The Centre for Research Excellence in Nursing Interventions for Hospitalised Patients will provide evidence to improve the nursing care of a broad range of hospitalised patients who are at risk of complications related to compromised skin integrity and poor pain/anxiety management. Systematic reviews and clinical trials will provide the basis for developing clinical practice guidelines to assist nurses in providing high quality care to the 3.5 million Australians admitted to hospital each year.
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hard ....Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hardware, software and communication systems to dynamically generate decision tools for safe and efficient power system operating conditions. These systems will also generate alarms if any risky operational situations arise.Read moreRead less
Safety in the Heavy Vehicle Industry: A Collaborative Response. The management and regulation of heavy vehicles, particularly in relation to safety, is recognised as an urgent issue at all levels of government across Australia. In the absence of research that identifies the key determinants of heavy vehicle crashes, countermeasures will continue to be based on anecdote. The proposed study will determine the role key risk factors, namely scheduling and sleep-related factors, play in heavy vehicl ....Safety in the Heavy Vehicle Industry: A Collaborative Response. The management and regulation of heavy vehicles, particularly in relation to safety, is recognised as an urgent issue at all levels of government across Australia. In the absence of research that identifies the key determinants of heavy vehicle crashes, countermeasures will continue to be based on anecdote. The proposed study will determine the role key risk factors, namely scheduling and sleep-related factors, play in heavy vehicle crashes and will identify cost-effective strategies to reduce the growing economic burden associated with these crashes.Read moreRead less
The roles of stress and immunocompetence in biological invasions. Invasive species pose a major threat to biodiversity worldwide; and within Australia, cane toads are widely viewed as one of the biggest such problems. Building on recent studies that reveal weakened immune systems in invasion-front toads, this project will provide a comprehensive understanding of immune responses in cane toads and native frogs, with the aim of exploiting the toads' immunocompromised state to develop new and more ....The roles of stress and immunocompetence in biological invasions. Invasive species pose a major threat to biodiversity worldwide; and within Australia, cane toads are widely viewed as one of the biggest such problems. Building on recent studies that reveal weakened immune systems in invasion-front toads, this project will provide a comprehensive understanding of immune responses in cane toads and native frogs, with the aim of exploiting the toads' immunocompromised state to develop new and more effective control measures. The project will develop a new paradigm about the roles of stress and immunity in biological invasion, applicable to the control of other invasive species and to understanding processes at work when environmental changes force species to shift their ranges.Read moreRead less
When every second counts: Multi-drone navigation in GPS-denied environments. The aim of this research is to develop a framework for multiple Unmanned Aerial Vehicles (UAV), that balances information sharing, exploration, localization, mapping, and other planning objectives thus allowing a team of UAVs to navigate in complex environments in time critical situations. This project expects to generate new knowledge in UAV navigation using an innovative approach by combining Simultaneous Localizatio ....When every second counts: Multi-drone navigation in GPS-denied environments. The aim of this research is to develop a framework for multiple Unmanned Aerial Vehicles (UAV), that balances information sharing, exploration, localization, mapping, and other planning objectives thus allowing a team of UAVs to navigate in complex environments in time critical situations. This project expects to generate new knowledge in UAV navigation using an innovative approach by combining Simultaneous Localization and Mapping (SLAM) algorithms with Partially Observable Markov Decision Processes (POMDP) and Deep Reinforcement learning. This should provide significant benefits, such as more responsive search and rescue inside collapsed buildings or underground mines, as well as fast target detection and mapping under the tree canopy. Read moreRead less
Understanding the origin, epidemiology and transmission threat of chlamydial infections between Australian native animals and livestock. Chlamydial infections of koalas and livestock cause diseases of significant economic and environmental concern. Molecular analysis of livestock and native animal strains will improve understanding of the factors associated with transmission of these important pathogens, improving the ability to manage affected Australian animal populations.
Acoustic loads on hypersonic engines. This project aims to understand how acoustic loads are generated in supersonic combustion ramjets (scramjets) to control sonic fatigue in reusable hypersonic vehicles. This knowledge could make space access affordable. This project will measure acoustic waves in scramjets. The anticipated discoveries will enable reusable, hypersonic vehicles to be used for space launch systems and high-speed aircraft. These systems will dramatically reduce the cost of space ....Acoustic loads on hypersonic engines. This project aims to understand how acoustic loads are generated in supersonic combustion ramjets (scramjets) to control sonic fatigue in reusable hypersonic vehicles. This knowledge could make space access affordable. This project will measure acoustic waves in scramjets. The anticipated discoveries will enable reusable, hypersonic vehicles to be used for space launch systems and high-speed aircraft. These systems will dramatically reduce the cost of space launch and global travel times. Expected benefits include reduced cost for access to space and the ability to design and develop advanced aerospace technology.Read moreRead less