Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Spinal Cord Injury Pain: Understanding Mechanisms To Develop Treatments
Funder
National Health and Medical Research Council
Funding Amount
$597,675.00
Summary
Spinal cord injury has devastating effects on health and quality of life. Many of the major consequences of injury, such as chronic pain and loss of voluntary voiding, are "invisible" – i.e., they are not as visible as limitations of mobility. Our study aims to define the neurobiological changes that cause development of persistent pain after spinal cord injury and use pharmacological tools to attenuate the development of pain.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989491
Funder
Australian Research Council
Funding Amount
$172,025.00
Summary
Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemi ....Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemistry and hydrometallurgy, aquaculture, forensic analysis, Antarctic studies, and environmental monitoring. This will directly support our work falling under National Research Priorities 1 An Environmentally Sustainable Australia, 2 Promoting and Maintaining Good Health, 3 Frontier Technologies for Building and Transforming Australian Industries, and 4 Safeguarding Australia.Read moreRead less
Special Research Initiatives - Grant ID: SR180100005
Funder
Australian Research Council
Funding Amount
$1,225,000.00
Summary
Remediation of PFAS contaminated soil using soil washing and immobilisation. This project aims to assess the applicability of soil washing and immobilisation as cost-effective techniques for the remediation of per- and poly-fluroalkyl substance (PFAS) contaminated Australian soils. The project expects to establish the efficacy of the remediation of a range of PFASs, including many polyfluorinated precursors of perfluorinated, chemically-persistent legacy pollutants which are of concern. The proj ....Remediation of PFAS contaminated soil using soil washing and immobilisation. This project aims to assess the applicability of soil washing and immobilisation as cost-effective techniques for the remediation of per- and poly-fluroalkyl substance (PFAS) contaminated Australian soils. The project expects to establish the efficacy of the remediation of a range of PFASs, including many polyfluorinated precursors of perfluorinated, chemically-persistent legacy pollutants which are of concern. The project will provide a scientific basis for understanding the benefits and limitations associated with soil washing and immobilisation techniques and a more comprehensive understanding of future liabilities associated with formation of PFASs from precursors remaining in remediated soils. Collaboration with stakeholders will ensure benefits are captured both commercially and environmentally, as well as removing a potential and on-going health threat to communities exposed to these contaminants.Read moreRead less
Unified analysis of steel and composite frame structures subjected to static, thermal, earthquake and blast loading. Understanding the science of extreme loading on engineering structures is essential for their design, and increasingly with terrorism threats there is a need for assessment and strengthening of identified vulnerable critical infrastructure. Rational design paradigms have not yet matured for extreme load scenarios, and they are much-needed to protect life, limb and amenity. Austral ....Unified analysis of steel and composite frame structures subjected to static, thermal, earthquake and blast loading. Understanding the science of extreme loading on engineering structures is essential for their design, and increasingly with terrorism threats there is a need for assessment and strengthening of identified vulnerable critical infrastructure. Rational design paradigms have not yet matured for extreme load scenarios, and they are much-needed to protect life, limb and amenity. Australian research is at the forefront in steel and composite structures, and this project will strengthen Australia's positioning in the discipline by developing transparent design and assessment procedures from an efficient algorithm that delivers hands-on guidance for engineering practitioners.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100053
Funder
Australian Research Council
Funding Amount
$358,031.00
Summary
A national facility for the analysis of pyrogenic carbon. This project aims to develop a national facility for pyrogenic carbon analysis. Pyrogenic carbon is a poorly constrained, slow-cycling terrestrial carbon pool with significant carbon sequestration potential. The project expects to expand the newly developed hydrogen pyrolysis analytical capability to provide high throughput, robust measurement of the abundance and isotope composition of pyrogenic carbon in soils and sediments. This will p ....A national facility for the analysis of pyrogenic carbon. This project aims to develop a national facility for pyrogenic carbon analysis. Pyrogenic carbon is a poorly constrained, slow-cycling terrestrial carbon pool with significant carbon sequestration potential. The project expects to expand the newly developed hydrogen pyrolysis analytical capability to provide high throughput, robust measurement of the abundance and isotope composition of pyrogenic carbon in soils and sediments. This will provide significant benefit, such as the ability to make significant advances in areas as diverse as geochronology, archaeology, palaeoecology, soil science geomorphology and carbon cycle/sequestration science.Read moreRead less
Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and aga ....Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and again make Australian TID the international benchmark. Results will highlight the role of TID practices in improving recreational participation and maximising, attracting, developing and retaining sport talent. This will result in improved use of sports limited TID funding by providing greater understanding of factors that influence elite selection and sport development.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560732
Funder
Australian Research Council
Funding Amount
$114,036.00
Summary
Australian Policy Online Enhancement Project. Australian Policy Online is Australia's only comprehensive gateway providing access to research reports available electronically from nearly 120 Australian research centres and other organisations. This project will broaden the range of material available, providing important new resources to users of the site, reinforcing the site's role in the national information infrastructure through its involvement in a number of innovative projects, and streng ....Australian Policy Online Enhancement Project. Australian Policy Online is Australia's only comprehensive gateway providing access to research reports available electronically from nearly 120 Australian research centres and other organisations. This project will broaden the range of material available, providing important new resources to users of the site, reinforcing the site's role in the national information infrastructure through its involvement in a number of innovative projects, and strengthening APO's international dimension. APO will be a series of datasets comparing Australia's policy performance with other OECD countries, an annotated bibliography of hard-copy material and a series of opinion surveys; these resources are not available from other online sources.Read moreRead less