A new generation of photoresists for three- dimensional laser lithography. This project aims at a step-change in photoresist technology by introducing visible-light-induced photochemistry as the basis of next generation direct laser writing (DLW) technology. This willenable functional photoresists that allow precision coding of complex soft matter material properties on the three-dimensional nanoscale. The outcomes of the project will enable the mild fabrication of three-dimensional structures w ....A new generation of photoresists for three- dimensional laser lithography. This project aims at a step-change in photoresist technology by introducing visible-light-induced photochemistry as the basis of next generation direct laser writing (DLW) technology. This willenable functional photoresists that allow precision coding of complex soft matter material properties on the three-dimensional nanoscale. The outcomes of the project will enable the mild fabrication of three-dimensional structures with unique property control and resolution, benefitting diverse fields ranging from designer (stem) cell niches and lab-on-a-chip applications to photonic wire bonding.Read moreRead less
Flow process and visible-light driven reactions for polymer manufacturing. This project aims to develop rapid, scalable light-driven continuous flow processing techniques that allow the production of value-added synthetic polymers that cannot be achieved by existing technologies. The project will take advantage of the spatio-temporal control of the light mediated polymerisation with flow process to achieve control over the primary structure, the sequential arrangement of monomer units in a polym ....Flow process and visible-light driven reactions for polymer manufacturing. This project aims to develop rapid, scalable light-driven continuous flow processing techniques that allow the production of value-added synthetic polymers that cannot be achieved by existing technologies. The project will take advantage of the spatio-temporal control of the light mediated polymerisation with flow process to achieve control over the primary structure, the sequential arrangement of monomer units in a polymer chain and the molecular weight distribution. The project will result in the preparation of functional polymers containing a specific arrangement of monomers in the polymer chain and a precise distribution of polymer chains. The development of such process will result in the development of advanced materials.Read moreRead less
Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailor ....Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailored towards bioactive and biocompatible material to create a drug delivery platform for more efficient disease treatment. The outcome will be better understanding on how polymer platelets can be obtained and how they compare in their biological activity with spherical nanoparticles.Read moreRead less
Precision-built dynamic and functional polymer vesicles. The project aims to create new precision-built polymer vesicles with controlled size, stability, functionality and environmental responsiveness to mimic some of the key dynamic functions of the cell. The project expects to generate new knowledge on the dynamic interplay between the polymer and its bilayer including on-demand activated polymerisations and reactions, logic gates and in situ sensors. Expected outcomes of this project include ....Precision-built dynamic and functional polymer vesicles. The project aims to create new precision-built polymer vesicles with controlled size, stability, functionality and environmental responsiveness to mimic some of the key dynamic functions of the cell. The project expects to generate new knowledge on the dynamic interplay between the polymer and its bilayer including on-demand activated polymerisations and reactions, logic gates and in situ sensors. Expected outcomes of this project include new synthetic polymer techniques and new quantitative insights into the role of compartmentalisation on chemical reactions and polymerisations. This project will provide fundamental knowledge on bio/polymer vesicles with great potential to advance the polymer industry in Australia.Read moreRead less
Virus-inspired nanoparticles based on polyion complex micelles. Viruses are nature's nanoparticles that have evolved over millions of years into intelligent nanoparticles. The unique structure of viruses with their patchy surface has inspired the design of a new drug carrier by employing the power of polymers to self-organize. The project aims at mimicking nature’s nanoparticles with intelligent polymers while enabling the design of a platform that can entrap therapeutic proteins and enhance the ....Virus-inspired nanoparticles based on polyion complex micelles. Viruses are nature's nanoparticles that have evolved over millions of years into intelligent nanoparticles. The unique structure of viruses with their patchy surface has inspired the design of a new drug carrier by employing the power of polymers to self-organize. The project aims at mimicking nature’s nanoparticles with intelligent polymers while enabling the design of a platform that can entrap therapeutic proteins and enhance their delivery. The focus will be to gain in-depth understanding on the polymer self-assembly process in order to design a synthetically robust system that can be applied to various payloads. As a result, novel nanoparticles with virus-inspired structures for the delivery of therapeutic proteins will be created.Read moreRead less
Chiral synthetic macromolecules - control of sequence and stereochemistry. This project aims to assemble a library of novel chiral polymers mimicking natural peptides with precisely controlled primary structures using emerging synthetic technologies. A systematic investigation of these synthetic materials will provide an in-depth understanding of how sequence and stereochemistry influence chemical and physical properties. Employing rational design principles, desired functionality could be optim ....Chiral synthetic macromolecules - control of sequence and stereochemistry. This project aims to assemble a library of novel chiral polymers mimicking natural peptides with precisely controlled primary structures using emerging synthetic technologies. A systematic investigation of these synthetic materials will provide an in-depth understanding of how sequence and stereochemistry influence chemical and physical properties. Employing rational design principles, desired functionality could be optimised through the selective modification of polymer structure. These materials should be able to emulate the unique properties and functionality of natural peptides/proteins, making them invaluable for biochemical applications, such as molecular recognition and asymmetric catalysis.Read moreRead less
Manufacturing Nanostructured Polymer Thin Films using Visible Light. This research aims the development of selective photochemical tools driven by different colours of light for the fabrication of nanostructured polymer brush thin films. By using different wavelengths to selectively activate specific chemical reactions, this will enable multiple reactions to be performed simultaneously, significantly streamlining fabrication. Additionally, the increased selectivity offers pathways to more sophis ....Manufacturing Nanostructured Polymer Thin Films using Visible Light. This research aims the development of selective photochemical tools driven by different colours of light for the fabrication of nanostructured polymer brush thin films. By using different wavelengths to selectively activate specific chemical reactions, this will enable multiple reactions to be performed simultaneously, significantly streamlining fabrication. Additionally, the increased selectivity offers pathways to more sophisticated nanoarchitectures in comparison to existing methods. This research will lead to the fabrication of 3D polymer brush architectures with unparalleled precision, which will be of high scientific and industrial value for a diverse range of applications, such as optoelectronics, nanoactuation, and sensing.Read moreRead less
Biomimetic hydrogels. Hydrogels are promising materials to repair and regenerate damaged tissues, but their weak mechanical properties limit their applications. This project aims to develop hydrogels with better mechanical properties by mimicking the way natural tissues, such as cartilage, work. Specifically, we aim to develop a new class of hydrogels by adding molecular polymer brushes to traditional materials. We will design the hydrogels with long-term stability and render them suitable as vi ....Biomimetic hydrogels. Hydrogels are promising materials to repair and regenerate damaged tissues, but their weak mechanical properties limit their applications. This project aims to develop hydrogels with better mechanical properties by mimicking the way natural tissues, such as cartilage, work. Specifically, we aim to develop a new class of hydrogels by adding molecular polymer brushes to traditional materials. We will design the hydrogels with long-term stability and render them suitable as viable hosts for chondrocytes. Through this project, we will grow fundamental knowledge in polymer chemistry and tissue engineering, and pave the way for new technologies to repair damaged joints and tissues.Read moreRead less