Improving Pain And Movement Outcomes In Symptomatic Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
People fear getting painful knee osteoarthritis (OA) more than any other disease – it is seen as progressive and incurable. It often stops people from moving and staying healthy, resulting in an enormous burden on sufferers and the health care system. This program of research aims to understand what brain & nervous system processes might underlie these pain and movement problems and whether new brain-targeting treatment helps. This will allow us to better match treatment to what patients need.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Special Research Initiatives - Grant ID: SR180100005
Funder
Australian Research Council
Funding Amount
$1,225,000.00
Summary
Remediation of PFAS contaminated soil using soil washing and immobilisation. This project aims to assess the applicability of soil washing and immobilisation as cost-effective techniques for the remediation of per- and poly-fluroalkyl substance (PFAS) contaminated Australian soils. The project expects to establish the efficacy of the remediation of a range of PFASs, including many polyfluorinated precursors of perfluorinated, chemically-persistent legacy pollutants which are of concern. The proj ....Remediation of PFAS contaminated soil using soil washing and immobilisation. This project aims to assess the applicability of soil washing and immobilisation as cost-effective techniques for the remediation of per- and poly-fluroalkyl substance (PFAS) contaminated Australian soils. The project expects to establish the efficacy of the remediation of a range of PFASs, including many polyfluorinated precursors of perfluorinated, chemically-persistent legacy pollutants which are of concern. The project will provide a scientific basis for understanding the benefits and limitations associated with soil washing and immobilisation techniques and a more comprehensive understanding of future liabilities associated with formation of PFASs from precursors remaining in remediated soils. Collaboration with stakeholders will ensure benefits are captured both commercially and environmentally, as well as removing a potential and on-going health threat to communities exposed to these contaminants.Read moreRead less
Learning and choosing in a complex world. How do people make choices in a complex world? Making good choices requires expertise, but people must often forego rewards in order to acquire this knowledge. This is the essence of an "explore-exploit dilemma": to maximise rewards across a long time frame, people must take the time to explore and learn now. Empirically, this project aims to unify much of the existing psychological literature and extend it to cover richer, more complex problems. Theoret ....Learning and choosing in a complex world. How do people make choices in a complex world? Making good choices requires expertise, but people must often forego rewards in order to acquire this knowledge. This is the essence of an "explore-exploit dilemma": to maximise rewards across a long time frame, people must take the time to explore and learn now. Empirically, this project aims to unify much of the existing psychological literature and extend it to cover richer, more complex problems. Theoretically, the project aims to use tools from machine learning to compare human decision making to optimal planning models.Read moreRead less
Fertility Management of Koalas, Kangaroos and Wallabies. The aims of this work are to test a commercially available long-acting contraceptive on large populations of kangaroos and koalas, and to devise efficient, economic and practical ways of delivering these contraceptives to the animals. The outcome will be a system of controlling the number of these animals which is economically realistic and acceptable to national and international communities. The contraceptive is administered as a small, ....Fertility Management of Koalas, Kangaroos and Wallabies. The aims of this work are to test a commercially available long-acting contraceptive on large populations of kangaroos and koalas, and to devise efficient, economic and practical ways of delivering these contraceptives to the animals. The outcome will be a system of controlling the number of these animals which is economically realistic and acceptable to national and international communities. The contraceptive is administered as a small, subcutaneous implant in the back of the neck. It can be inserted very quickly and has no harmful side effects. A further outcome may be its adoption in other parts of the world, to the advantage of the company which manufactures it.Read moreRead less
The new voice of Multicultural Australian English. This project aims to generate an integrated and inclusive model of Australian-English, through phonetic analysis of the spoken language used by adolescents from a range of ethnic backgrounds. Australia is one of the most ethnically diverse countries in the world yet the complex relationship between speech production and cultural diversity is largely unknown in 21st century multicultural Australia. This project aims to establish how adolescents f ....The new voice of Multicultural Australian English. This project aims to generate an integrated and inclusive model of Australian-English, through phonetic analysis of the spoken language used by adolescents from a range of ethnic backgrounds. Australia is one of the most ethnically diverse countries in the world yet the complex relationship between speech production and cultural diversity is largely unknown in 21st century multicultural Australia. This project aims to establish how adolescents from different ethnicities use speech patterns to symbolically express their diverse sociocultural identities. The project expects to inform sociophonetic theories of variation, ethnicity, and identity, providing a framework for supporting sociocultural cohesion in Australia. Read moreRead less
The effect of sound change on children's speech in community diversity. This project aims to explain how children's speech processing adapts to cultural and linguistic diversity and how such adaptation may seed sound change in language. Using acoustic and articulatory (ultrasound) methods, the project intends to explain how children rapidly and authentically acquire the intricately nuanced accents of their communities. The project aims to advance theories of language variation and change by prov ....The effect of sound change on children's speech in community diversity. This project aims to explain how children's speech processing adapts to cultural and linguistic diversity and how such adaptation may seed sound change in language. Using acoustic and articulatory (ultrasound) methods, the project intends to explain how children rapidly and authentically acquire the intricately nuanced accents of their communities. The project aims to advance theories of language variation and change by providing new insights into the forces that shape the sounds of language. An understanding of how children's speech patterns develop and ultimately converge to local norms has implications for the social integration of second language learning children and refugee/asylum seekers, and for clinical and speech technology applications for children.Read moreRead less
Safe and accessible care for older survivors of psychological trauma. This project aims to improve the safety and accessibility of community aged care services for older survivors of psychological trauma, particularly those from diverse populations. We will co-design and test a practice framework that transforms the conceptual principles of trauma-informed care into actionable care behaviours and processes for implementation. Outcomes will include a world-first roadmap to guide implementation of ....Safe and accessible care for older survivors of psychological trauma. This project aims to improve the safety and accessibility of community aged care services for older survivors of psychological trauma, particularly those from diverse populations. We will co-design and test a practice framework that transforms the conceptual principles of trauma-informed care into actionable care behaviours and processes for implementation. Outcomes will include a world-first roadmap to guide implementation of trauma-informed aged care, as well for policy makers to regulate and monitor its delivery. The project will also increase knowledge about the priorities for change within aged care from the perspective of older trauma survivors, and improve understanding of how best to engage this group in co-design.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989067
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
The future of palaeoclimate and archaeological research in Australia: next generation instrumentation for chronology and environmental reconstruction. The outcomes of this project will promote a better understanding of Australia's arid continent and its surrounding marine environment, contribute to studies of global climate change, and provide new insights into the response of fragile ecosystems to such events and processes. The project addresses directly the National Research Priority 'Water - ....The future of palaeoclimate and archaeological research in Australia: next generation instrumentation for chronology and environmental reconstruction. The outcomes of this project will promote a better understanding of Australia's arid continent and its surrounding marine environment, contribute to studies of global climate change, and provide new insights into the response of fragile ecosystems to such events and processes. The project addresses directly the National Research Priority 'Water - a critical resource', 'Responding to climate change and variability', 'Overcoming soil loss, salinity and acidity', 'Sustainable use of Australia's biodiversity' and 'Understanding our region and the world'. It provides a consortium-type platform for highly productive collaborative research and training across eight universities and one research organisation in Australia.Read moreRead less