stimulants such as methamphetamine is imperative for community health and safety. This fellowship will enable me to apply my expertise in impulsivity and addiction to identify people at risk of increasing methamphetamine use and to develop and evaluate cognitive training therapies that will empower people with methamphetamine related problems to control their drug use. Outcomes include a risk identification and triage tool and three novel therapies.
Translating Neuroscience Into Treatments And Public Health Policies For Addictive Behaviours
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Advances from neuroscience promise to revolutionise our ability to treat and prevent addictive disorders such as gambling, overeating and drug addiction. These developments may also have unexpected clinical consequences, undermine individuals’ belief in their control over their behaviour or increase stigma and discrimination. This project will develop clinical guidelines and public health policy recommendations to ensure that we realise the benefits of neuroscience while minimising social harms.
Extinguishing Fearful And Addictive Brain During Adolescence
Funder
National Health and Medical Research Council
Funding Amount
$428,437.00
Summary
Exposure therapies rely on the decrease in emotions to previous triggers due to the exposure to those triggers without an emotional event in a safe environment. Adolescence marks a period of maturation that is particularly resistant to such therapies, due to the imbalance of different receptors in their prefrontal cortex. We will redress such chemical imbalance by using existing clinically-approved drugs, and facilitate behavioural therapies to treat adolescent anxiety and substance abuse.
The human genome project was a major advance, allowing for molecular foothold towards an understanding of human diseases. The question now is “what do these genes do, and how do they participate in human disease?” In my lab we are focused on this issue. We use whole genome, functional in vivo screening in the fruit fly to identify novel conserved disease genes, then we use human genetics data to focus on medically relevant candidates, finally we use knockout mice to functionally validate these n ....The human genome project was a major advance, allowing for molecular foothold towards an understanding of human diseases. The question now is “what do these genes do, and how do they participate in human disease?” In my lab we are focused on this issue. We use whole genome, functional in vivo screening in the fruit fly to identify novel conserved disease genes, then we use human genetics data to focus on medically relevant candidates, finally we use knockout mice to functionally validate these new genesRead moreRead less
Improving Outcomes In Low Back Pain: Targeting Specific Therapies To Patient Subgroups
Funder
National Health and Medical Research Council
Funding Amount
$435,061.00
Summary
Low back pain is a major health problem worldwide. There is a lack of effective treatments and a “one size fits all” approach to treatment is being used. This innovative research program aims to change the way back pain is treated, by identifying specific types of back pain, determining the effectiveness of treatments for these types of back pain, and translating a targeted approach to management into clinical practice to improve the health of individuals with back pain.
Unravelling The Effects Of Physical Activity For Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$476,728.00
Summary
Physical activity is recommended internationally for the treatment of low back pain, but can prove beneficial or harmful. Ensuring it is prescribed safely and effectively is therefore of paramount importance. This research will advance the field by elucidating the relationship between back pain and physical activity. In collaboration with Medibank Private I will design and test e-health physical activity programs to reduce the burden of back pain for urban and rural communities.
An Integrated, Multi-system Approach To Understanding Persistent Pain
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Musculoskeletal pain is a major health problem in Australia, with an economic burden second only to cancer. Despite the scale of the problem, there are few effective treatments. This project examines a range of biological mechanisms that could explain why some people get better over time while others experiencing pain do not. The findings of this research will contribute to the development of new treatments that can be targeted to each individual to improve pain and disability.
Reconsideration Of The Mechanisms Underlying Movement Changes With Pain
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
Pain changes the way we move. Although undisputed, there is a surprising lack of agreement regarding the underlying mechanisms. This project involves an innovative mix of neurophysiological methods to investigate how the drive to muscle cells from the nervous system is altered during pain. We aim to resolve the perplexing problem of how pain changes our ability to activate muscle. Our findings are likely to provide a clear understanding of the underlying mechanisms and guide rehabilitation.
Whiplash Injury: Classification, Prediction And Directives For Improved Management Strategies.
Funder
National Health and Medical Research Council
Funding Amount
$331,674.00
Summary
Whiplash is a costly condition with many people developing chronic symptoms. This research aims to improve the diagnosis and classification of the condition from the time of injury until either recovery or the development of persistent pain. This will facilitate the early identification of those at risk of poor recovery and will lay the foundations for the development of improved early management, particularly in primary care.